Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis

Abstract

Amaç: Bu çalışmada semptomatik diz osteoartriti (OA) olan hastalarda kemiğe özgü serum alkalen fosfataz düzeyi ile fonksiyonel durum arasındaki ilişki araştırıldı. Bulgular: Kemiğe özgü alkalen fosfataz değeri, hasta grubunda ortalama 13.69±4.76 mg/dl idi. Kemiğe özgü alkalen fosfataz değerleri açısından kontrol grubu ile hasta grubu arasında istatistiksel olarak anlamlı bir fark bulunmadı (p= 0.584). Hastaların %28.5'inde kemik yapım hızı yüksek idi. Kemiğe özgü alkalen fosfataz ile WOMAC tutukluk skoru arasında ise anlamlı pozitif korelasyon bulundu (p= 0.07, r= 0.340). Kemiğe özgü alkalen fosfataz ile ağrı, fiziksel fonksiyon, WOMAC total skoru ve Lequesne indeksi arasında anlamlı korelasyon bulunmadı (sırasıyla, p= 0.590, r= 0.090, p= 0.489, r= 0.107, p= 0.413, r= 0.139, p= 0.285 r= 0.70). Hastalar ve yöntemler:Sonuç: Bu çalışmada semptomatik diz osteoartriti olan hastaların yaklaşık 1 /4'ünde kemik yapım hızında artış olduğu gösterilmiştir. Kemik yapım hızı ile dizdeki tutukluk arasında anlamlı bir pozitif ilişki bulunmuştur. Ancak hastalık şiddeti ile karşılaştırıldığında kemik yapım hızı, ağrı ve fiziksel fonksiyon arasında herhangi bir ilişki gözlemlenmemiştir.Anahtar sözcükler: Diz; osteoartrit; osteogenez.Objectives: This study aims to investigate the relationship between serum levels of bone-specific alkaline phosphatase and functional status in patients with symptomatic knee osteoarthritis (OA). Patients and methods:Seventy patients (57 females, 13 males; mean age 57.5±9.3 years; range 48 to 67 years) diagnosed with knee OA based on the American College of Rheumatology (ACR) criteria and 30 age-and gender-matched healthy controls (mean age 56.4±7.5 years) were enrolled in the study. Patients were evaluated using clinical, laboratory and radiographic methods. Bone-specific alkaline phosphatase and 24-hour urinary calcium and phosphorus levels were tested to assess bone metabolism. The Lequesne index was used for the severity of disease and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used for the functional status. Results:The mean bone-specific alkaline phosphatase value was 13.69±4.76 mg/dl in the patient group. No statistically significant difference was found between the patient group and the control group in terms of bone-specific alkaline phosphatase values (p=0.584). The bone formation rate was high in 28.5% of the patients. A significantly positive correlation was found between the bone-specific alkaline phosphatase and the WOMAC stiffness scores (p=0.07, r=0.340). No significant correlation was found between the bone-specific alkaline phosphatase and the pain, physical function, and the total scores of the WOMAC and Lequesne index (p=0.590, r=0.090, p= 0.489, r= 0.107, p= 0.413, r= 0.139, p= 0.285, r= 0.70 respectively). Conclusion:In this study, an increase was shown in the bone formation rate in approximately 1 /4 of the patients with symptomatic knee osteoarthritis. A significant positive correlation was found between bone formation rate and knee stiffness...