Comparison of four variants of a major allergen in hazelnut (Corylus avellana) Cor a 1.04 with the major hazel pollen allergen Cor a 1.01

Lüttkopf, D.; Müller, Ursula; Skov, Per Stahl; Ballmer‐Weber, Barbara; Wüthrich, B; Hansen, Kirsten; Poulsen, Lars K.; Kästner, Marion; Haustein, Dieter; Vieths, Stefan

doi:10.1016/s0161-5890(01)00087-6

Cited by 122 publications

(101 citation statements)

References 35 publications

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“…The genus is placed within the Betulaceae family of the order Fagales. In Northern Europe, pollen of birch is a major cause of hay fever complaints, as is pollen of the Fagales species hazel and alder (Breiteneder et al 1989(Breiteneder et al , 1992Lüttkopf et al 2002). The major allergen involved is Bet v 1 of which several variants exist that may differ in their allergenicity (Ferreira et al 1996(Ferreira et al , 1997Schenk et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic relationships in Betula (Betulaceae) based on AFLP markers

Schenk¹,

Thienpont

Koopman³

et al. 2008

Tree Genetics & Genomes

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The genus Betula comprises various species in boreal and temperate climate zones of the Northern Hemisphere. The taxonomy of Betula is controversial and complicated by parallel evolution of morphological traits, polyploidization events, and extensive hybridization and introgression among species. Multilocus molecular data from AFLPs were used to provide phylogenetic information. A large number of polymorphic markers (321 variable bands) were produced in 107 Betula accessions from 23 species and 11 hybrids. The AFLP results were largely congruent with the results from previously examined nuclear DNA markers. Four distinct subgenera were identified within the genus Betula. These subgenera were partly in disagreement with the traditional (but disputed) division of the genus. In addition, the results indicated several groups of conspecific taxa. The majority of the species fell within subgenus Betula and shared a high degree of similarity with B. pendula. All hybrids were associated with this group, and the AFLP data contained signals on putative parents for some of the interspecific hybrids. Subgenus Chamaebetula and part of the Neurobetula species should be merged with Betula. The subgenera Betulenta, Betulaster, and the remaining part of Neurobetula are distinct and well supported. Although our results indicate that four major taxonomic groups can be recognized within the genus Betula, the relationship between them remains unclear. This may be due to the occurrence of hybridization and introgression, which would have a homogenizing effect on the relationships between species. Naturally occurring Betula species of hybrid origin may explain the low bootstrap values within the Betula clade.

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Section: Introductionmentioning

confidence: 99%

Phylogenetic relationships in Betula (Betulaceae) based on AFLP markers

Schenk¹,

Thienpont

Koopman³

et al. 2008

Tree Genetics & Genomes

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“…The first identified allergen was a protein of 18 kDa which is present in both hazelnut kernel and hazel pollen tissue, as a homologue of the major birch pollen allergen Bet v 1 (Hirschwehr et al, 1992). This allergen, named Cor a 1, includes four isoforms: Cor a 1.01, 1.02 and 1.03 in hazel pollen, and 1.04 in hazelnut (Lüttkopf et al, 2002). Cor a 1.04 is expressed in at least four sub-isoforms, which show different allergenic properties: the isoform Cor a 1.0404 is less allergenic, maybe because of the lack of a conformational epitope.…”

Section: Hazelnutmentioning

confidence: 99%

“…In a recent study, the 18 kDa allergens from hazelnut kernel and hazel pollen tissue were cloned using sera from 43 patients with positive DBPCFC to hazelnut (Lüttkopf et al, 2002). Four recombinant variants of the major hazelnut allergen Cor a 1.04 were produced, which surprisingly showed only 63% identity and partial IgE cross-reactivity with the major hazel pollen allergen Cor a 1.01, but 85% identity with the major birch pollen allergen Bet v 1, thus demonstrating that the epitopes of hazelnut Cor a 1.04 are less related to hazel pollen than to birch pollen.…”

Section: Hazelnutmentioning

confidence: 99%

Opinion of the Scientific Panel on Dietetic products, nutrition and allergies [NDA] on a request from the Commission relating to the evaluation of allergenic foods for labelling purposes

2004

EFS2

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“…This is a mixed group with several crossreacting allergens (Asero et al 2000;Hirschwehr et al 1998). Apple (Mal d 1) (Fritsch et al 1998) Celery (Api g 1) (Bohle et al 2003) Hazelnut (Cor a 1) (Lüttkopf et al 2002) Cherry (Pru av 1) (Scheurer et al 1999 Pear (Pyr c 5) (Karamloo et al 2001) Each group has a different flowering period. The tree pollen season may start as early as January when alder and hazel trees flower, and shows a peak in April-May when birch trees flower.…”

Section: Introductionmentioning

confidence: 99%

Strategies for prevention and mitigation of hay fever

Schenk¹,

Vliet²,

Smulders³

et al. 2006

Allergy Matters

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Seasonal allergic rhinitis is a widespread disorder in westernized countries. It has a strong negative impact on the patient's health-related quality of life and is accompanied by considerable medical and economic costs. Currently, the socioeconomic interest in prevention is growing. Reducing or avoiding allergen exposure may result in a significant reduction of sensitization and mitigation of allergic complaints, and this reduction is in addition to existing medical prevention strategies. It will require good communication to (potential) patients on the importance and possibilities for reducing the contact with allergenic pollen. Longterm pollen monitoring and forecasts of the flowering period of allergenic plants are important tools in this respect. Reducing the allergenic load may prove an alternative prevention strategy. Pollen sources are heterogeneously distributed throughout the landscape and may be avoided or selectively removed. The use of selection, conventional breeding strategies or genetic modification may reduce the allergenicity of the pollen sources. Strategies that involve genetic modification are, however, likely to raise some public concern and acceptability of these strategies has to be considered.

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Comparison of four variants of a major allergen in hazelnut (Corylus avellana) Cor a 1.04 with the major hazel pollen allergen Cor a 1.01

Cited by 122 publications

References 35 publications

Phylogenetic relationships in Betula (Betulaceae) based on AFLP markers

Phylogenetic relationships in Betula (Betulaceae) based on AFLP markers

Opinion of the Scientific Panel on Dietetic products, nutrition and allergies [NDA] on a request from the Commission relating to the evaluation of allergenic foods for labelling purposes

Strategies for prevention and mitigation of hay fever

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