Comparison of Hemochron and HemoTec activated coagulation time target values during percutaneous transluminal coronary angioplasty

Abstract

HemoTec and Hemochron activated coagulation time measurements cannot be used interchangeably. Appropriate target activated coagulation time ranges to determine adequate anticoagulation during coronary angioplasty need to be established for both machines; the target range for one machine should not be extrapolated to the other.

Defining the Optimal Activated Clotting Time During Percutaneous Coronary Intervention

“…As expected, an analysis of the 279 patients with ACT values recorded on the HemoTec assay suggested optimal efficacy in the range of 300 to 325 s, which is consistent with the previously defined 28% lower readings with this device. 24 Finally, among the trials, the relationship between the ACT and ischemic events at 7 days demonstrates some heterogeneity, likely reflecting minor differences in patient populations and procedure-specific factors. Although these issues may contribute some degree of uncertainty in the absolute magnitude of benefit attainable with optimal heparin dosing, overall trends in benefit are similar among the trials.…”

A comparison of arterial versus venous-activated clotting time in patients with congenital heart disease undergoing cardiac catheterization

“…Despite this difference, the ACT measurements obtained with these two instruments have a linear correlation in the usual range [9,10].…”

Clinical evaluation of a microsample coagulation analyzer, and comparison with existing techniques

“…Duplicate samples were also analyzed in a subset of 50 ACT tests on the Hemochron@ 8000 coagulation monitor. The technology employed by the HemochronB 8000 coagulation monitor has been described in detail elsewhere [9]. The Hemochron@ Jr. consists of a microprocessor-based analyzer and individual disposable test cartridges for completion of ACT + , aPTT, and PT.…”

“…These coagulation timers employ different methodology to measure ACT, and the tests are dependent on operator technique [8,9]. The Hemochron@ and Hemotec@ automated coagulation timers require the operator to hand-fill an aliquot of 0.2-2.0 ml of the blood sample into the test cartridge or tube.…”