Comparison of hemostatic properties between collagen and synthetic buttress materials used in staple line reinforcement in a swine splenic hemorrhage model

Spector, David L.; Perry, Zvi H.; Konobeck, Tracy; Mooradian, Daniel L.; Shikora, Scott A.

doi:10.1007/s00464-010-1331-4

Cited by 7 publications

(3 citation statements)

References 23 publications

(27 reference statements)

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“…The hemostatic mechanism of the sponges might have consisted of three aspects. First, Col induced platelet aggregation, the coagulation factor, and thrombin generation . Second, Ch quickly bonded to the red blood cells, and this resulted in a cellular hemostatic plug and the acceleration of local clot formation.…”

Section: Resultsmentioning

confidence: 99%

Preparation, characterization, and potential biomedical application of composite sponges based on collagen from silver carp skin

Chen

Huang

Guo

et al. 2014

J of Applied Polymer Sci

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To reuse fish processing waste for biomedical materials, collagen (Col) was extracted from silver carp skin, and Col–chitosan (Ch) composite sponges were prepared by a freeze‐drying method. The atomic force microscopy and electrophoresis results suggest the Col might have been type I. To obtain the optimum conditions for the manufacture of the Col–Ch sponges, the characteristics of sponges composed of different ratios of Col to Ch with different crosslinkers were evaluated. Scanning electron microscopy showed that the sponges had an interconnected network structure with porosity. Infrared spectroscopy demonstrated that intermolecular crosslinkages between Col and Ch occurred. The swelling measurements implied that all of the sponges could bind an 18‐ to 36‐fold amount of distilled water and still maintain their form and stability. When the ratio of Col to Ch was higher than 1:0.25, the swelling and degradation rate decreased with increasing Ch. Cell proliferation, hemolysis, and hemostasis assay indicated that the sponges exhibited noncytotoxicity, biocompatibility, nonhemolysis, and hemostatic efficacy. Overall, we concluded that the optimal ratio of Col and Ch for the sponges was 1:0.25, and glutaraldehyde crosslinking was more suitable than 1‐ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide hydrochloride. These results demonstrate the potential application of silver carp skin Col–Ch sponges for tissue engineering and wound dressing in non‐weight‐bearing tissue. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40998.

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Section: Resultsmentioning

confidence: 99%

Preparation, characterization, and potential biomedical application of composite sponges based on collagen from silver carp skin

Chen

Huang

Guo

et al. 2014

J of Applied Polymer Sci

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“…The better results demonstrated with bovine pericardium over an absorbable buttress may be solely due to its increased thickness (1 vs. 0.5 mm). However, in a hemostasis animal model, Spector et al [ 48 ] reported that a collagen matrix biologic buttress was superior to a synthetic buttress for promoting hemostasis and in fact performed as well as a conventional hemostasis product.…”

Section: Discussionmentioning

confidence: 99%

Clinical Benefit of Gastric Staple Line Reinforcement (SLR) in Gastrointestinal Surgery: a Meta-analysis

2015

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BackgroundThe objective of this study was to assess whether the use of staple line reinforcement (SLR) reduces staple line complications (SLC). Mechanical staple lines are essential for gastrointestinal surgery such as bariatric surgery. However, SLC, such as bleeding and leakage, still occur. The purposes of this study were to provide quantitative evidence on the relative efficacy of gastric SLR and to compare the rates of effectiveness of three commonly used methods.MethodsA search of the medical literature in English language journals identified studies from Jan 1, 2000, to Dec 31, 2013, using the following reinforcement types: (1) no reinforcement, (2) oversewing, (3) a biocompatible glycolide copolymer, and (4) bovine pericardium after gastric bypasses and sleeve gastrectomies. Types of reinforcement were compared using a random-effects model.ResultsThis meta-analysis reviewed 16,967 articles, extracting data on 56,309 patients concerning leak and 41,864 patients concerning bleeding. Over 40 % of patients had no reinforcement, resulting in the highest leak rate (2.75 %) and bleed rate (3.45 %). Overall, reinforcing with bovine pericardium had the lowest leak (1.28 %) and bleed (1.23 %) rates. Suture oversewing was better than no reinforcement but not as effective as bovine pericardium for leak (2.45 %) and bleed (2.69 %) rates. Buttressing with a biocompatible glycolide copolymer resulted in the second highest leak rate (2.61 %) and a bleed rate of 2.48 % but had significantly lower bleed rates than no reinforcement.ConclusionsSLR provided superior results for patients compared to no reinforcement for reducing SLC. Buttressing with bovine pericardium resulted in the most favorable outcomes. The effectiveness of different methods used to reinforce the staple line in gastric surgery does not appear to be equal.

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“…Various types of hemostatic agents or sponges have been explored, such as light-cured gelatin hydrogel glues, cyanoacrylate adhesives, microcrystalline collagen and collagen sponges, gelatin sponge, fibrin glue [16,17,18]. Unfortunately, each of them has its own shortcomings.…”

Section: Introductionmentioning

confidence: 99%

Effects of Chitin and Sepia Ink Hybrid Hemostatic Sponge on the Blood Parameters of Mice

2014

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Chitin and sepia ink hybrid hemostatic sponge (CTSH sponge), a new biomedical material, was extensively studied for its beneﬁcial biological properties of hemostasis and stimulation of healing. However, studies examining the safety of CTSH sponge in the blood system are lacking. This experiment aimed to examine whether CTSH sponge has negative effect on blood systems of mice, which were treated with a dosage of CTSH sponge (135 mg/kg) through a laparotomy. CTSH sponge was implanted into the abdominal subcutaneous and a laparotomy was used for blood sampling from abdominal aortic. Several kinds of blood parameters were detected at different time points, which were reflected by coagulation parameters including thrombin time (TT), prothrombin time (PT), activated partial thromboplatin time (APTT), fibrinogen (FIB) and platelet factor 4 (PF4); anticoagulation parameter including antithrombin III (AT-III); fibrinolytic parameters including plasminogen (PLG), fibrin degradation product (FDP) and D-dimer; hemorheology parameters including blood viscosity (BV) and plasma viscosity (PV). Results showed that CTSH sponge has no significant effect on the blood parameters of mice. The data suggested that CTSH sponge can be applied in the ﬁeld of biomedical materials and has potential possibility to be developed into clinical drugs of hemostatic agents.

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Comparison of hemostatic properties between collagen and synthetic buttress materials used in staple line reinforcement in a swine splenic hemorrhage model

Cited by 7 publications

References 23 publications

Preparation, characterization, and potential biomedical application of composite sponges based on collagen from silver carp skin

Preparation, characterization, and potential biomedical application of composite sponges based on collagen from silver carp skin

Clinical Benefit of Gastric Staple Line Reinforcement (SLR) in Gastrointestinal Surgery: a Meta-analysis

Effects of Chitin and Sepia Ink Hybrid Hemostatic Sponge on the Blood Parameters of Mice

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