Comparison of hyperbaric oxygen and medical ozone therapies in a rat model of experimental distal colitis

Altinel, Ozcan; Demirbaş, Şeref; Çakır, Erdinç; Yaman, Halıl; Özerhan, İsmail Hakkı; Durán, E. Esteban; Çaycı, Tuncer; Akgül, Emin Özgür; Ersöz, Nail; Uysal, Bülent; Kurt, Bülent; Yaşar, Mehmet; Öter, Şükrü; Peker, Yusuf

doi:10.3109/00365513.2010.548875

Cited by 28 publications

(29 citation statements)

References 53 publications

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“…31,33 Recently, we have reported that OT has a preventive effect in the intestine and esophagus by decreasing tissue damage and increasing the antioxidant enzyme activity in experimental model of distal colitis, necrotizing enterocolitis, caustic esophageal burn model, acute necrotizing pancreatitis, and acetaminopheninduced nephrotoxicity. 20,[34][35][36][37][38] In conclusion, our data suggest that OT might protect kidneys against IRI by modulating a moderate oxidative and nitrosative stress, which, in turn, increases the antioxidant endogenous systems.…”

Section: Discussionmentioning

confidence: 90%

“…Protein carbonyl content (PCC) using the method of Levine et al as has already been described in our previous works. 4,5,8,20,21 Samples were analyzed for their nitrate plus nitrite (NO x ) concentrations, end products of nitric oxide degradation, by using ion chromatography (Dionex ICS -1000, Sunnyvale, CA, USA). The supernatant of the tissues was filtered using 22-nm injector filters (Sartorius Minisart, Goettingen, Germany).…”

Section: Biochemical Analysismentioning

confidence: 99%

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The Effects of Medical Ozone Therapy on Renal Ischemia/Reperfusion Injury

et al. 2012

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Section: Discussionmentioning

confidence: 90%

Section: Biochemical Analysismentioning

confidence: 99%

The Effects of Medical Ozone Therapy on Renal Ischemia/Reperfusion Injury

et al. 2012

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“…Most studies were published in Turkey except for two studies published in the United States [63,66] and one in Israel [64]. Several studies reported that HBOT reduced markers of inflammation, including TNF-alpha [61,63,66], IL-1β [63,66] and neopterin levels [56]. HBOT also decreased edema or colonic tissue weight in 4 studies [56,57,62,64].…”

Section: Resultsmentioning

confidence: 99%

Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis

Rossignol¹

2012

Med Gas Res

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BackgroundTraditionally, hyperbaric oxygen treatment (HBOT) has been used to treat a limited repertoire of disease, including decompression sickness and healing of problem wounds. However, some investigators have used HBOT to treat inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis.MethodsComprehensive searches were conducted in 8 scientific databases through 2011 to identify publications using HBOT in IBD. Human studies and animal models were collated separately.ResultsThirteen studies of HBOT in Crohn's disease and 6 studies in ulcerative colitis were identified. In all studies, participants had severe disease refractory to standard medical treatments, including corticosteroids, immunomodulators and anti-inflammatory medications. In patients with Crohn's disease, 31/40 (78%) had clinical improvements with HBOT, while all 39 patients with ulcerative colitis improved. One study in Crohn's disease reported a significant decrease in proinflammatory cytokines (IL-1, IL-6 and TNF-alpha) and one study in ulcerative colitis reported a decrease in IL-6 with HBOT. Adverse events were minimal. Twelve publications reported using HBOT in animal models of experimentally-induced IBD, including several studies reporting decreased markers of inflammation or immune dysregulation, including TNF-alpha (3 studies), IL-1beta (2 studies), neopterin (1 study) and myeloperoxidase activity (5 studies). HBOT also decreased oxidative stress markers including malondialdehyde (3 studies) and plasma carbonyl content (2 studies), except for one study that reported increased plasma carbonyl content. Several studies reported HBOT lowered nitric oxide (3 studies) and nitric oxide synthase (3 studies) and one study reported a decrease in prostaglandin E2 levels. Four animal studies reported decreased edema or colonic tissue weight with HBOT, and 8 studies reported microscopic improvements on histopathological examination. Although most publications reported improvements with HBOT, some studies suffered from limitations, including possible publication and referral biases, the lack of a control group, the retrospective nature and a small number of participants.ConclusionsHBOT lowered markers of inflammation and oxidative stress and ameliorated IBD in both human and animal studies. Most treated patients were refractory to standard medical treatments. Additional studies are warranted to investigate the effects of HBOT on biomarkers of oxidative stress and inflammation as well as clinical outcomes in individuals with IBD.

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“…Ozone theraphy had an improving effect on oxidant/antioxidant status and a healing effect on the histopathological changes of tissues with acute distal colitis 26 . Ozone administration significantly reduced the severity of ADC in rats.…”

Section: Discussionmentioning

confidence: 99%

Medical ozone treatment ameliorates the acute distal colitis in rat

et al. 2016

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PURPOSE:To investigate the effect of medical ozone treatment on the experimental acute distal colitis in rats. METHODS:Eighteen rats were randomly distributed into three equal groups; control, acute distal colitis (ADC) without and with medical ozone treatment. Rats in the control group were taken saline. ADC was performed by rectal way with 4% acetic acid in groups 2 and 3, and the group 3 was treated with medical ozone for three weeks both rectally and intraperitoneally. At the twenty second day the distal colons samples were obtained for malondialdehyde and myeloperoxidase, blood samples were obtained to measure the levels of TNF-α and IL-1β levels. Histolopatological examination was evaluated with Ki-67, IL-1β and VEGF immunostaining densities. RESULTS:There was significant increase in tissue MDA, MPO activity, TNF-α and IL-1β after ozone administration. There was also a significant difference at immunostaining densities of histopathological examination. CONCLUSIONS:Medical ozone treatment ameliorated the experimental acute distal colitis induced by acetic acid in rats. Its possible effect is by means of decreasing inflammation, edema, and affecting the proliferation and the vascularization.

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Comparison of hyperbaric oxygen and medical ozone therapies in a rat model of experimental distal colitis

Cited by 28 publications

References 53 publications

The Effects of Medical Ozone Therapy on Renal Ischemia/Reperfusion Injury

The Effects of Medical Ozone Therapy on Renal Ischemia/Reperfusion Injury

Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis

Medical ozone treatment ameliorates the acute distal colitis in rat

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