Comparison of H₂-Receptor Antagonist-and Proton-Pump Inhibitor-Based Triple Regimens for the Eradication of Helicobacter Pylori in Chinese Patients with Gastritis or Peptic Ulcer

Abstract

This study compared the efficacy of an H 2 -receptor antagonist (H 2 RA)-and a proton-pump inhibitor (PPI)-based triple regimen for the eradication of Helicobacter pylori infection. Chinese patients with H. pylori-associated gastritis or peptic ulcer were randomized to receive the H 2 RAbased triple regimen (20 mg famotidine, 1.0 g amoxicillin and 0.4 g metronidazole) or the PPI-based triple regimen (20 mg omeprazole, 1.0 g amoxicillin and 0.4 g metronidazole) both twice daily for 1 or 2 weeks. Successful eradication of H. pylori was determined by the 13 C-urea breath test and gastric mucosa histology at least 4 weeks after completion of antibiotic therapy. Eradication rates were 56.0% and 76.9% for the 1-week H 2 RA-and PPI-based triple regimens, respectively, and 81.6% and 82.1% for the 2-week regimens, respectively. The H. pylori eradication rate for the 2-week H 2 RA regimen was significantly higher than that for the 1-week regimen, but there were no significant differences between the 1-and 2-week PPI regimens. The two regimens proved equally effective in eradicating H. pylori infection.

A Meta-Analysis: Comparison of Esomeprazole and Other Proton Pump Inhibitors in Eradicating <i>Helicobacter pylori</i>

“…Eradication of H. pylori can relieve the symptoms of gastrointestinal disorder and decrease the recurrence of ulcers. Increased evidence has shown that PPIs are more effective than H 2 RAs in H. pylori eradication and gastric acid suppression [26, 27]. PPIs inhibit the H + ,K + -ATPase activity of the proton pump, the final pathway for secretion of hydrochloric acid by parietal cells, and alter intragastric pH.…”

Xiao Chai Hu Tang for Peptic Ulcers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…WM has been predominately used to treat GU, but the drugs available are limited in their efficacy. For instance, proton pump inhibitors are considered efficient drugs for PU treatment [ 31 ]. However, they have many adverse effects, such as headaches, rashes, and gastrointestinal disturbances.…”

Comparison of Amoxicillin–Metronidazole Plus Famotidine or Lansoprazole for Amoxicillin–Clarithromycin–Proton Pump Inhibitor Treatment Failures for Helicobacter pylori Infection

“…Compared to strong interests in proton pump inhibitor‐based triple therapy, there is a little evidence available on eradication therapy including H 2 ‐receptor antagonist. There have been reports of excellent results acquired by H. pylori eradication using famotidine or other H 2 ‐receptor antagonists [15–20], most of which were carried out in Europe and the USA. Unfortunately very few studies were performed on Japanese patients [21,22].…”