Comparison of hybrid FDG PET/MRI compared with PET/CT in colorectal cancer staging and restaging: a pilot study

Paspulati, Raj Mohan; Partovi, Sasan; Herrmann, Karin; Krishnamurthi, Smitha; Delaney, Conor P.; Nguyen, Nghi

doi:10.1007/s00261-015-0474-0

Cited by 66 publications

(46 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, we confirmed the propensity for slightly higher SUVs on PET/MRI than on PET/CT (15,16,22,23). The underlying reasons are not yet completely understood, but it is assumed that in addition to differences in scanner technology, biologic factors may play a role.…”

Section: Discussionsupporting

confidence: 61%

Comparative Performance of ¹⁸F-FDG PET/MRI and ¹⁸F-FDG PET/CT in Detection and Characterization of Pulmonary Lesions in 121 Oncologic Patients

et al. 2016

View full text Add to dashboard Cite

Our objective was to compare 18 F-FDG PET/MRI (performed using a contrast-enhanced T1-weighted fat-suppressed volume-interpolated breath-hold examination [VIBE]) with 18 F-FDG PET/CT for detecting and characterizing lung lesions in oncologic patients. Methods: In 121 oncologic patients with 241 lung lesions, PET/MRI was performed after PET/CT in a single-injection protocol (260 ± 58 MBq of 18 F-FDG). The detection rates were computed for MRI, the PET component of PET/CT, and the PET component of PET/MRI in relation to the CT component of PET/CT. Wilcoxon testing was used to assess differences in lesion contrast (4-point scale) and size between morphologic datasets and differences in image quality (4-point scale), SUV mean , SUV max , and characterization (benign/malignant) between PET/MRI and PET/CT. Correlation was determined using the Pearson coefficient (r) for SUV and size and the Spearman rank coefficient (ρ) for contrast. Results: The detection rates for MRI, the PET component of PET/CT, and the PET component of PET/MRI were 66.8%, 42.7%, and 42.3%, respectively. There was a strong correlation in size (r 5 0.98) and SUV (r 5 0.91) and a moderate correlation in contrast (ρ 5 0.48). Image quality was better for PET/CT than for PET/MRI (P , 0.001). Lesion measurements were smaller for MRI than for CT (P , 0.001). SUV max and SUV mean were significantly higher for PET/MRI than for PET/CT (P , 0.001 each). There was no significant difference in lesion contrast (P 5 0.11) or characterization (P 5 0.076). Conclusion: In the detection and characterization of lung lesions 10 mm or larger, 18 F-FDG PET/MRI and 18 F-FDG PET/CT perform comparably. Lesion size, SUV and characterization correlate strongly between the two modalities. However, the overall detection rate of PET/MRI remains inferior to that of PET/CT because of the limited ability of MRI to detect lesions smaller than 10 mm. Thus, thoracic staging with PET/MRI bears a risk of missing small lung metastases. Pul monary lesion detection and characterization play a key role in cancer staging, as the presence of lung metastases influences therapy regimens and patient survival (1-3). CT, offering high spatial resolution of pulmonary tissue, has been regarded as the reference standard for lung lesion detection (4,5). However, because morphologic CT-based criteria have a relatively low specificity for malignant versus benign character, there has been a need for a more robust diagnostic standard. Over the last decade, 18 F-FDG PET/CT has proven successful not only in detecting pulmonary lesions but also in discriminating benign from malignant findings, taking advantage of the accurate anatomic information from CT and the functional characterization from PET in a onestop-shop examination (6-8). Yet, a major drawback of 18 F-FDG PET/CT is the low sensitivity of the PET component in pulmonary lesions smaller than 10 mm, because of motion artifacts, partialvolume effects, and the limited spatial resolution of PET (9). MRI has played only a minor role in radiologic asses...

show abstract

Section: Discussionsupporting

confidence: 61%

Comparative Performance of ¹⁸F-FDG PET/MRI and ¹⁸F-FDG PET/CT in Detection and Characterization of Pulmonary Lesions in 121 Oncologic Patients

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Accurate identification of disease involvement in mesorectal fat and/or fascia allow an accurate plan for patient management. PET/MRI also provided comparable diagnostic accuracy for N and M staging with PET/CT (true positive findings in 86 % vs. 71 %, respectively) [47]. In initial diagnosis and clinical follow-up, metastasis of colorectal cancer occurs in lymph nodes, peritoneum, and distant organ.…”

Section: Cancer In Gastrointestinal Tract and Abdomenmentioning

confidence: 80%

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

Kwon

Becker

Goo

et al. 2016

Nucl Med Mol Imaging

View full text Add to dashboard Cite

The recent advance in hybrid imaging techniques enables offering simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) in various clinical fields. 18F-fluorodeoxyglucose (FDG) PET has been widely used for diagnosis and evaluation of oncologic patients. The growing evidence from research and clinical experiences demonstrated that PET/MRI with FDG can provide comparable or superior diagnostic performance more than conventional radiological imaging such as computed tomography (CT), MRI or PET/CT in various cancers. Combined analysis using structural information and functional/molecular information of tumors can draw additional diagnostic information based on PET/MRI. Further studies including determination of the diagnostic efficacy, optimizing the examination protocol, and analysis of the hybrid imaging results is necessary for extending the FDG PET/MRI application in clinical oncology.

