Comparison of Histalog and Histamine as Stimulants for Maximal Gastric Secretion in Human Subjects and in Dogs

Ward, S; Gillespie, Iain; Passaro, Edward; Grossman, Morton I.

doi:10.1016/s0016-5085(63)80034-7

Cited by 74 publications

(15 citation statements)

References 7 publications

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“…None of the indices of acid secretion used in this study showed a significant age trend, thus differing from previous reports (Kirsner and Ford, 1955;Baron, 1963a;Grossman et al, 1963) (Table VI and Fig. 2).…”

Section: Resultscontrasting

confidence: 99%

“…body weight. A dose of this order had been found to evoke maximal secretion in similar patients (Ward et al, 1963) and in a recent report from Brazil (Zaterka and Neves, 1964). The stimulated secretion was aspirated in eight quarter hourly periods.…”

mentioning

confidence: 79%

“…Previous studies have established the dose of histalog required to produce maximal stimulation of acid secretion (Ward, Gillespie, Passaro, and Grossman, 1963;Zaterka and Neves, 1964). In the present investigation, maximal stimulation with histalog was used to compare gastric function in patients with peptic ulcer and in control subjects.…”

mentioning

confidence: 98%

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Maximal histalog test in control subjects and patients with peptic ulcer.

Wormsley¹,

Grossman²

1965

Gut

181

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Section: Resultscontrasting

confidence: 99%

mentioning

confidence: 79%

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Maximal histalog test in control subjects and patients with peptic ulcer.

Wormsley¹,

Grossman²

1965

Gut

181

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“…HISTALOG The maximal responses to subcutaneous administration of 200 mg. of histalog agree with the data reported for man by Ward et al (1963). It will be noted that the histalog response is higher than the subcutaneous maximal histamine response but lower than the peak response following continuous infusion of histamine or histamine plus mechothane, or even subcutaneous histamine plus mechothane.…”

Section: Resultssupporting

confidence: 89%

“…intramuscularly (Makhlouf et al, 1964a); (b) for histamine, 40 Htg./kg. subcutaneously (Kay, 1953); (c) for betazole hydrochloride (histalog), 200 mg. subcutaneously (Ward, Gillespie, Passaro, and Grossman, 1963).…”

Section: Methodsmentioning

confidence: 99%

A comparative study of the effects of gastrin, histamine, histalog, and mechothane on the secretory capacity of the human stomach in two normal subjects over 20 months.

Makhlouf¹,

McManus²,

Card³

1965

Gut

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EDITORIAL SYNOPSIS This is an exhaustive study of the basal and stimulated secretion of two normal subjects over a period of 20 months. The calculated maximal responses have been experimentally obtained by slow intravenous administration of massive doses of gastrin It. These studies have enabled many characteristics of gastric activity to be defined.The gastric secretory acid responses to 'maximal' stimulation by histamine or gastrin II administered subcutaneously have previously been studied in normal individuals and ulcer patients (Makhlouf, McManus, and Card, 1964a). The dose-response of a normal subject to a series of continuous infusions or to graded single intravenous injections of gastrin II have also been reported (Makhlouf, McManus, and Card, 1964b).The present paper is an extension of these studies. The secretory responses of two normal male subjects, G.M. and J.M., have now been examined over a period of 20 months. The experiments were designed to determine the pattern of secretory response in time to various gastric stimulants, singly or in combination; and the relationship of the responses of the two subjects. In a study of this kind, two important parameters against which all data are to be interpreted must first be established with sufficient accuracy, namely, a base line respresenting the spontaneous secretion, and the maximal response of the stomach which, it will be shown subsequently, is defined by the value of the asymptote of the doseresponse curve following stimulation by intravenous gastrin. The first section will deal with the way in which these parameters are established. METHODSThe procedures have already been described in our previous communications. Three points, however, are worthy of re-emphasis.1 Salivary contamination was prevented by the insertion of dental cotton pledgets in the sulci of the cheeks.2 The juice was collected every five minutes and pooled into samples corresponding to 10-minute periods for purposes of titration, except in the case of single intravenous injections of gastrin, when five-minute samples were estimated directly.3 The 'pumping' effect of deep respiration is of major importance in the accurate collection of juice over short periods, and it was used throughout.In the early experiments, the spontaneous secretion was collected for one hour. As the subjects became conditioned to the procedure, it was found that a 20-minute collection, accurately recorded, provided a sufficient indication of the spontaneous secretion.All the tests, often repeated, were performed in a random manner over a period of 20 months. Fifty tests involving administration of gastrin IL by infusion or single intravenous injection were performed, and were equally distributed between the two subjects.The range of doses delivered by continuous infusion was 0-2 to 90 4g./hr. In the case of single intravenous injections of gastrin, the range was 0 5 to 100 /tg. total dose. In earlier experiments using this latter technique, insufficient attention had been paid to the standardization of the ti...

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Gastric Secretory Activity With Reference to HC1

Sparberg¹,

Kirsner²

1964

Arch Intern Med

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Comparison of Histalog and Histamine as Stimulants for Maximal Gastric Secretion in Human Subjects and in Dogs

Cited by 74 publications

References 7 publications

Maximal histalog test in control subjects and patients with peptic ulcer.

Maximal histalog test in control subjects and patients with peptic ulcer.

A comparative study of the effects of gastrin, histamine, histalog, and mechothane on the secretory capacity of the human stomach in two normal subjects over 20 months.

Gastric Secretory Activity With Reference to HC1

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