Comparison of <i>in vivo</i> dental pulp responses to capping with <scp>iR</scp>oot <scp>BP</scp> Plus and mineral trioxide aggregate

Shi, Shuang; Bao, Zhi-Fan; Liu, Y.; Zhang, D. D.; Chen, Xu; Jiang, Li; Ma, Zhiyuan

doi:10.1111/iej.12439

Cited by 55 publications

(51 citation statements)

References 26 publications

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“…, Shi et al . ). These materials as well as Portland cement and TheraCal LC have also shown similar to significantly better outcomes compared to calcium hydroxide in terms of pulp inflammation and dentine tissue formation (Asgary et al .…”

Section: Vital Pulp Therapiesmentioning

confidence: 97%

Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part I: vital pulp therapy

2017

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Mineral trioxide aggregate (MTA) is a bioactive endodontic cement (BEC) mainly comprised of calcium and silicate elements. The cement was introduced by Torabinejad in the 1990s and has been approved by the Food and Drug Administration to be used in the United States in 1997. A number of new BECs have also been introduced to the market, including BioAggregate, Biodentine, BioRoot RCS, calcium-enriched mixture cement, Endo-CPM, Endocem, EndoSequence, EndoBinder, EndoSeal MTA, iRoot, MicroMega MTA, MTA Bio, MTA Fillapex, MTA Plus, NeoMTA Plus, OrthoMTA, Quick-Set, RetroMTA, Tech Biosealer and TheraCal LC. It has been claimed that these materials have properties similar to those of MTA without its drawbacks. In this article, the chemical composition and the application of MTA and other BECs for vital pulp therapy (VPT), including indirect pulp cap, direct pulp cap, partial pulpotomy, pulpotomy and partial pulpectomy, have been reviewed and compared. Based on selected keywords, all papers regarding chemical composition and VPT applications of BECs had been reviewed. Most of the materials had calcium and silicate in their composition. Instead of referring to the cements based on their chemical compositions, we suggest the term 'bioactive endodontic cements (BECs)', which seems more appropriate for these materials because, in spite of differences in their chemical compositions, bioactivity is a common property for all of them. Numerous articles were found regarding use of BECs as VPT agents for indirect and direct pulp capping, partial pulpotomy and cervical pulpotomy. Most of these investigations used MTA for VPT. In most studies, newly introduced materials have been compared to MTA. Some of the BECs have shown promising results; however, the number of their studies compared to investigations on MTA is limited. Most studies had several methodological shortcomings. Future investigations with rigorous methods and materials are needed.

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Section: Vital Pulp Therapiesmentioning

confidence: 97%

Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part I: vital pulp therapy

2017

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“…In an in vivo study on dogs’ teeth, no colour change was reported when iRoot BP Plus was used as a pulp capping agent, whereas tooth‐coloured ProRoot MTA was associated with grey discolouration 1 week following treatment (Shi et al . ).…”

Section: Important Clinical Factors and Possible Drawbacksmentioning

confidence: 97%

Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part II: other clinical applications and complications

2017

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Mineral trioxide aggregate (MTA) is a dental material used extensively for vital pulp therapies (VPT), protecting scaffolds during regenerative endodontic procedures, apical barriers in teeth with necrotic pulps and open apices, perforation repairs as well as root canal filling and root-end filling during surgical endodontics. A number of bioactive endodontic cements (BECs) have recently been introduced to the market. Most of these materials have calcium and silicate in their compositions; however, bioactivity is a common property of these cements. These materials include the following: BioAggregate, Biodentine, BioRoot RCS, calciumenriched mixture cement, Endo-CPM, Endocem, EndoSequence, EndoBinder, EndoSeal MTA, iRoot, MicroMega MTA, MTA Bio, MTA Fillapex, MTA Plus, Neo MTA Plus, Ortho MTA, Quick-Set, Retro MTA, Tech Biosealer, and TheraCal LC. It has been claimed that these materials have properties similar to those of MTA but without the drawbacks. In Part I of this review, the available information on the chemical composition of the materials listed above was reviewed and their applications for VPT was discussed. In this article, the clinical applications of MTA and other BECs will be reviewed for apexification, regenerative endodontics, perforation repair, root canal filling, root-end filling, restorative procedures, periodontal defects and treatment of vertical and horizontal root fractures. In addition, the literature regarding the possible drawbacks of these materials following their clinical applications is reviewed. These drawbacks include their discolouration potential, systemic effects and retreatability following use as a root filling material. Based on selected keywords, all publications were searched regarding the use of MTA as well as BECs for the relevant clinical applications. Numerous publications were found regarding the use of BECs for various endodontic applications. The majority of these investigations compared BECs with MTA. Despite promising results for some materials, the number of publications using BECs for various clinical applications was limited. Furthermore, most studies had several methodological shortcomings and low levels of evidence.

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“…iRoot BP Plus was also found to be non‐toxic to human dental pulp cells and was able to induce mineralization and odontoblastic differentiation‐associated gene expression . In vitro and in vivo studies showed no significant difference in pulp response to iRoot BP Plus or MTA , consequently iRoot BP Plus might be used as a pulp capping material for vital pulp therapy . iRoot FS showed similar biocompatibility with iRoot BP Plus and ProRoot MTA, but it displayed the best cell adhesion capacity in both L929 and MG63 cells among iRoot BP Plus, ProRoot MTA and Super‐EBA .…”

Section: Bioceramic Cementsmentioning

confidence: 98%

Bioceramic materials in endodontics

Wang¹

2015

Endodontic Topics

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During the past two decades, a number of major advances have been made in the field of bioactive ceramics used for endodontic treatment. This article reviews the physico‐chemical and biological properties of bioceramic materials and the application of bioceramic technology to endodontics. Bioceramic materials, with their biocompatible nature and excellent physico‐chemical properties, are widely used in endodontic applications. They can function as cements, root repair materials, root canal sealers and filling materials, which have the advantages of enhanced biocompatibility, potential increased root strength following obturation, antibacterial properties and sealing ability. New bioceramic materials have demonstrated the ability to overcome some of the significant limitations of earlier generations of endodontic materials. Most bioceramic materials have been shown to be biocompatible and have good physico‐chemical characteristics, therefore having a potential use in clinical endodontics. Although in vitro studies on the use of bioceramic materials in endodontics have given encouraging results, randomized and double‐blind clinical studies of sufficient length with these materials are needed to confirm long‐term success following their use.

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Comparison of in vivo dental pulp responses to capping with iRoot BP Plus and mineral trioxide aggregate

Abstract: iRoot BP Plus and MTA had similar favourable results when used as pulp-capping agents.

Cited by 55 publications

References 26 publications

Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part I: vital pulp therapy

Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part I: vital pulp therapy

Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part II: other clinical applications and complications

Bioceramic materials in endodontics

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