Comparison of glomerular filtration rate measurements with the two plasma sample and single plasma sample, gamma camera Gates, creatinine clearance, and prediction equation methods in potential kidney donors with normal renal function

Aydın, Funda; Güngör, Fırat; Cengiz, Arzu; Tuncer, Murat; Mahsereci, E.; Özdem, Sebahat; Cenkçi, Mehmet; Karayalçın, Binnur

doi:10.1097/mnm.0b013e3282f1bbde

Cited by 18 publications

(18 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there is also some debate whether the Gates' method is proper for determining the GFR (34,35). Aydın et al reported that the Gates' method is weakly correlated with the TPS method (36). Nevertheless, Assadi et al revealed that the Gates' method has a good correlation with the plasma sample method and was more precise than the CG method (37).…”

Section: Discussionmentioning

confidence: 99%

Comparison of glomerular filtration rate measurements with the two-plasma sample technique using Tc-99m DTPA and other methods in donor candidates for renal transplantation

et al. 2016

View full text Add to dashboard Cite

Background/aim: Accurate measurement of glomerular filtration rate (GFR) in the evaluation of renal functions in potential kidney donors is associated with important outcomes for both the donor and recipient. We intended to determine the efficacy of various methods while estimating GFR in potential living kidney donors.Materials and methods: Fifty-three potential kidney donors (31 females, 22 males; mean age: 50.1 years) were included in this study. GFR was estimated simultaneously using the following methods: Gates' method, Cockcroft-Gault (CG) and modification of diet in renal disease (MDRD) prediction equations, and the two-plasma sample (TPS) technique. Using TPS as the reference method, the estimations of GFR with the other methods were compared with that of TPS.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of glomerular filtration rate measurements with the two-plasma sample technique using Tc-99m DTPA and other methods in donor candidates for renal transplantation

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Therefore, Gates method, as creatinine clearance, should overestimate the true GFR, and this finding has been repeatedly reported. In particular, in a population of 115 potential kidney donors with normal renal function the Gates method overestimated GFR [20]. Moreover, a recent comparison between 99mTc-DTPA clearance using the Gates method and a two-blood sample method with MDRD and CKD-EPI, in a population of renal donor candidates and oncological patients treated with nephrotoxic chemotherapy, showed that nuclear medicine methods overestimated the GFR value in comparison to creatinine based equations [21].…”

Section: Discussionmentioning

confidence: 99%

Cross-Sectional Evaluation of Kidney Function in Hospitalized Patients: Estimated GFR Versus Renal Scintigraphy

Santoro¹,

Zappulla²,

Alibrandi³

et al. 2014

Kidney Blood Press Res

View full text Add to dashboard Cite

Background/Aims: Accurate staging of chronic kidney disease (CKD) is very important. We tried to identify difference in GFR evaluation between CKD-EPI and Gates method with renal scintigraphy and which variables are associated with these differences. Methods: We retrospectively reviewed the records of 341 patients who underwent dynamic renal scintigraphy in the last 5 years. Patients were categorized according to KDIGO staging I to V, using the eGFR calculated with the CKD-EPI equation. Secondarily, we stratified patients according to treatment with renin-angiotensin system (RAS) inhibitors. Results: Gates method tends to underestimate GFR especially in CKD stage I (mean -22.2 ml/min) and II (mean -12.5 ml/min). The division in quartiles of ages showed an underestimation of GFR only in the first quartile of age (< 50 years old). Gates method underestimation of GFR was more pronounced in stage I patients treated with RAS inhibitors (mean -34.6 ml/min). The same occurs in stage II, even though to a lesser extent. Conclusion: The assessment of GFR by the Gates method must be carefully considered in the early stages of CKD, especially in younger patients. Moreover, the difference is more pronounced in patients treated with RAS inhibitors. Longitudinal studies will prove which method better predicts cardiovascular or renal events.

show abstract

“…Whichever protocol is used, it is imperative that the technique is meticulous and that the protocol is followed correctly [24]- [26]. Multiple blood sample techniques and subsequently single blood sample technique were developed to improve the accuracy of the computed GFR [27].…”

Section: Discussionmentioning

confidence: 99%

Improved Quantification of Glomerular Filtration Rate and Differential Renal Function of Ectopic Kidneys in a Dual Head Gamma Camera

Muthu¹,

Mitra²

2014

OJMI

View full text Add to dashboard Cite

Introduction: Tc-99m Di-ethylene Tri-amine Penta Acetic Acid (DTPA) renogram is an accepted method to measure Glomerular Filtration Rate (GFR) of the kidneys. The depth and position of ectopic kidneys may vary. This may lead to variation in tissue attenuation and error in the computed GFR and Differential Renal Function (DRF) of each kidney. Objective: The present study was undertaken in patients with ectopic kidneys to improve the accuracy of GFR and DRF calculation in a renogram with single injection of Tc-99m DTPA on a dual head gamma camera. Materials and Method: The study was conducted on 55 patients with ectopic kidneys. Images were acquired on a dual head gamma camera simultaneously in anterior and posterior views. Both anterior and posterior image datasets were used to compute the GFR of the ectopic kidney by Gates method. Depth correction of the ectopic kidney was done using the lateral view image. Total GFR was calculated as the sum of the anterior dataset ectopic kidney GFR and the posterior dataset normal kidney GFR. DRF was calculated again, by using the anterior dataset GFR of the ectopic kidney and posterior dataset for normal kidneys. The total GFR calculated by our method was compared to the patient's eGFR (based on serum creatinine, age and sex). Result: The GFR calculated by anterior data set in the ectopic kidney was significantly higher than that calculated by posterior dataset (p < 0.001). Similarly, the differential GFR of the ectopic kidney was higher when the anterior dataset was used (p < 0.001). The ectopic kidney GFR of 34 (61.8%) of the 55 patients was greater than 35 ml/min, whereas in 21 patients (38.2%), it was less than 35 ml/min. The total GFR calculated by using both anterior and posterior data set was compared with the eGFR; the correlation coefficient was 0.74 in patients with ectopic kidney GFR of >35 ml/min and 0.83 in those with <35ml/min. Conclusion: The GFR of ectopic kidney as calculated from the anterior data set was significantly higher in comparison to the GFR calculated from the posterior data set (p < 0.001). Using the ante-* Corresponding author.G. S. Muthu, S. Mitra 15 rior dataset GFR, the DRF values for the ectopic kidneys was also significantly higher (p < 0.001). This method improves the accuracy of the GFR and DRF values and helps to differentiate a normally functioning ectopic kidney from a poorly functioning one. Compared to the total GFR as calculated by the present method, the eGFR showed a better correlation in patients with ectopic kidney GFR < 35.0 ml/min.

show abstract

Comparison of glomerular filtration rate measurements with the two plasma sample and single plasma sample, gamma camera Gates, creatinine clearance, and prediction equation methods in potential kidney donors with normal renal function

Cited by 18 publications

References 37 publications

Comparison of glomerular filtration rate measurements with the two-plasma sample technique using Tc-99m DTPA and other methods in donor candidates for renal transplantation

Comparison of glomerular filtration rate measurements with the two-plasma sample technique using Tc-99m DTPA and other methods in donor candidates for renal transplantation

Cross-Sectional Evaluation of Kidney Function in Hospitalized Patients: Estimated GFR Versus Renal Scintigraphy

Improved Quantification of Glomerular Filtration Rate and Differential Renal Function of Ectopic Kidneys in a Dual Head Gamma Camera

Contact Info

Product

Resources

About