Comparison of ibuprofen and indomethacin therapy for patent ductus arteriosus in preterm infants

Abstract

Ibuprofen therapy is as efficacious as indomethacin for the treatment of PDA in preterm infants. Infants treated with ibuprofen have higher creatinine clearance and urine output and lower serum creatinine and BUN values than infants treated with indomethacin.

Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis?

“…Search results and citation lists for prior publications identified 75 randomized-controlled trials of interventions that close a PDA in preterm infants. In 26 trials (five comparing long and short courses of indomethacin, [37][38][39][40][41] 19 comparing indomethacin and ibuprofen, [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60] and two that included very early crossover to treatment of nonresponders 29,61 ), rates of ductal closure did not differ between treatment assignments, precluding evaluation of effects of ductal closure on other outcomes, so these were excluded. The remaining 49 trials, 36, including 4728 subjects, were deemed potentially informative, as all but one documented substantial reduction in ductal patency after treatment.…”

Ibuprofen Versus Continuous Indomethacin in Premature Neonates With Patent Ductus Arteriosus: Is the Difference in the Mode of Administration?

“…Because it purportedly lacks these side effects, ibuprofen has been proposed as a pharmacologically similar, but therapeutically preferential alternative in the treatment of PDA (5)(6)(7)(8)(9)(10)(11). Ibuprofen is also a cyclooxygenase inhibitor, which seems to be equally effective in mediating ductal closure, while minimizing adverse renal effects (11).…”

Determination of Ibuprpfen in Aqueaus Solutions and Pharmacetical Preparations by UV-VIS Spectrophotometric

“…Fixed all the conditions and shaking the mixture with of different (2,3,4,5,6,7) min to to choice the sutabil shaking time for the complex extraction and measure the absorbance after each shaking, use UV-VIS spectroscopy. …”

“…To improve the solubility, several approaches such as solid dispersion, [4] prodrug and inclusion complex, It was derived from propionic acid by the research arm of boots group during 1960 s. [5] It is chemically (RS)-2-(4-(2-METHYL PROPYL) PHENYL ISOPROPIONIC ACID (Fig.(1)). [6,7] It is known that most of (NSAIDs) inhibit the enzyme COX (Cyclooxygenase enzyme) and production of prostaglandins. traditional NSAIDs, differ in their relative inhibitory potency against to iso-forms of COX:COX-1 and COX-2.…”