After a brief description of microstrip and pixel detectors for radiation imaging with X‐rays and gamma‐rays, the functionality, physical response, and imaging performance of the hybrid pixel detectors based on the Medipix1 photon counting chip for such diverse imaging applications such as digital mammography, synchrotron X‐ray radiation, nuclear medicine, and so on are described. It is concluded that such hybrid pixel detectors, originated from high‐energy physics, have great potential for specific scientific and industrial X‐ and gamma‐ray imaging applications and that the fabrication of large detector arrays or mosaic of detectors for large area imaging is still the main open problem with hybrid detectors.