Comparison of free and peptide-bound pyridinoline cross-links excretion in rheumatoid arthritis and osteoarthritis

Takahashi, Mitsuru; Suzuki, Masahiko; Naitou, Kenichi; Miyamoto, Shuichi; Kushida, Kazuhiro

doi:10.1093/rheumatology/38.2.133

Cited by 20 publications

(18 citation statements)

References 2 publications

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“…Einerseits werden Demineralisationsprozesse der Wirbelkörper, die im Rahmen eines reduzierten Knochenstoffwechsels (? low turnover) auftreten sollen, vermutet, (26). Andererseits werden auch gesteigerte Abbauvorgänge im Sinne eines high turnover für das Entstehen der Osteoporose bei AS angeschuldigt (15,24,25,27).…”

Section: Collagen Breakdown In Ankylosing Spondylitis -Relationship Tunclassified

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Kollagenabbauaktivit�t bei Spondylitis ankylosans in Beziehung zu krankheitsrelevanten Daten

Bölzner

Müller²,

Bräunig³

et al. 2003

Zeitschrift f�r Rheumatologie

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Section: Collagen Breakdown In Ankylosing Spondylitis -Relationship Tunclassified

“…unerwünschte Medikamentenwirkungen könnten zusätzlich eine entscheidende Rolle spielen (9). Eine weitere Erklärungsmöglichkeit ist eine durch abnehmende Mobilität und Schmerzen verursachte Inaktivität (26).…”

Section: Collagen Breakdown In Ankylosing Spondylitis -Relationship Tunclassified

Kollagenabbauaktivit�t bei Spondylitis ankylosans in Beziehung zu krankheitsrelevanten Daten

Bölzner

Müller²,

Bräunig³

et al. 2003

Zeitschrift f�r Rheumatologie

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“…Some studies have shown an increase in the markers of bone turnover, including patients with involvement at different locations such as the hip, spine, and hand. [5][6][7][8][9][10][11][12] A study by Hunter et al [17] reported that among markers of bone turnover, BALP osteocalcin, and CTx and NTx (N-and C-terminal collagen cross-links) levels were within normal limits whereas urinary deoxypyridinoline levels were increased. Another study on patients with advanced OA (28 involving the knee and 32 involving the hip joint) showed higher serum BALP and urinary deoxypyridinoline levels.…”

Section: Discussionmentioning

confidence: 99%

“…[5] Previous studies in patients with knee, hip, spine, and hand OA revealed contradictory results for bone formation and resorption. [5][6][7][8][9][10][11][12][13] Although most of them demonstrated that biochemical markers increased in OA, [5][6][7][8][9][10][11] some reported that there was no alteration or gradual decline in bone turnover. [12,13] Osteoarthritis affects all biomechanical dynamics of the joint, resulting in functional failure.…”

