“…For mammalian and especially for human species, the toxicity of xenobiotics is experimentally determined on laboratory animals (rat, mouse, etc.) and sometimes, mathematically extrapolated from the QSAR (Stark et al, 1986;Enslein et al, 1987;Nirmalakhandan and Speece, 1988;Devillers et al, 1985;Devillers and Chambon, 1989;Nendza et al, 1990;Phillips et al, 1990;Munkittrick and Power, 1991;Okkerman et al, 1991;Kaiser and Esterby, 1991;Fort, 1992;Shrivastava et al, 1992;Kaiser et al, 1994). Moreover, for environmental pollutants (such as those tested in this study), the most used assays are the lethality assay performed on fish (Brachydanio rerio, Pimephales promelas, etc.)…”