Comparison of Hepatitis C Viral Loads in Patients with or without Coinfection with Different Genotypes

Schijman, Alejandro G.; Colina, Rodney; Мукомолов, С. Л.; Kalinina, Olga; García, Laura E.; Broor, Shobha; Bhupatiraju, Ajoy; Karayiannis, Peter; Khan, Baldip; Mogdasy, Cristina; Cristina, Juan

doi:10.1128/cdli.11.2.433-435.2004

Cited by 27 publications

(22 citation statements)

References 23 publications

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“…low level (< 60, 0000 IU/ml), intermediate level (60,0000-80,0000 IU/ml) and high level (> 80,0000 IU/ml). The results of our study are in line with previous findings that there are no significant differences in HCV RNA levels of both genders (Table 2) [18]. We have observed that the viral load in 29% patients was less than 600,000 IU/mL, while it was between 600,000-800,000 IU/mL in 27.83% patients and 25.22% patients had more than 800,000 IU/mL viral load.…”

Section: Discussionsupporting

confidence: 93%

Molecular epidemiology and viral load of HCV in different regions of Punjab, Pakistan

Afridi

Ali

Awan³

et al. 2014

Virol J

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BackgroundHepatitis C virus (HCV) is highly infectious pathogen which is responsible for causing Hepatitis around 200 million individuals worldwide. In Pakistan, 4.7% of HCV prevalence has been reported and HCV genotype 3a has been found to be the major source of infection in Pakistan but still there is lack of information on distribution of HCV genotypes and viral load in various geographical regions of Pakistan. Therefore, current study was designed to determine distribution of HCV genotypes as well viral load in different areas of Punjab province of Pakistan.FindingsA total of 995 serum samples were taken from those individuals in which antibodies against HCV were detected through ELISA, from different regions of Punjab i.e. Lahore 317(31.85%), Faisalabad 70(7.03%), Gujranwala 129(12.96%), Gujrat 106(10.65%), Sialkot 94(9.44%), Sargodha 60(6.03%), Mandibaha-ud-din 135(13.56%), Jhang 86(8.64%). Qualitative PCR was performed to determine viral load and genotyping was performed using Nested PCR. Chi-square test was used to determine the age and sex-wise prevalence of HCV. Out of 995 samples, 888 samples were found positive for HCV RNA. In all regions, genotype 3a showed highest prevalence (82.81%) followed by genotype 1 (3.41%), mixed genotypes (2.41%), genotype 2 (0.50%), genotype 5 (0.1%) and unclassified genotypes (10.75%). Viral load in 29.5% patients infected with genotype 3a was less than 600,000 IU/mL, while it was between 600,000-800,000 IU/mL in 27.9% patients and 25.22% patients had more than 800,000 IU/mL viral load.ConclusionHCV genotype 3a is the most prevalent genotype in various regions of Punjab. Viral load of HCV patients in these different regions of Punjab are reported for the first time. Moreover, based upon these results the Patients having viral load below 800,000 IU/mL would be expected to show better response of anti-HCV therapy.

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Section: Discussionsupporting

confidence: 93%

Molecular epidemiology and viral load of HCV in different regions of Punjab, Pakistan

Afridi

Ali

Awan³

et al. 2014

Virol J

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“…The higher proportion of untyped specimens in the RNA‐negative group (50%) when compared with the RNA‐positive‐infected group (9%) might then have resulted in type 1 infection being over‐represented in the former group. However, there is no firm evidence to show that HCV type 1 is associated with a higher viral load than HCV type non‐1 [41].…”

Section: Discussionmentioning

confidence: 99%

Does the clinical outcome of hepatitis C infection vary with the infecting hepatitis C virus type?

Harris¹,

Eldridge

Harbour

et al. 2006

Journal of Viral Hepatitis

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Whether differences in the natural history of hepatitis C virus (HCV) can be explained by differences in the infecting HCV type is unknown. The aim of this study was to investigate whether the HCV type might influence the clinical outcome of infection. Study serum samples were assembled from 749 individuals enrolled into the UK HCV National Register from which data on clinical outcomes were extracted. HCV-RNA-positive specimens were genotyped and HCV-RNA-negative specimens serotyped. Logistic regression analysis was used to investigate the independent effect of HCV type on viral clearance by comparing patients who were HCV RNA negative (n = 86) with those who were HCV RNA positive (n = 508). The same method was used to investigate whether HCV type was associated with histological stage of liver disease. The prevalence of HCV type 1 among those who cleared infection was 69% and among those who remained HCV RNA positive was 51%: Type 1 infections were more likely to be HCV RNA negative than non-1 types (OR 0.47, 95% CI 0.29-0.78, P = 0.003). Type 1 infections were also more likely to be associated with histological stage scores above the median when compared with non-1 types (OR 2.03, 95% CI 1.07-3.83, P = 0.03). In conclusion, HCV type 1 infection was more often HCV RNA negative, suggesting that spontaneous clearance may occur more commonly with this type. Among the RNA-positive infections, type 1 infection may be more aggressive than types 2/3.

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“…Moreover, dual HCV infections have been documented extensively [21,[26][27][28][29][30][31][32][33][34]. Preliminary data suggest that HCV viral-load levels are not significantly different among persons infected with a single HCV genotype than among those infected with multiple HCV genotypes [31].…”

Section: Defining Mixed Infectionsmentioning

confidence: 98%

Hepatitis C Virus Coinfection and Superinfection

Blackard

Sherman

2007

J INFECT DIS

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A hallmark of RNA viruses is their extreme genetic diversity. Within an individual, the hepatitis C virus (HCV) exists as a population of distinct but closely related viral variants, termed the "viral quasispecies." These variants may display divergent replicative capacity, cell tropism, immunologic escape, and antiviral-drug resistance. Coinfection with 2 or more distinct HCVs has been frequently documented. Moreover, several cases of HCV superinfection have been reported recently. However, few data are available regarding the clinical consequences of coinfection and superinfection, although these phenomena have important implications for HCV vaccine design and development, as well as for the efficacy of HCV therapeutic agents.

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Comparison of Hepatitis C Viral Loads in Patients with or without Coinfection with Different Genotypes

Cited by 27 publications

References 23 publications

Molecular epidemiology and viral load of HCV in different regions of Punjab, Pakistan

Molecular epidemiology and viral load of HCV in different regions of Punjab, Pakistan

Does the clinical outcome of hepatitis C infection vary with the infecting hepatitis C virus type?

Hepatitis C Virus Coinfection and Superinfection

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