Maximal histalog test in control subjects and patients with peptic ulcer.

Post-prandial lipase, pepsin and acid secretion of a Heidenhain pouch in the rabbit

“…We confirm the existence of a high basal acid secretion which is not specific to the rabbit since it has been described in man (Wormsley and Grossman, 1965), the rat (Komarov et al, 1944) and the pig (Meritt and , whereas it is null in carnivorous animals (Emas and Grossman, 1967 (Redfern et al, 1991 ).…”

Motor responses of the human alimentary tract to near-maximal infusions of pentagastrin.

“…This finding agrees with data reported by Wormsley et al (1966). Histamine and ametazole were given in doses known to produce maximal gastric secretory responses (Lawrie, Smith, and Forrest, 1964;Laudano and Roncorini, 1965;Wormsley and Grossman, 1965).…”

Changes in Parietal and Mucous Cell Mass in the Gastric Mucosa of Normal Subjects with Age: A Morphometric Study

“…In our experience, an increasing prevalence of atrophic, metaplastic and even dysplastic changes was observed in patients with gastric ulcer, accompanied, from the pathophysiolog ical point of view, by a progressive reduction in acid-secretory capacity and pepsinogen re lease [9], But these patients were not 'normal subjects' and our findings could actually be restricted to the specific subset of gastric ulcer patients. Similarly, a number of trials have Age-group 3 been carried out on duodenal ulcer carriers: gastric acid output was found to be high and apparently unaffected by the patient's age [ 11,16] and parietal cell mass was consistently high even in elderly subjects [ 14], This kind of study has several major drawbacks: (1) to our knowledge, there are no studies considering the gastric pathophysiology of a sufficient number of patients observed at different times of their life; (2) most investigations have been carried out, as already mentioned, on patients with peptic ulcer disease; (3) large numbers of studies were performed in north ern countries, where chronic atrophic gastritis (particularly the fundic type) is quite frequent [17][18][19], It is therefore easy to speculate that the results of these earlier studies are bur dened by a high incidence of atrophic changes and achlorhydria. Repeating the study of gas tric acid secretory capacity during aging raises a difficult problem, mostly for ethical reasons, but studies which have attempted to solve the problem of studying normal subjects are somewhat scanty, contradictory or dated.…”

“…All we know is that gastric ulcer in the elderly is slower to U nder the auspices of the R. Farini Foundationacid output was reported in subjects with no ulcer disease in the early sixties by Baron [ 10] and Wormsley and Grossman [11], a trend towards reduced acid output in the same type of patients has been reported more recently [12,13]. From the morphological point of view, Cheli and Bovero [14] have reported a significant reduction in parietal cell mass in subjects with no ulcer disease, while no reduc tion whatsoever was observed in duodenal ulcer patients.…”