Comparison of health-related quality-of-life measurement instruments in diabetic patients

Yordanova, S.; Petkova, Valentina; Petrova, Guenka; Dimitrov, Milen; Naseva, Emilia; Dimitrova, Maria; Petkova, E

doi:10.1080/13102818.2014.935572

Cited by 17 publications

(20 citation statements)

References 19 publications

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“…Two of them were large European multi-country studies that involved more than one CEE country [45,46]. Overall 152 reports on country level results were obtained: Austria (n=11) [47][48][49][50][51][52][53][54][55][56][57], Bulgaria (n=6) [45,46,58,59,13], Czech Republic (n=18) [60,61,45,46,[62][63][64][65][66]20,[67][68][69][70][71][72][73][74], Hungary (n=47) [11,75,76,45,[77][78][79][80][81][82][83][84][85][86]…”

Section: Search Resultsmentioning

confidence: 99%

“…Main study characteristics are displayed in Table 2. The first EQ-5D studies in CEE were published from Slovenia (2000) [170], Hungary (2001) [114], Austria and Poland (2003) [51,181], followed by Slovakia (2004) [168], the Czech Republic (2007) [70,71], Romania (2013) [45] and Bulgaria (2014) [13]. In the past 15 years, the number of publications has steadily increased in the region (Figure 2).…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…Official language versions are available for all the national languages of CEE countries. On the contrary, only very limited data is available from CEE countries using other preference-based measures such as SF-6D [12][13][14] and Health Utilities Index (HUI) [15] or directly measured utilities such as time trade-off or standard gamble [16][17][18][19]. Of note, HUI has not been validated in the national languages of CEE countries with the exception of Austria.…”

Section: Introductionmentioning

confidence: 99%

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EQ-5D in Central and Eastern Europe: 2000–2015

et al. 2016

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Increasing use of EQ-5D is observed throughout CEE. The spread of health technology assessment activities in countries seems to be reflected in the number of EQ-5D studies. However, improvement in informed use and methodological quality of reporting is needed. In jurisdictions where no national value set is available, in order to ensure comparability we recommend to apply the most frequently used UK tariff. Regional collaboration between CEE countries should be strengthened.

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Section: Search Resultsmentioning

confidence: 99%

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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EQ-5D in Central and Eastern Europe: 2000–2015

et al. 2016

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“…Diabetes affects mainly individuals aged 40-59 years, and its prevalence is different between men (15.6%) and women (10.7%) [3]. As a chronic disease, diabetes can lead to long-term microvascular and macrovascular complications [4][5][6]. It has a negative impact on individuals, affecting all spheres of life and reducing their quality of life [7,8].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Health-Related Quality of Life using the EQ-5D-3L in Individuals with Type 2 Diabetes Mellitus

Cardoso¹

2016

JDMDC

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The daily experience with type 2 diabetes mellitus (T2DM) has significant adverse effects on health-related quality of life (HRQoL). HRQoL assessment is essential for measuring the impact of the disease on the patient and selecting individualized strategies. Generic measures for assessing HRQoL are very useful because, unlike specific measurement instruments, they allow for the comparison with other instruments. The EQ-5D-3L is a generic measure and it describes HRQoL in five dimensions; mobility, self-care, usual activities, pain/discomfort and anxiety/depression, with three levels each. In Portugal, studies using the EQ-5D-3L as a generic measure to assess HRQoL in diabetic patients are scarce.Objective: To assess HRQoL in individuals with T2DM using the Portuguese version of the EQ-5D-3L.Methodology: An accidental sample of patients with T2DM (n=437) was selected at Family Health Units and healthcare centers in Coimbra, Portugal, between January 2013 and January 2014. The EQ-5D-3L was applied in interviews. The EQ-5D-3L score was calculated based on the answers to the five dimensions and the value system for the Portuguese population.Results: In this sample, 100% of the participants answered the EQ-5D-3L. The HRQoL score was 0.6772 in the EQ-5D-3L and 64.85 in the EQ-VAS. The most frequent answers to the five dimensions were no problems or some problems. The mean score of the EQ-5D-3L was significantly associated with age, male gender, high level of education, having an occupation, practicing physical activity, being single and having been diagnosed with T2DM for less time. The Cronbach alpha's value was 0.674, confirming an acceptable internal consistency. Conclusion:HRQoL levels in individuals with T2DM are lower than the national average and vary depending on sociodemographic and clinical characteristics. The EQ-5D-3L is a reliable instrument that can be used to assess the quality of life of diabetic patients and contribute to assess the patients' overall health status, adding data from the subjective dimension of self-care management.

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“…In the DR group, there were 16 males and 14 females, with an average age of 40.1 ± 15.2 (35-65) years old and an average BMI of 22.1 kg/m 2 . Study inclusion criteria conform to the T2DM and T2DM with DR diagnostic criteria published by the WHO in 2014 (Yordanova et al, 2014). Exclusion criteria included patients with other endocrine system or autoimmune diseases.…”

Section: Patientsmentioning

confidence: 99%

Th1/Th2 cytokine expression in diabetic retinopathy

2016

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ABSTRACT. Diabetic retinopathy (DR), an important complication of diabetes mellitus (DM), is not well understood. T helper cell balance (Th1/Th2) is involved in various autoimmune diseases; however, its role in DR is not understood. This study explores changes in Th1 and Th2 cytokine expression during DR. Blood samples were collected from 25 healthy volunteers (normal control group), 35 patients with type 2 DM (T2DM group) without DR, and 30 cases of T2DM patients with DR (DR group). Real-time PCR was used to measure mRNA expression of IL-2 and TNF-α, secreted from Th1 cells, and of IL-4 and IL-10, secreted from Th2 cells. We used ELISA to detect cytokine expression in serum to analyze the correlation between Th1 and Th2 cytokines. IL-2 and TNF-α mRNA and protein expression levels in the T2DM and DR groups were significantly higher than in the normal control group (P < 0.05). Compared with the T2DM group, the DR group had higher IL-2 and TNF-α levels (P < 0.05). IL-4 and IL-10 levels were lower in the DR group compared with the normal and T2DM groups (P < 0.05), while T2DM showed no difference compared with the normal control (P > 0.05). IL-2 and TNF-α were negatively correlated with IL-4 and IL-10 in the DR group, respectively. We found that Th1 cytokine secretion was higher and Th2 cytokines secretion was lower during DR, leading to a Th1/ Th2 imbalance, suggesting that Th1/Th2 imbalance is a side effect for DR occurrence and development.

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Comparison of health-related quality-of-life measurement instruments in diabetic patients

Cited by 17 publications

References 19 publications

EQ-5D in Central and Eastern Europe: 2000–2015

EQ-5D in Central and Eastern Europe: 2000–2015

Assessment of Health-Related Quality of Life using the EQ-5D-3L in Individuals with Type 2 Diabetes Mellitus

Th1/Th2 cytokine expression in diabetic retinopathy

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