Comparison of histological grading methods in mucoepidermoid carcinoma of minor salivary glands

Qannam, Ahmed; Bello, Ibrahim O.

doi:10.4103/0377-4929.191765

Cited by 15 publications

(19 citation statements)

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“…It is unclear which grading schemes were used in all individual cases from the SEER database but the use of multiple schemes might have influenced the incidence of nodal involvement relative to grade. A recent report by Qannam et al describes the AFIP system (used in this study) as the most suitable [30]. The existence of these three grading systems will continue to contribute to inter-observer variability in the future.…”

Section: Discussionmentioning

confidence: 96%

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Mucoepidermoid carcinoma of the head and neck: CRTC1/3 MAML 2 translocation and its prognosticators

Weert

Lissenberg‐Witte

Bloemena

et al. 2021

Eur Arch Otorhinolaryngol

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Purpose Mucoepidermoid carcinoma (MEC) of the head and neck is a prevalent malignant salivary gland tumour with a reported good outcome. The aim of this study was to report the outcome in our centre. Methods A retrospective chart analysis with survival analyses was performed combined with fluorescence in situ hybridization (FISH) analysis to assess CRTC1/3 MAML 2 fusion gene presence. Results Sixty-four cases of MEC were identified. Median age at presentation was 51.4 years with a predominance for parotid gland involvement. Five, 10- and 20- year disease-free survival was 98%, 90% and 68%, respectively. Overall survival was 94%, 90% and 64%, respectively. Local recurrence was seen up to 14 years after primary diagnosis; distant metastases were diagnosed up to 17 years later. The overall recurrence rate was less than 20 per cent. CRTC1/3 MAML 2 fusion gene presence showed no survival benefit. Conclusion MEC of the head and neck has a favorable outcome with the exception of high-grade MEC. PNI and nodal involvement are not rare. CRTC1/3 MAML 2 fusion gene presence showed no survival benefit. The tendency for late onset of loco-regional and distant recurrence should not be underestimated.

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Section: Discussionmentioning

confidence: 96%

“…The existence of these three grading systems will continue to contribute to inter-observer variability in the future. Ganly et al have suggested to merely look for high mitotic rate and necrosis as these two features should predict a poorer outcome [30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Mucoepidermoid carcinoma of the head and neck: CRTC1/3 MAML 2 translocation and its prognosticators

Weert

Lissenberg‐Witte

Bloemena

et al. 2021

Eur Arch Otorhinolaryngol

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“…The aggressive behavior of MEC dictates a grade dependent treatment strategy (To et al., 2012). However, an efficient prognostic histopathological grading system is yet to be established (Qannam and Bello, 2016). Qannam in 2016 compared the commonly used grading systems for Mucoepidermoid carcinomas and reported a very low percentage of agreement across all the grading systems, especially in case of minor salivary gland MECs.…”

Section: Introductionmentioning

confidence: 99%

Assessing the prognostic significance of MUC4β in mucoepidermoid carcinoma of the salivary glands: An immunohistochemical study

Sawant

Spadigam

Dhupar

et al. 2019

Heliyon

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Objectives– Routine histopathological grading for salivary gland mucoepidermoid carcinoma (MEC) have failed to prognosticate these tumors, resulting in poor post-surgical outcomes. In developing countries, the lack of technologically advanced infrastructure curtails, efficient treatment modalities. This study aimed at determining if MUC4β can characterize salivary gland MEC and serve as a practical and inexpensive method to prognosticate salivary gland MEC.Materials and methods– Fifteen cases of archived paraffin embedded tissue blocks of mucoepidermoid carcinomas were reassessed for histopathological grading using Healey's system, modified by Batsakis and Luna and immunohistochemically evaluated for expression of MUC4β. Statistical analysis (Kappa statistics and Spearman's rho correlation coefficient) was performed to assess inter-observer reproducibility and to correlate the expression of MUC4β with the histopathological grade of the tumor.ResultsMUC4β expression is related to tumor differentiation in an inverse relationship. Two cases of high grade MEC were the exception to this rule.ConclusionOur study revealed that MUC4β alone cannot serve as a reliable prognostic marker due to its divergent tumor suppressor and oncogenic pathway. The role of MUC4β needs further evaluation and research so as to potentiate therapeutics depending upon its context dependent function, as a cancer marker or an oncogenic factor.

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“…Poroid hidradenomas which are now classified under the poroma group were excluded from the study [7]. The morphological features of MECs were also evaluated and graded using the Armed Force Institute of Pathology grading (AFIP) scheme [8]. The clinical data for the tumour groups were obtained from hospital information systems.…”

Section: Study Groupmentioning

confidence: 99%

Are there EWSR1 rearranged cutaneous hidradenomas and mucoepidermoid carcinomas of salivary glands? A FISH study and review of the literature

Bozdoğan¹,

Kadan²,

Bozdoğan³

2020

pjp

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MAML2 rearrangements have been previously described for hidradenomas and mucoepidermoid carcinomas (MEC). However, one report showed EWSR1 rearrangement in both tumours. In this study, EWSR1 and MAML2 translocation were investigated in hidradenomas and MECs. Specimens from thirteen MECs of the salivary glands and twenty hidradenomas of the skin were evaluated. Fluorescence in situ hybridisation (FISH) studies with EWSR1 and MAML2 break-apart probes were used. Forty percent of hidradenomas and 84.6% of MECs showed a positive MAML2 break signal. EWSR1 break signal was absent in hidradenomas. Only two MECs showed positive EWSR1 signal and were, thus, reclassified as clear cell carcinoma (CCC). A statistically significant relationship was also observed between clear cells containing hidradenomas and the FISH status. Despite the previous study, EWSR1 translocations could not be established in hidradenomas and MECs. The study further suggests that evaluation of EWSR1 might be obligatory for the correct diagnosis of MAML2-negative MECs to exclude the chance of CCCs. The present study also supports the notion that MAML2 can be used as a marker for hidradenomas and MECs.

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Comparison of histological grading methods in mucoepidermoid carcinoma of minor salivary glands

Cited by 15 publications

References 1 publication

Mucoepidermoid carcinoma of the head and neck: CRTC1/3 MAML 2 translocation and its prognosticators

Mucoepidermoid carcinoma of the head and neck: CRTC1/3 MAML 2 translocation and its prognosticators

Assessing the prognostic significance of MUC4β in mucoepidermoid carcinoma of the salivary glands: An immunohistochemical study

Are there EWSR1 rearranged cutaneous hidradenomas and mucoepidermoid carcinomas of salivary glands? A FISH study and review of the literature

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