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confidence: 99%

Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis

Demircioğlu

2011

Turk J Rheumatol

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Amaç: Bu çalışmada semptomatik diz osteoartriti (OA) olan hastalarda kemiğe özgü serum alkalen fosfataz düzeyi ile fonksiyonel durum arasındaki ilişki araştırıldı. Bulgular: Kemiğe özgü alkalen fosfataz değeri, hasta grubunda ortalama 13.69±4.76 mg/dl idi. Kemiğe özgü alkalen fosfataz değerleri açısından kontrol grubu ile hasta grubu arasında istatistiksel olarak anlamlı bir fark bulunmadı (p= 0.584). Hastaların %28.5'inde kemik yapım hızı yüksek idi. Kemiğe özgü alkalen fosfataz ile WOMAC tutukluk skoru arasında ise anlamlı pozitif korelasyon bulundu (p= 0.07, r= 0.340). Kemiğe özgü alkalen fosfataz ile ağrı, fiziksel fonksiyon, WOMAC total skoru ve Lequesne indeksi arasında anlamlı korelasyon bulunmadı (sırasıyla, p= 0.590, r= 0.090, p= 0.489, r= 0.107, p= 0.413, r= 0.139, p= 0.285 r= 0.70). Hastalar ve yöntemler:Sonuç: Bu çalışmada semptomatik diz osteoartriti olan hastaların yaklaşık 1 /4'ünde kemik yapım hızında artış olduğu gösterilmiştir. Kemik yapım hızı ile dizdeki tutukluk arasında anlamlı bir pozitif ilişki bulunmuştur. Ancak hastalık şiddeti ile karşılaştırıldığında kemik yapım hızı, ağrı ve fiziksel fonksiyon arasında herhangi bir ilişki gözlemlenmemiştir.Anahtar sözcükler: Diz; osteoartrit; osteogenez.Objectives: This study aims to investigate the relationship between serum levels of bone-specific alkaline phosphatase and functional status in patients with symptomatic knee osteoarthritis (OA). Patients and methods:Seventy patients (57 females, 13 males; mean age 57.5±9.3 years; range 48 to 67 years) diagnosed with knee OA based on the American College of Rheumatology (ACR) criteria and 30 age-and gender-matched healthy controls (mean age 56.4±7.5 years) were enrolled in the study. Patients were evaluated using clinical, laboratory and radiographic methods. Bone-specific alkaline phosphatase and 24-hour urinary calcium and phosphorus levels were tested to assess bone metabolism. The Lequesne index was used for the severity of disease and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used for the functional status. Results:The mean bone-specific alkaline phosphatase value was 13.69±4.76 mg/dl in the patient group. No statistically significant difference was found between the patient group and the control group in terms of bone-specific alkaline phosphatase values (p=0.584). The bone formation rate was high in 28.5% of the patients. A significantly positive correlation was found between the bone-specific alkaline phosphatase and the WOMAC stiffness scores (p=0.07, r=0.340). No significant correlation was found between the bone-specific alkaline phosphatase and the pain, physical function, and the total scores of the WOMAC and Lequesne index (p=0.590, r=0.090, p= 0.489, r= 0.107, p= 0.413, r= 0.139, p= 0.285, r= 0.70 respectively). Conclusion:In this study, an increase was shown in the bone formation rate in approximately 1 /4 of the patients with symptomatic knee osteoarthritis. A significant positive correlation was found between bone formation rate and knee stiffness...

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“…There have been two reports about the fractions of free and peptide-bound forms of pyridinoline crosslinks in arthritis. In a later study, when the correlations between the fractions of crosslinks and the parameters of RA disease activity were examined, the peptide-bound crosslinks correlated most with the disease activity of RA [86]. Muller et al investigated urinary fractions of free and peptide forms of collagen crosslinks in patients with rheumatoid arthritis, osteoarthrosis, psoriatic arthritis and in healthy volunteers [87] and found that collagen degradation in RA resulted primarily in peptide bound forms.…”

Section: The Fractions Of Free Form and Peptide-bound Form Of Pyridinmentioning

confidence: 99%

Pyridinoline, A Collagen Crosslink, As a Biochemical Marker for Arthritis

Takahashi

2007

CRR

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Pyridinoline is a crosslink synthesized in collagen that has generally been used as a biochemical marker for bone metabolism. In addition, as pyridinoline is more abundant in cartilage and synovium than in the other tissues, there is extensive literature describing pyridinoline as a biochemical marker for cartilage destruction and metabolism, or arthritis. This paper will review the use of pyridinoline as a biochemical marker for arthritis.

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Comparison of free and peptide-bound pyridinoline cross-links excretion in rheumatoid arthritis and osteoarthritis

Abstract: The menopause, RA and OA may have different effects on the urinary excretion of free and peptide-bound pyridinoline cross-links.

Cited by 20 publications

References 2 publications

Kollagenabbauaktivit�t bei Spondylitis ankylosans in Beziehung zu krankheitsrelevanten Daten

Kollagenabbauaktivit�t bei Spondylitis ankylosans in Beziehung zu krankheitsrelevanten Daten

Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis

Pyridinoline, A Collagen Crosslink, As a Biochemical Marker for Arthritis

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