Comparison of guar gum from different sources for the preparation of prolonged-release or colon-specific dosage forms

Acartürk, Füsun; Celkan, Armağan

doi:10.1080/10837450802572375

Cited by 8 publications

(3 citation statements)

References 21 publications

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“…These values are in accordance with what was reported by Cortés-Camargo et al [60] for the particle size of the O. ficus indica mucilage (1.64 to 2.52 µm). The particle sizes found in the O. ficus indica mucilage were smaller than those of arabic gum (37 to 790 µm) [64], jackfruit pectin (363.6 µm) [65], and guar gum (46.4-315 µm) [66].…”

Section: Z Potential and Particle Sizementioning

confidence: 76%

Comparative Analysis of the Chemical Composition and Physicochemical Properties of the Mucilage Extracted from Fresh and Dehydrated Opuntia ficus indica Cladodes

Quintero-García

Gutiérrez-Cortez

Bah

et al. 2021

Foods

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The development of sustainable extraction methods to obtain natural products constitutes a challenge for the food industry. The aim of this work was to compare yield, separation efficiency, chemical composition, and physicochemical properties of the mucilage extracted from fresh cladodes (FNM) and mucilage extracted from dehydrated cladodes (DNM) of O. ficus indica. Suspensions of fresh and dehydrated cladodes (4% w/w) were prepared for mucilage extraction by using a mechanical separation process. Subsequently, the separated mucilage was precipitated with ethyl alcohol (1:2 v/v) then, yield and separation efficiency were determined. The mucilage was characterized by measuring Z potential, viscosity, color, and texture attributes. Additionally, chemical proximate analysis, scanning electron microscopy, and thermogravimetric analysis (TGA) were conducted. No significant differences (p < 0.05) were detected in the yield and separation efficiencies between samples. Nevertheless, the dehydration process of cladodes prior to mucilage extraction increased protein, ashes, nitrogen free extract, and calcium content. The viscosity was higher in DNM than in FNM. The TGA revealed a different thermal behavior between samples. In addition, the DNM showed lower L (darkness/lightness), cohesiveness, adhesiveness, and springiness values than those of FNM. These results support that differences found between the chemical and physicochemical properties of DNM and those of FNM will determine the applications of the mucilage obtained from the O. ficus indica cladodes in the food, pharmaceutical, and cosmetic industries.

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Section: Z Potential and Particle Sizementioning

confidence: 76%

Comparative Analysis of the Chemical Composition and Physicochemical Properties of the Mucilage Extracted from Fresh and Dehydrated Opuntia ficus indica Cladodes

Quintero-García

Gutiérrez-Cortez

Bah

et al. 2021

Foods

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“…or cluster bean, is a member of the Leguminosae (Fabaceae) family and is a glactomannan storage polysaccharide, which is grown in India and the United States, and also is economically the most important of the four species in the genus. [14] Currently, the major use of the crop is for the galactomannan gum extracted from the endosperm of the seed. About 42% of the guar seed is endosperm, of which the predominant portion is mucilage or gum (guar gum).…”

Section: Introductionmentioning

confidence: 99%

Antihyperglycemic and antihyperlipidemic effects of guar gum on streptozotocin-induced diabetes in male rats

Samarghandian¹,

Hadjzadeh²,

Fatemeh³

et al. 2012

Phcog Mag

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Background:Herbal medicine is widely used in the treatment of diseases like diabetes mellitus. We investigated the effects of guar gum in diabetic rats for the reduction of the risk of diabetes and cardiovascular disease. Dietary pattern emphasizing foods high in complex carbohydrates and fiber are associated with low blood glucose and cholesterol levels.Materials and Methods:Diet containing 0%, 5%, 10% and 20% (w/w) guar gum was fed to diabetic rats for 28 days. Blood serum glucose, triglycerides, cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol levels, atherogenic index levels, body weights and food intake were monitored at 0, 7.14 and 28 days after induction of diabetes.Results:In spite of the fact that diabetes elevated blood lipids in all rats after 14 days, the guar gum diet significantly decreased the serum concentration of cholesterol, triacylglicerols and LDL-C and atherogenic index. The most significant result in this study was the reduction of blood glucose in diabetic rats treated with the guar gum diet after 28 days versus non- and glibenclamide-treated rats. The gum promoted a general improvement in the condition of the diabetic rats in body weight and food intake in comparison with nontreated rats.Conclusion:The results of this research suggest that guar gum was significantly effective in comparison with glibenclamide in the treatment of hyperlipidemia and hyperglycemia in diabetes rats. Therefore, it may be suggested as a reliable fiber in diabetic regimes in diabetic patients.

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“…Transdermal [91][92][93][94] and nasal routes [95][96][97][98][99][100][101] are the most attractive routes. Besides, colon delivery of OND was investigated [102].…”

Section: Ondansetronmentioning

confidence: 99%

Nasal route: an alternative approach for antiemetic drug delivery

Özsoy

Güngör

2011

Expert Opinion on Drug Delivery

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Due to its superiorities, the nasal route could be considered as an attractive alternative to oral and parenteral routes. To overcome the barrier properties of the nasal epithelium and to enhance transport of antiemetic drugs, several approaches, including permeation enhancers, in situ gel formulations and micro- and nanoparticulate systems, have been evaluated. The results obtained are promising and indicate that nasal formulations of some antiemetic drugs may enter the market in the near future.

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Comparison of guar gum from different sources for the preparation of prolonged-release or colon-specific dosage forms

Cited by 8 publications

References 21 publications

Comparative Analysis of the Chemical Composition and Physicochemical Properties of the Mucilage Extracted from Fresh and Dehydrated Opuntia ficus indica Cladodes

Comparative Analysis of the Chemical Composition and Physicochemical Properties of the Mucilage Extracted from Fresh and Dehydrated Opuntia ficus indica Cladodes

Antihyperglycemic and antihyperlipidemic effects of guar gum on streptozotocin-induced diabetes in male rats

Nasal route: an alternative approach for antiemetic drug delivery

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