Comparison of hypolipidemic activity of synthetic gallic acid–linoleic acid ester with mixture of gallic acid and linoleic acid, gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice

Jang, Aera; Periasamy, Sivakumar; Lee, Na Young; Song, Ha-Yeon; Lee, Ju Woon; Lee, Mooha; Jo, Cheorun

doi:10.1016/j.cbi.2008.05.018

Cited by 92 publications

(71 citation statements)

References 37 publications

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“…Thus, our results partially agree with those of Bose et al 7 and Jang et al 8 , without signifi cant differences in serum biochemical analyses, probably because the amount of DOGGA was low compared to that in the other experiments. It is noteworthy, however, that the level of DOGGA in the diet was 1/36 and 1/111 of that used by Bose et al 7 and Jang et al 8 , respectively, in studies using a HFD that contained fat equivalent to 60 energy 7 and 23.8 lard 8 , respectively, to generate obesity. Our diet contained 7 oil, to match the oil content in a standard rat diet 3 .…”

Section: Discussionsupporting

confidence: 92%

“…Bose et al 7 have reported that body weight decrease EGCG of HFD-fed mice is associated with increased fecal lipids, plasma cholesterol, etc. Jang et al 8 have proved hypolipidemic activity in GLE weight loss and decreased levels of plasma T-CHO, low-density lipoprotein cholesterol, TG, etc. but did not carry out fecal analyses.…”

Section: Discussionmentioning

confidence: 99%

“…These polyphenols are analogues of catechins and flavones, which are similar in chemical structure. GLE, to which Jang et al 8 turned their attention as an anti-obesity effector, differs from catechins and flavones in structure, however. In the present study, intact GA and OG did not clearly show weight-loss-promoting effects, whereas GA esterifi ed by 1,2-dioleoyl glycerol did.…”

Section: Discussionmentioning

confidence: 99%

“…EGCG treatment attenuated insulin resistance, plasma cholesterol, and monocyte chemoattractant protein concentrations and decreased liver weight, liver triglycerides, and plasma alanine aminotransferase concentrations. Jang et al 8 studied the effect of gallic acid GA , linoleic acid LA , a mixture of GA and LA MGL , and a chemically synthesized ester octadeca-9,12-dienyl-3,4,5-trihydroxybenzoate; GLE; GA esterifi ed by linoleyl alcohol mixed 1 in a HFD on the amelioration of hyperlipidemia in C57BL/6 mice see Fig. 1 .…”

Section: Introductionmentioning

confidence: 99%

“…Catechins and GA seem to promote weight loss, and GA ester seems more effective than intact GA. Jang et al 8 have found promise in GLE, but other combinations of GA and alcohols naturally existing in frying oil 1,2-diacyloyl glycerol for example are also interesting. In the present study, an ester, Z -3-3,4,5-trihydroxybenzoyloxy propane-1,2-diyl dioleate DOGGA , derived from GA and 1,2-dioleoyl glycerol was chemically synthesized and its weight-loss-promoting effects were compared to those of GA and OG in animal feeding experiments see Fig.…”

Section: Introductionmentioning

confidence: 99%

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Gallic Acid Glycerol Ester Promotes Weight-Loss in Rats

et al. 2011

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gallic Acid Glycerol Ester Promotes Weight-Loss in Rats

et al. 2011

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Effects of the fenugreek extracts on high‐fat diet‐fed and streptozotocin‐induced type 2 diabetic mice

Wang

et al. 2018

Anim Models and Exp Med

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Background To study the antidiabetic effects and mechanisms of the fenugreek extracts in streptozotocin ( STZ )‐induced type 2 diabetic (T2 DM ) mice fed a high‐fat diet ( HFD ). Methods We established C57 BL /6J mice model of T2 DM using HFD ‐fed and STZ ‐induced method. Then, the mice were administered with two types of fenugreek extracts (E1, flavonoid and E2, stilbene glycoside) for 4 weeks and the effects on fasting blood glucose ( FBG ), weight, superoxide dismutase ( SOD ), catalase ( CAT ), malondialdehyde ( MDA ), and pathological indexes were investigated. Results Administration of fenugreek extracts decreased the FBG level compared with that of the model group. Comparatively, the high‐dose E2 decreased the FBG more significantly than the other treatments did. Both extracts showed an obvious antioxidant effect by increasing serum SOD and CAT activities and decreasing the MDA content. Furthermore, the high‐dose E1 showed a significant difference ( P < .01) compared with the model group in the three investigated indexes. Conclusion Our study demonstrated that both the flavonoid and stilbene glycoside extracts of fenugreek improved the hyperglycemia in the T2 DM mice model. Moreover, the antidiabetic effects of both extracts might be due to their antioxidant activity in vivo.

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The effects of pomegranate (Punica granatum) on nonalcoholic fatty liver disease: A systematic review of in vivo interventional studies

Tangestani,

Jamshidi,

Farhadi

et al. 2024

Phytotherapy Research

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Nonalcoholic fatty liver disease (NAFLD) is a disorder in which excess fat accumulates in hepatocytes and can lead to serious complications. Oxidative stress is one of the leading causes of NAFLD. Pomegranates are considered antioxidant‐rich fruit. This systematic review study was aimed to investigate the impact of pomegranate on NAFLD. PubMed, Scopus, and Google Scholar databases/search engines (from inception up to July 2023) were searched for interventional studies (human and animal) that examined the effects of supplementation with different parts of pomegranate including fruits, peels, seeds, or flower on NAFLD outcomes. A total of 222 articles were retrieved following the initial search. After excluding duplicates, the title and abstract of 114 articles were screened. Afterward, irrelevant articles were removed and the full texts of the remaining 27 articles were reviewed. Eventually, 19 articles (16 animal and three human interventional studies) that met the inclusion criteria, published between 2009 and 2023, were included in this systematic review. Our study indicates the potential beneficial effects of different parts of pomegranate on the improvement of NAFLD. However, given that the majority of the included articles were animal studies, further investigations in the form of human clinical trials are warranted to suggest a clinical indication of such interventions.

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Comparison of hypolipidemic activity of synthetic gallic acid–linoleic acid ester with mixture of gallic acid and linoleic acid, gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice

Cited by 92 publications

References 37 publications

Gallic Acid Glycerol Ester Promotes Weight-Loss in Rats

Gallic Acid Glycerol Ester Promotes Weight-Loss in Rats

Effects of the fenugreek extracts on high‐fat diet‐fed and streptozotocin‐induced type 2 diabetic mice

The effects of pomegranate (Punica granatum) on nonalcoholic fatty liver disease: A systematic review of in vivo interventional studies

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