Comparison of immunotoxicity among tetrachloro-, pentachloro-, tetrabromo- and pentabromo-dibenzo-p-dioxins in mice

Ao, Kana; Suzuki, Takehiro; Murai, Hikari; Matsumoto, Michi; Nagai, Haruko; Miyamoto, Yuri; Tohyama, Chiharu; Nohara, Keiko

doi:10.1016/j.tox.2008.10.024

Cited by 17 publications

(14 citation statements)

References 27 publications

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“…Toxicity studies have been reported for different brominated congeners using oral, ip, and sc administration (Ao et al, 2009;Haijima et al, 2010;Ivens et al, 1992Ivens et al, ,1993Mason et al, 1987a;Moore et al, 1979;Nagao et al, 1990;White et al, 2012). These studies indicate that the toxic effects in rodents for 2,3,7,8-TeBDD are in the same dose range as that of 2,3,7,8-TeCDD, indicating a comparable potency for both congeners.…”

Section: Toxicity In Mammalian Modelsmentioning

confidence: 99%

Polybrominated Dibenzo-p-Dioxins, Dibenzofurans, and Biphenyls: Inclusion in the Toxicity Equivalency Factor Concept for Dioxin-Like Compounds

Berg

Denison

Birnbaum

et al. 2013

Toxicological Sciences

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201

128

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In 2011, a joint World Health Organization (WHO) and United Nations Environment Programme (UNEP) expert consultation took place, during which the possible inclusion of brominated analogues of the dioxin-like compounds in the WHO Toxicity Equivalency Factor (TEF) scheme was evaluated. The expert panel concluded that polybrominated dibenzo-p-dioxins (PBDDs), dibenzofurans (PBDFs), and some dioxin-like biphenyls (dl-PBBs) may contribute significantly in daily human background exposure to the total dioxin toxic equivalencies (TEQs). These compounds are also commonly found in the aquatic environment. Available data for fish toxicity were evaluated for possible inclusion in the WHO-UNEP TEF scheme (van den Berg et al., 1998). Because of the limited database, it was decided not to derive specific WHO-UNEP TEFs for fish, but for ecotoxicological risk assessment, the use of specific relative effect potencies (REPs) from fish embryo assays is recommended. Based on the limited mammalian REP database for these brominated compounds, it was concluded that sufficient differentiation from the present TEF values of the chlorinated analogues (van den Berg et al., 2006) was not possible. However, the REPs for PBDDs, PBDFs, and non-ortho dl-PBBs in mammals closely follow those of the chlorinated analogues, at least within one order of magnitude. Therefore, the use of similar interim TEF values for brominated and chlorinated congeners for human risk assessment is recommended, pending more detailed information in the future.

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Section: Toxicity In Mammalian Modelsmentioning

confidence: 99%

Polybrominated Dibenzo-p-Dioxins, Dibenzofurans, and Biphenyls: Inclusion in the Toxicity Equivalency Factor Concept for Dioxin-Like Compounds

Berg

Denison

Birnbaum

et al. 2013

Toxicological Sciences

Self Cite

201

128

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“…Transcriptional responses of sex hormone-related genes in the brain were also observed following DP exposure, suggesting possible sex hormone disrupting potentials of DP. In female C57BL/6J mice, 2,3,7,8-TeCDD and 2,3,7,8-TeBDD showed nearly identical potencies for endpoints that detect immunotoxicity, such as thymus weight and thymocyte numbers and spleen weight and splenocyte numbers (Ao et al, 2009). Additionally, PeBDD caused dose-independent inhibition of IL-5 production by splenocytes (Ao et al, 2009).…”

Section: Disrupting Hormonesmentioning

confidence: 93%

“…In female C57BL/6J mice, 2,3,7,8-TeCDD and 2,3,7,8-TeBDD showed nearly identical potencies for endpoints that detect immunotoxicity, such as thymus weight and thymocyte numbers and spleen weight and splenocyte numbers (Ao et al, 2009). Additionally, PeBDD caused dose-independent inhibition of IL-5 production by splenocytes (Ao et al, 2009). Another recent study presented relative potencies for immune suppression of several PBDD/Fs and their chlorinated analogs in female B6C3F1/N mice.…”

Section: Disrupting Hormonesmentioning

confidence: 94%

Levels of Non-PBDE Halogenated Fire Retardants and Brominated Dioxins and their Toxicological Effects in Indoor Environments - A Review

Hsu

Arcega

Gou

et al. 2018

Aerosol Air Qual. Res.

