Comparison of free amino acids, antioxidants, soluble phenolic acids, cytotoxicity and immunomodulation of fermented mung bean and soybean

Ali, Norlaily Mohd; Yeap, Swee Keong; Yusof, Hamidah Mohd; Beh, Boon Kee; Ho, Wan Yong; Koh, Soo Peng; Abdullah, Md. Pauzi; Alitheen, Noorjahan Banu; Long, Kamariah

doi:10.1002/jsfa.7267

Cited by 49 publications

(30 citation statements)

References 49 publications

(107 reference statements)

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“…Cells were treated with samples for 48 or 72 h. MTT assay was performed to measure cytotoxicity as described previously with minor modifications. [21] DMSO (0.5%) was used as vehicle control, and CDDP was used as a positive control. Finally, the absorbance was read at 570 nm.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Anti-inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L.

Guo

Xia

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives To explore effective extraction method and to find active constituents, we investigated the biological activity of three extracts and isolated active compounds from the fruits of Piper longum L. Methods Three extracts from the fruits were obtained by reflux, ultrasonic and supercritical fluid extraction, respectively. Active compounds were isolated by the bioassay-guided method. The anti-inflammatory activity, antiproliferation activity and cytotoxicity were evaluated. The apoptosis was detected by Hoechst 33258 staining assay. The relevant proteins were investigated by Western blot assay. Key findings The anti-inflammatory activity and cytotoxicity of supercritical fluid extract (SE) were stronger than those of the other two extracts. Among all isolated compounds, the anti-inflammatory activity of eight compounds was stronger than that of indomethacin, and compounds 8, 9, 11, 14 and 15 were found to possess anti-inflammatory effect for the first time. Compounds 1, 2, 3 and 14 exhibited significant cytotoxicity against cancer cells. SE and piperine were found to reduce colony formation, inhibit cell migration and promote apoptosis through increasing cleaved PARP and the ratio of Bax/Bcl-2. Conclusions The anti-inflammatory and antitumour effects of SE were better than those of the other two extracts. The compounds responsible for the activity were elucidated. SE and piperine inhibit cell growth through apoptosis.

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Section: Cytotoxicity Assaymentioning

confidence: 99%

Anti-inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L.

Guo

Xia

et al. 2019

Journal of Pharmacy and Pharmacology

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“…Fermentation will increase the content of small molecules such as free fatty acids and amino acids (Ali et al 2016) and the isoflavone aglycone (Haron et al 2009), as well as produce bioactive peptides (Gibbs et al 2004). This is due to the enzymatic activity of microorganisms which works on the soybean substrate, for example, lactic acid bacteria (BAL), mold, and yeast (Gibbs et al 2004;Barus et al 2008).…”

Section: The Bioactive Components Of Soybeans and Tempementioning

confidence: 99%

Potential of Bioactive Components in Tempe for the Treatment of Obesity

Astawan¹,

Mardhiyyah²,

Wijaya³

2018

jgizipangan

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Obesity has become a global health issue and is one of the factors that trigger degenerative diseases. The correct food consumption management could be a solution for treating obesity. Soybean is a food that is rich in bioactive components and has antiobesity properties through various mechanisms. In Indonesia, nearly 60% of the soybeans are consumed in the form of tempe. The process of fermenting soybeans into tempe causes a bioconversion of nutrients and bioactive components, improving the active physiological abilities. The bioactive components that play a role in the treatment of obesity are isoflavones, proteins, and peptides. These bioactive components help in reducing body weight, lowering the body fat ratio and improve lipid profile. Thus, optimation and popularization of tempe as a functional food in the daily menu supported with correct tempe processing could be a solution in treating obesity.

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“…Doenjang and Cheonggukjang, two fermented soybean products, can upregulate production ratio of IFN-γ to IL-4 in stimulated splenic T-and B-lymphocytes (Lee et al, 2017). Fermented mung bean and soybean can increase IL-2 by 1.7-and 1.9-fold, and enhance IFN-γ by 15-and 18-fold, respectively (Ali et al, 2015). Oral administration of Sparassis crispa is also observed to decrease IL-4 and IL-5 secretion (Yao, Kyosuke, Takashi, & Munehiko, 2008).…”

Section: Groupsmentioning

confidence: 99%

Immune potentials of theMucor-fermented Mao-tofu and especially its soluble extracts for the normal mice

Liu

Zhao

2017

Food and Agricultural Immunology

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Mao-tofu was fermented for 6 days with a Mucor strain and extracted with pH 6.5 water and 40% ethanol to generate respective two extracts. Immune potentials of Mao-tofu and two extracts were assessed, via assessing the changes of several immune indices related to immune organs, cells, and molecules in normal mice. Compared with the unfermented tofu, Mao-tofu had somewhat higher immune activities towards the mice in all cases, indicating improved immune potential by the Mucor-mediated fermentation. More important, two extracts (especially water extract) had much higher immune activities towards the mice than Mao-tofu (P < .05). Two extracts were in dose-dependent manner to improve immune status of the mice, via increasing spleen and thymus indices, percentages of T-helper (CD4+) and T-cytotoxic (CD8+) lymphocytes in plasma, serum contents of two complements (C3 and C4) and Th1 cytokines (IL-2 and IFN-γ), but decreasing serum contents of Th2 cytokines (IL-4, IL-5, and IL-10).

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Comparison of free amino acids, antioxidants, soluble phenolic acids, cytotoxicity and immunomodulation of fermented mung bean and soybean

Cited by 49 publications

References 49 publications

Anti-inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L.

Anti-inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L.

Potential of Bioactive Components in Tempe for the Treatment of Obesity

Immune potentials of theMucor-fermented Mao-tofu and especially its soluble extracts for the normal mice

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