Comparison of immunomodulatory effects of three polysaccharide fractions from Lentinula edodes water extracts

Chen, Shuping; Liu, Cencen; Huang, Xiao‐Jun; Hu, Liuyun; Huang, Yifei; Chen, Hongzhang; Fang, Qiuyue; Dong, Nan; Li, Mingzhi; Tang, Wei; Nie, Shaoping

doi:10.1016/j.jff.2020.103791

Cited by 45 publications

(33 citation statements)

References 35 publications

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“…LEPs are also known for their immunomodulatory effects. The three fractions of LEP (F1, F2, and F3) demonstrated immunomodulatory effects through enhancing cellular immunity by increasing the thymus index, DTH, and proliferation of T splenocytes [93]. RPS and ERPS of L. edodes also exhibit antioxidative, anti-inflammatory, and organ protective effects against the LPS-induced sepsis in mice, which makes them suitable for functional foods and treatment of sepsis and its complications [91].…”

Section: Mushroom Species Containing Bioactive Polysaccharidesmentioning

confidence: 99%

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Niego

Rapior

Thongklang

et al. 2021

JoF

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Macrofungi production and economic value have been increasing globally. The demand for macrofungi has expanded rapidly owing to their popularity among consumers, pleasant taste, and unique flavors. The presence of high quality proteins, polysaccharides, unsaturated fatty acids, minerals, triterpene sterols, and secondary metabolites makes macrofungi an important commodity. Macrofungi are well known for their ability to protect from or cure various health problems, such as immunodeficiency, cancer, inflammation, hypertension, hyperlipidemia, hypercholesterolemia, and obesity. Many studies have demonstrated their medicinal properties, supported by both in vivo and in vitro experimental studies, as well as clinical trials. Numerous bioactive compounds isolated from mushrooms, such as polysaccharides, proteins, fats, phenolic compounds, and vitamins, possess strong bioactivities. Consequently, they can be considered as an important source of nutraceuticals. Numerous edible mushrooms have been studied for their bioactivities, but only a few species have made it to the market. Many species remain to be explored. The converging trends and popularity of eastern herbal medicines, natural/organic food product preference, gut-healthy products, and positive outlook towards sports nutrition are supporting the growth in the medicinal mushroom market. The consumption of medicinal mushrooms as functional food or dietary supplement is expected to markedly increase in the future. The global medicinal mushroom market size is projected to increase by USD 13.88 billion from 2018 to 2022. The global market values of promising bioactive compounds, such as lentinan and lovastatin, are also expected to rise. With such a market growth, mushroom nutraceuticals hold to be very promising in the years to come.

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Section: Mushroom Species Containing Bioactive Polysaccharidesmentioning

confidence: 99%

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Niego

Rapior

Thongklang

et al. 2021

JoF

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“…The thymus and spleen are important immune organs, responsible for lymphocyte production [ 51 ]. When the body is attacked by foreign objects, an immune reaction occurs, in which a large number of B lymphocytes and T lymphocytes are produced.…”

Section: Resultsmentioning

confidence: 99%

“…Among these, IgG is the most common, and most antibody reactions involve IgG-mediated effector functions. The presence of specific IgG and its subclasses in serum reflects the body’s immune level and the expression level of different subclasses of IgG determine the type of immune response [ 51 ]. The production of OVA-specific IgG and specific IgG subclass in mouse serum was determined using ELISA.…”

Section: Discussionmentioning

confidence: 99%

Eucommia ulmoides Leaf Polysaccharide in Conjugation with Ovalbumin Act as Delivery System Can Improve Immune Response

et al. 2021

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In this investigation, to maximize the desired immunoenhancement effects of PsEUL and stimulate an efficient humoral and cellular immune response against an antigen, PsEUL and the model antigen ovalbumin (OVA) were coupled using the N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC) reaction to yield a novel delivery system (PsEUL-OVA). The physicochemical characteristics and immune regulation effects of this new system were investigated. We found the yield of this EDC method to be 46.25%. In vitro, PsEUL-OVA (200 μg mL−1) could enhance macrophage proliferation and increase their phagocytic efficiency. In vivo, PsEUL-OVA could significantly increase the levels of OVA-specific antibody (IgG, IgG1, IgG2a, and IgG2b) titers and cytokine (IL-2, IL-4, IL-6, IFN-γ) levels. Additionally, it could activate T lymphocytes and facilitate the maturation of dendritic cells (DCs). These findings collectively suggested that PsEUL-OVA induced humoral and cellular immune responses by promoting the phagocytic activity of macrophages and DCs. Taken together, these results revealed that PsEUL-OVA had the potential to improve immune responses and provide a promising theoretical basis for the design of a novel delivery system.

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“…Hot water extraction is a common method to extract MOPs ( Chen et al, 2020 , Zhu et al, 2017 ). Polysaccharides from M. oleifera Lam leaves were prepared in hot water at an extraction temperature of 90 °C, extraction time of 4 h, and solid-iquid ratio of 1:20 (W/W), and the final MOPs yield was 6.84% ( Wang et al, 2018 ).…”

Section: Extraction Separation and Purification Methods Of Mopsmentioning

confidence: 99%

Recent developments in Moringa oleifera Lam. polysaccharides: A review of the relationship between extraction methods, structural characteristics and functional activities

et al. 2022

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Comparison of immunomodulatory effects of three polysaccharide fractions from Lentinula edodes water extracts

Cited by 45 publications

References 35 publications

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Eucommia ulmoides Leaf Polysaccharide in Conjugation with Ovalbumin Act as Delivery System Can Improve Immune Response

Recent developments in Moringa oleifera Lam. polysaccharides: A review of the relationship between extraction methods, structural characteristics and functional activities

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