Comparison of Hypotensive Action of Sodium Azide in Normotensive and Hypertensive Patients.

Black, Max; Zweifach, Benjamin W.; Speer, Francis D.

doi:10.3181/00379727-85-20770

Cited by 31 publications

(19 citation statements)

References 2 publications

(2 reference statements)

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“…This may in part be explained by significant differences which exist in the "sensitivity" of different individuals to the effects of sodium azide. 8 Further industrial hygiene and medical evaluations are needed to more accurately assess the exposure-response relationship for sodium azide.…”

Section: Discussionmentioning

confidence: 99%

“…9 Studies of sodium azide as a hypotensive agent revealed that 0.65 -1.3 mg, administered orally, can cause hypotension among hypertensive humans. 8 The basis for the current limits of exposure involves the known hypotensive action of sodium azide at low levels combined with a "reasonable" margin of safety. 18 It is not clear why, given the exposures to sodium azide and hydrazoic acid which were documented in our evaluation, relatively few symptoms were reported during our site visit.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 Exposure to NaN 3 and hydrazoic acid, at levels causing hypotension, has not been reported to be associated with any permanent adverse effects. 8,9 Ingestion of larger amounts of NaN 3 results in a variety of adverse effects and can be fatal. 10,11 Skin absorption of NaN 3 has been reported in animal studies 12,13 but is not well understood in humans.…”

Section: Sodium Azidementioning

confidence: 99%

See 2 more Smart Citations

Health hazard evaluation report: HETA-95-0023-2531, American Azide Corporation, Cedar City, Utah.

Esswein¹,

Trout²,

Hales³

1995

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Sodium Azidementioning

confidence: 99%

See 1 more Smart Citation

Health hazard evaluation report: HETA-95-0023-2531, American Azide Corporation, Cedar City, Utah.

Esswein¹,

Trout²,

Hales³

1995

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“…The salt is also employed against hypertension in case of emergency [42] and as a nitrification inhibitor [43].…”

Section: Application Of Sodium Azidementioning

confidence: 99%

“…Imidazole-1-sulfonyl azide is the reagent of choice [72] for diazo transfer (Regitz diazo transfer [42]), whereas trisyl azide [41] has been used for azide transfer onto enolates.…”

Section: Organic Reactions Of Azidesmentioning

confidence: 99%

Hydrazoic Acid and Azides

Bräse

Mende

Jobelius³

et al. 2015

Ullmann's Encyclopedia of Industrial Chemistry

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Exposures and health effects: An evaluation of workers at a sodium azide production plant

et al. 1996

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Sodium azide is the principal gas‐generating agent used to inflate automobile supplemental restraint systems, more commonly called airbags. Although sodium azide is known to affect the cardiovascular system by causing peripheral vasodilation, there is no published literature describing occupational exposures to sodium azide in the rapidly growing automobile airbag industry. In 1994–1995, the National Institute for Occupational Safety and Health (NIOSH) conducted a cross‐sectional study of health complaints reported by sodium azide production workers at the only continuous sodium azide production facility in the United States. The NIOSH evaluation consisted of a plant industrial hygiene survey, a symptom questionnaire, ambulatory blood pressure monitoring, and blood azide analysis. Personal breathing zone air monitoring revealed exposures to sodium azide and hydrazoic acid (a reactant product) at levels greater than the NIOSH Recommended Exposure Limits (RELs). In some cases, exposures exceeded the REL despite the use of air‐supplied respirators. The questionnaire revealed that most workers reported headache (10 of 11 [91%]), episodes of low blood pressure (9 of 11 [82%]), and palpitations (8 of 11 [73%]) occurring in the production areas within the 6 months preceding the study. Mild headache (4 of 11 [36%]) was the only symptom reported during our 24‐hr medical survey. Ambulatory blood pressure monitoring revealed one asymptomatic employee with a drop in blood pressure (defined as a drop in systolic [at least 20 mm Hg] and diastolic [at least 10 mm Hg] blood pressure) during a period of exposure to sodium azide at a level five times the NIOSH REL. Improvements in plant engineering controls, increased attention to employee hygiene practices, and a more comprehensive respiratory protection program were recommendations made by NIOSH to reduce exposures at the plant. All facilities handling sodium aside should be aware of the potential toxicity of sodium azide and hydrazoic acid. (This article is a US Government work and, as such, is in the public domain in the United States of America.) © 1996 Wiley‐Liss, Inc.

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Comparison of Hypotensive Action of Sodium Azide in Normotensive and Hypertensive Patients.

Cited by 31 publications

References 2 publications

Health hazard evaluation report: HETA-95-0023-2531, American Azide Corporation, Cedar City, Utah.

Health hazard evaluation report: HETA-95-0023-2531, American Azide Corporation, Cedar City, Utah.

Hydrazoic Acid and Azides

Exposures and health effects: An evaluation of workers at a sodium azide production plant

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