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Non-polybrominated diphenyl ether (non-PBDE) halogenated fire retardants (HFRs) such as new or novel brominated fire retardants (NBFRs) and dechlorane plus (DP) have been widely spread in the environment and recognized as emerging persistent organic pollutants (POPs) in the recent years, mainly due to the continuous increase in their global demand, especially after the worldwide restrictions on PBDE use. Polybrominated dibenzo-p-dioxins/furans (PBDD/Fs) are the unintentional byproducts of PBDE commercial formulations in the indoor environment. Although HFRs, including NBFRs, DP, and PBDD/Fs, are ubiquitous in the indoor environment due to the large-volume release from the surfaces of consumer products, only a few in vitro and in vivo studies have addressed their toxic effects. In this review article, global data on NBFRs, including decabromodiphenyl ethane (DBDPE), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), bis(2-ethylhexyl)-3,4,5,6-tetrabromophthalate (BEH-TEBP), and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB), DP, including syn-DP and anti-DP, and PBDD/Fs in indoor aerosol and dust are summarized from recent literature. Based on the gathered data, indoor dust is a major sink for indoor contamination and is of great concern due to the fact that dust ingestion is one of the primary routes for human exposure to these chemicals. Lastly, the toxic effects of NBFRs, DP, and PBDD/Fs identified in in vitro and in vivo studies are summarized and discussed based on the current published reports. However, there is still a lack of sufficient toxicity data for assessing their risks. Future works are encouraged to focus on indoor PM 2.5 -bound HFR levels to further evaluate their toxic effects on human health.

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“…In a recent study on mammalian laboratory model, it was found that TCDD exposure of mice immunized with ovalbumin (OVA) decreased the splenocyte numbers and also decreased the production of cytokines by splenocytes at lower doses of TCDD. 47 The viability of extruded coelomocytes seems to be not affected by the PCDD/Fs concentrations ( Figure 5). This indicated that the adverse effects noted were not the result of decreased cell viability.…”

Section: Articlementioning

confidence: 96%

Effects of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans on phagocytic response of Eisenia andrei coelomocytes

et al. 2011

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The immunotoxicological effects of polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDDs/Fs) mixtures on Eisenia andrei earthworms have never been studied. In this work we investigated these effects both for in vitro and in vivo exposure, using the viability and the phagocytic activity of coelomocytes as immunological biomarkers and the flow cytometry was used for analysis. The in vitro exposure revealed a cytotoxic effect of PCDD/Fs mixture (C2) containing 50¥10 -3 ng/mL of 2, 3, 7, 8-TCDD and an induction of the phagocytic capacity at the mixture (C1) containing 25¥10 -3 ng/mL of 2, 3, 7, 8-TCDD. In the in vivo filter paper exposure, the immunocompetence of earthworms was assessed after 3 h-exposure to mixtures of PCDD/Fs at the levels of C1, C2, C3 and C4 containing about; 0.05, 0.3, 0.5 and 0.83 ng of 2, 3, 7, 8-TCDD/cm², respectively. Morphological observations showed an excessive secretion of mucus and body surface lesions in worms exposed to higher concentrations (C3 and C4), which revealed that these organisms were affected by PCDD/Fs either through skin and/or by feeding. The levels of the extruded cell yield decreased significantly at all the concentrations tested. However, the cell viability was shown to be unaffected by PCDD/Fs concentrations. It was also shown, that exposure to the highest PCDD/Fs concentrations; C2, C3 and C4 inhibited both phagocytic activity and efficiency.

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Comparison of immunotoxicity among tetrachloro-, pentachloro-, tetrabromo- and pentabromo-dibenzo-p-dioxins in mice

Cited by 17 publications

References 27 publications

Polybrominated Dibenzo-p-Dioxins, Dibenzofurans, and Biphenyls: Inclusion in the Toxicity Equivalency Factor Concept for Dioxin-Like Compounds

Polybrominated Dibenzo-p-Dioxins, Dibenzofurans, and Biphenyls: Inclusion in the Toxicity Equivalency Factor Concept for Dioxin-Like Compounds

Levels of Non-PBDE Halogenated Fire Retardants and Brominated Dioxins and their Toxicological Effects in Indoor Environments - A Review

Effects of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans on phagocytic response of Eisenia andrei coelomocytes

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