Comparison of hybrid 68Ga-PSMA PET/MRI and 68Ga-PSMA PET/CT in the evaluation of lymph node and bone metastases of prostate cancer

Abstract

Nodal and osseous metastases of PC are accurately and reliably depicted by hybrid PET/MRI using (68)Ga-PSMA-11 with very low discordance compared with PET/CT including PET-positive LNs of normal size. The correlation between PET/MRI SUVs and PET/CT SUVs was linear in LN and bone metastases but was significantly lower in control (non-metastatic) tissue.

Prostate-Specific Membrane Antigen-Radioguided Salvage Hemiablation High Intensity Focused Ultrasound for Radio-Recurrent Prostate Cancer

“…This case is a timely issue given the new evidence suggesting that the accurate staging of PSMA-ligand PET imaging and the effectiveness of hemiablation salvage HIFU in patients who present unilateral small sized local recurrence after primary radiation therapy [3,4]. Preliminary results show that hemiablation salvage HIFU is safe, feasible and associated with reduced morbidity and better functional outcomes.…”

PET/MRI: Reliability/Reproducibility of SUV Measurements

“…In most of these studies, a same-day protocol with a single injection was performed. The majority had a significant difference in uptake time between PET/ CT (commonly injected 60 min after injection) and the secondary PET/MR scan (with uptake times from 135 min [46] up to 180 min [47]). Table 6.1 summarizes results of studies comparing SUVs estimated on PET/CT and PET/MR images.…”

Multiplexed imaging for diagnosis and therapy

“…The detection limit of most anatomical imaging methods (25-50 mm 3 , equivalent to 10 6 -10 7 cancer cells 5 ) can be enhanced through multiplexing with molecular-imaging probes that show high focal uptake in tumours due to altered receptor expression or metabolism 6,7 . In earlyphase drug development in patients, multiplexing expedites the process by combining reporters for two or more pharmacological objectives: presence of target, pharmacokinetics, target engagement, modulation of downstream biochemical effects, or clinical response 8 .…”

“…As in EBT, beam positioning is a critical element in BNCT. Image-guided BNCT remains an area of active research, and current methods include prompt γ-spectroscopy (enabled by 478 keV γ-emission of 7 Li) and the incorporation of diagnostic nuclides or magnetic components into boron delivery vehicles for PET/SPECT/MRI 243 .…”

“…This has stimulated intense interest in targeted alpha therapy (TAT) for micrometastatic lesions, leukaemia and adjuvant radiotherapy, wherein extended attenuation tracks of β -radiation reduce therapeutic efficacy and increase non-target toxicity [236][237][238][239] . In clinical therapy of refractory neuroendocrine liver metastases after B* immediately decays via α-emission, simultaneously inducing a high LET and a 7 Li recoil. In essence, this constitutes a way of achieving 'activatable' high LET radiotherapy.…”