Comparison of I.V. Diazepam and Hydroxyzine as Surgical Premedicants

Wender, Ronald H.; Conner, J. T.; Bellville, J. Weldon; Schehl, D.; Dorey, Fred; Katz, Ronald L.

doi:10.1093/bja/49.9.907

Cited by 15 publications

(5 citation statements)

References 6 publications

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“…I -5 Previous studies have shown that patients anaesthetised with a tranquilliser are less anxious and less easily upset in the postoperative period. 6 Because of midazolam's short action its induction properties were compared with those of thiopentone. Successful induction of anaesthesia was achieved in both groups of patients.…”

Section: Discussionmentioning

confidence: 99%

Midazolam for the Intravenous Induction of Anaesthesia in Children

1982

Anaesth Intensive Care

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Midazolam was compared with thiopentone as an intravenous anaesthetic induction agent in children between four and twelve years of age undergoing elective minor surgical procedures. Successful induction of anaesthesia was achieved in both groups of patients. With midazolam induction time was longer than with thiopentone, but the difference was not statistically significant. The incidence of apnoea was greater with thiopentone, but not significantly so. lt is concluded that midazolam is effective and safe, and could prove a reasonable alternative to thiopentone as an intravenous induction agent in children undergoing elective minor operations.

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Section: Discussionmentioning

confidence: 99%

Midazolam for the Intravenous Induction of Anaesthesia in Children

1982

Anaesth Intensive Care

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“…Clinical manifestations of diazepam depend on its concentration in the blood and are particularly marked after intravenous administration, being manifested in man mainly by somnolence, unclear vision, amnesia and incoordination (Hillestad et al 1974). With increasing diazepam doses its sedative effect rises more rapidly than the anxiolytic one (Wender et al 1977). To tranquilize fallow-deer before treatment, diazepam-medicated feed was fed at a rate as high as 38 mg diazepam/kg body mass (Done et al 1975).…”

Section: Discussionmentioning

confidence: 99%

Growth, Metabolic and Adrenocortical Effects of Single and Repeated Administration of Diazepam in Piglets

Dvorák¹

1980

Acta Vet. Brno

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Dvorak M.: Growth, Metabolic and Adrenocortical Effects of Single and Repeated Administration of Diazepam in Piglets. Acta vet. Brno, 49, 1980: 177 -186. Diazepam was injected as a single i/m dose to suckling piglets of two groups on the 2nd day after birth at 0.5 or 1.0 mgjkg body mass. In two other groups of pigs weaned at 4 weeks of age it was injected at 0.5 mgjkg body mass or fed for 14 days in feed medicated at 8 mg/kg after weaning. The tranquilizing effect was substantially more intense in newborn than in weaned piglets. A rise in relative liver mass was found only in newborn animals 2 hours after diazepam administration. The adrenocortical function of the experimental animals proved unaffected, but their plasma Ll-hydroxycorticcsteroid level showed a downward trend, compared to controls. Total plasma protein, glucose, urea, free fatty acid and cholesterol concentrations were not affected. The growth performance of piglets injected on the 2nd days after birth was:not impaired: their growth expressed in terms of total gain in body mass from birth to weaning was 6.8 per cent higher than that of their untreated littermates. Similarly, piglets fed diazepam-medicated feed at an average of 0.35 mg/kg body mass for 14 days after weaning gained 21 per cent more than the controls. Their feed consumption was practically the same as in the controls, but their feed conversion efficiency was better. Not all diazepam-medicated piglets showed signs of tranquilization. The alleviation of stress as suggested by blockade of the circulating corticosteroid increase during handling of the animals and the other results indicate the usefulness of diazepam as tranquilizer in pigs. , stress, neonatal influences, development, pig. Tranquilization

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“…Hydroksyzyna według danych rejestracyjnych produktu w premedykacji przed zabiegiem operacyjnym powinna być stosowana w dawce 50 mg w dwóch podaniach lub 100 mg w pojedynczej dawce doustnie. Istnieją doniesienia, iż substancja ta ma mniejsze działanie anksjolityczne aniżeli benzodiazepiny, przy stosunkowo łagodnych skutkach niepożądanych [12][13][14]. Należy pamiętać o działaniu przeciwświądowym leku, który może zmniejszać natężenie tego objawu u pacjentów onkologicznych [15].…”

Section: Zmniejszenia Lęku Przed Procedurą Zabiegową U Pacjentów Paliatywnychunclassified

Application of anesthetic premedication in palliative medicine

Prusator-Żędzian¹,

Jasiewicz²,

Kościuczuk³

et al. 2021

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as well as gabapentinoids and painkillers, are recommended drugs. A wide range of other medications is used for the premedication of patients in palliative medicine. Giving up premedication before painful procedures and surgery in the group of palliative medicine patients is not recommended. The benefits of premedication in the form of anxiolytic and analgesic effects outweigh the potential side effects of premedication drugs.

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Comparison of I.V. Diazepam and Hydroxyzine as Surgical Premedicants

Cited by 15 publications

References 6 publications

Midazolam for the Intravenous Induction of Anaesthesia in Children

Midazolam for the Intravenous Induction of Anaesthesia in Children

Growth, Metabolic and Adrenocortical Effects of Single and Repeated Administration of Diazepam in Piglets

Application of anesthetic premedication in palliative medicine

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