Comparison of Iceball Diameter and Temperature Distribution Achieved with 3-mm Accuprobe Cryoprobes in Porcine and Human Liver Tissue and Human Colorectal Liver Metastases in Vitro
“…Probes of 3, 5 and 8 mm in diameter are simulated for a single freeze cycle of 20 min on a 15 mm diameter tumor. The probe tip temperature follows a uniform reduction in temperature to below À175 1C within the first 3 min independent of the tissue being frozen (Popken et al, 2000).…”
“…Probes of 3, 5 and 8 mm in diameter are simulated for a single freeze cycle of 20 min on a 15 mm diameter tumor. The probe tip temperature follows a uniform reduction in temperature to below À175 1C within the first 3 min independent of the tissue being frozen (Popken et al, 2000).…”
“…A high risk of recurrence was reported above this size [2-4, 22, 23] . Multiple applications used to treat large tumors enhance the risk of tumor dissemination and other complications such as cryoshock observed with cryotherapy [23][24][25] . d Photo obtained on gross examination of the lesion sectioned along the probe track.…”
Background: The shape of the induced thermal ablation area is as important as its dimension. The aim of this study was to analyze the size reproducibility and the aspect of the interstitial ultrasonic ablation obtained by a planar transducer in porcine liver in vivo. Methods: Five pigs were used. Two complete ultrasonic lesions were made in each animal under pedicle clamping. All the lesions underwent MR examination on day 7 and then a histological analysis. Results: The tested probe has the advantage of providing a step-by-step and highly directional treatment in the target zone. The ultrasonic lesions presented as well-defined and homogenous areas of tissue coagulation. The lesion volumes ranged from 8.1 to 92.3 cm3 with an averaged lesion length of 56 mm at gross examination. Three-dimensional reconstruction of the lesions from the MR images showed cylindrical and conical shapes. Large intrahepatic vessels distorted the lesion shape, and the vicinity of the application to the liver surface increased significantly the volume of the ultrasonic necrosis. Histological examination showed complete necrosis in the area of damage. Conclusion: The ultrasonic ablation has a regular shape, always with sharply defined borders. However, it showed some variability in the size of the induced lesions.
“…The developed model has been validated by comparing its temperature predictions with in vitro experimental data obtained from 2000) conducted experiments of a single freeze-cycle for 20 min on a human colorectal cancer liver metastases held at a saline bath at 37°C [26]. A 3 mm Accuprobe held at a relatively constant temperature of -180°C is used for cryo-freezing with thermocouples positioned at 10, 14 and 18 mm away from cryoprobe [26].…”
Section: Comparing Model With Experimentsmentioning
confidence: 99%
“…A 3 mm Accuprobe held at a relatively constant temperature of -180°C is used for cryo-freezing with thermocouples positioned at 10, 14 and 18 mm away from cryoprobe [26]. The reader is referred to their work for greater details regarding the experimental procedure and method.…”
Section: Comparing Model With Experimentsmentioning
confidence: 99%
“…(a) Comparison of temperature profiles from simulation and data obtained from experimental setup employing bio-gel with 95% confidence intervals; and (b) comparison of temperature profiles from simulation and data obtained from the literature(Popken et al, 2000).…”
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