show abstract

“…Abdominal ve pelvik tümörlerde, yumuşak doku sarkomlarında yüksek yumuşak doku kontrastı nedeniyle MR görüntülemenin BT'ye olan üstünlüğü, bu bölgelerde primer ve metastatik tümörlerin değerlendirilmesinde PET/MR'yi PET/BT'ye göre üstün kılmaktadır (4,5,6). Kolorektal tümörlerin lokal yayılımının değerlendirilmesi, karaciğerde metastatik lezyonların sayı ve boyutlarının daha doğru biçimde saptanabilmesi, tüm vücut PET görüntüleme ile aynı seansta alınabilecek bölgesel yüksek çözünürlüklü PET/MR görüntüleri ile mümkündür.…”

Section: Sonuçlarveönerilerunclassified

Gazi Medical Faculty Nuclear Medicine Department’s Experiences for Usage of PET/MRI Between December 2015-February 2017: Clinical Examples of First 1000 Cases

Aydos¹,

Akdemir²,

Özçelik³

et al. 2017

Nts

View full text Add to dashboard Cite

Gazi Üniversitesi Tıp Fakültesi, Nükleer Tıp Anabilim Dalı'nda Aralık 2015 ile Şubat 2017 tarihleri arasında toplam 1243 PET/MR görüntülemesi yapılmış olup, bunların 306'sı tüm vücut görüntüleme, 937'si ise bölgesel görüntüleme şeklinde olmuştur. Bölgesel PET/MR görüntülemelerinde en sık yapılan ilk üç görüntüleme; beyin (nöroloji-nöroonkoloji), abdomen ve meme görüntülemeleridir. En sık PET/MR görüntülemesi yapılan ilk üç endikasyon; akciğer nodülü ve akciğer kanserleri, gastrointestinal sistem kanserleri ve meme kanserleridir. Yazıda çeşitli klinik olgu örnekleri gösterilmiştir. Tecrübelerimiz sonucunda, simültane PET/ MR'nin görüntüleme süresi nedeniyle hasta toleransının daha iyi olduğu, iyonize radyasyona daha az maruz bırakması nedeni ile pediatrik grupta tercih edilebileceği, primer/ metastatik beyin tümörlerinde, abdominopelvik tümörler ile yumuşak doku sarkomlarında yüksek rezolüsyonu nedeniyle PET/BT'ye göre daha başarılı olduğu, FDG dışı yeni ajanların multiparametrik MR ile birlikte kullanımının hastalara spesifik yaklaşım potansiyelini artırabileceği düşünülmüştür. Klinik olarak PET/MR'nin etkin biçimde kullanılabilmesi için, tüm vücut ve bölgesel görüntülemelere göre uygun endikasyonların belirlenmesi ve görüntüleme protokollerinin optimizasyonu gereklidir. Anahtar Kelimeler: Onkoloji, PET/MR, PET/BT During December 2015 and February 2017, 1243 PET/MR images had been taken in Gazi Medical Faculty Nuclear Medicine Department. From those; 306 of them were whole body imaging and 937 of them were regional imaging. Most commonly taken regional imaging areas are brain (neurology-neurooncology), abdomen and breast. When we look at the most common PET/MRI indications: lung nodules and cancers, gastrointestinal cancers and breast cancers detected. There are several clinical case examples on the article. Our experiences showed that; simultaneous PET/MR imaging tolerated better by patients due to shorter duration. In pediatric patients because of lower ionizing radiation exposure PET/MRI can be chosen. In primary/metastatic brain tumors, abdominopelvic tumors and soft tissue sarcomas PET/ MRI is better than PET/CT due to high resolution in those areas. Also multiparametric MR usage with non FDG tracers could bring specific approaches to patients. Clinically, for efficent use of PET/MRI, proper indications has to be made according to whole and regional body imaging and protocols need to optimized for imaging.

show abstract

Comparison of hybrid FDG PET/MRI compared with PET/CT in colorectal cancer staging and restaging: a pilot study

Cited by 66 publications

References 24 publications

Comparative Performance of ¹⁸F-FDG PET/MRI and ¹⁸F-FDG PET/CT in Detection and Characterization of Pulmonary Lesions in 121 Oncologic Patients

Comparative Performance of ¹⁸F-FDG PET/MRI and ¹⁸F-FDG PET/CT in Detection and Characterization of Pulmonary Lesions in 121 Oncologic Patients

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

Gazi Medical Faculty Nuclear Medicine Department’s Experiences for Usage of PET/MRI Between December 2015-February 2017: Clinical Examples of First 1000 Cases

Contact Info

Product

Resources

About

Comparison of hybrid FDG PET/MRI compared with PET/CT in colorectal cancer staging and restaging: a pilot study

Cited by 66 publications

References 24 publications

Comparative Performance of 18F-FDG PET/MRI and 18F-FDG PET/CT in Detection and Characterization of Pulmonary Lesions in 121 Oncologic Patients

Comparative Performance of 18F-FDG PET/MRI and 18F-FDG PET/CT in Detection and Characterization of Pulmonary Lesions in 121 Oncologic Patients

FDG Whole-Body PET/MRI in Oncology: a Systematic Review

Gazi Medical Faculty Nuclear Medicine Department’s Experiences for Usage of PET/MRI Between December 2015-February 2017: Clinical Examples of First 1000 Cases

Contact Info

Product

Resources

About

Comparative Performance of ¹⁸F-FDG PET/MRI and ¹⁸F-FDG PET/CT in Detection and Characterization of Pulmonary Lesions in 121 Oncologic Patients

Comparative Performance of ¹⁸F-FDG PET/MRI and ¹⁸F-FDG PET/CT in Detection and Characterization of Pulmonary Lesions in 121 Oncologic Patients