Comparison of flow velocity of ophthalmic artery between primary open angle glaucoma and normal tension glaucoma.

Yamazaki, Yoshio; Hayamizu, Fukuko

doi:10.1136/bjo.79.8.732

Cited by 48 publications

(24 citation statements)

References 18 publications

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“…(Table 3, 4). These results were consistent with previous reports on POAG Rankin et al 1995;Sergott et al 1994;Yamazaki & Hayamizu 1995). However, for patients with early glaucoma, we could only detect a significantly decreased PSV in nasal PCA as compared with normal subjects, implicating that hemodynamic alteration in glaucoma may occur earlier in the ciliary circulation than in the retinal circulation.…”

Section: Discussionsupporting

confidence: 93%

“…A study with transcranial Doppler ultrasound found a significantly slower mean flow velocity in NTG than in POAG (Rojanapongpun et al 1993). On the contrary, a later study with CDI found no significant difference in all flow parameters between these two groups if they were of similar age and with similar extent of field defects (Yamazaki & Hayamizu 1995). The authors of the latter suggested that the discrepancy in results might be due to different methodology, but more probably due to the difference in the extent of GON between NTG and POAG patients.…”

Section: Discussionmentioning

confidence: 88%

“…By means of CDI, decreased flow velocity and increased vascular resistance in the central retinal artery (CRA) and posterior ciliary arteries (PCA) have also been identified for patients with POAG and NTG (Butt et al 1995;Harris et al 1994;Rankin et al 1995;Sergott et al 1994;Yamazaki & Hayamizu 1995). In addition, either spontaneous or artificial elevation of intraocular pressure (IOP) was associated with decreased flow velocity and increased resistive index in the CRA and PCA (Harris et al 1996;Liu et al 1997;Trible & Anderson 1998).…”

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confidence: 99%

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Variations in ocular hemodynamics in patients with early and late glaucoma

Liu

Chiou

Chiang

et al. 1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To determine the retrobulbar hemodynamics in glaucoma patients with different degrees of optic nerve damage. Methods: Color Doppler imaging was performed in 52 patients with controlled primary open angle glaucoma (POAG) and in 25 control subjects. Glaucomatous eyes were divided into early and late groups based on the perimetry findings. Peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index of the central retinal artery (CRA) and posterior ciliary arteries (PCA) were evaluated. Results: Early glaucoma showed significantly decreased PSV in nasal PCA when compared with the normal. Late glaucoma showed significantly decreased PSV and EDV in the CRA and nasal PCA, and significantly decreased PSV in temporal PCA as compared with the control and early glaucoma. The resistive index of the CRA also increased significantly in late glaucoma. Conclusion: Eyes with advanced glaucomatous optic neuropathy were associated with more marked alterations in retrobulbar circulation than eyes with less nerve damage.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 88%

mentioning

confidence: 99%

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Variations in ocular hemodynamics in patients with early and late glaucoma

Liu

Chiou

Chiang

et al. 1999

Acta Ophthalmologica Scandinavica

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“…Conflicting results were also reported in previous studies suggesting decreased flow velocities, as well as unaltered or even higher flow values in glaucoma. [13][14][15][16][17][18][19]30,31 The OA represents the major orbital vessel and only a minor part of its blood flow reaches the optic nerve and the retina, which could explain the lack of specificity of this vessel for NTG patients in the present study.…”

Section: Discussioncontrasting

confidence: 40%

Performance of colour Doppler imaging discriminating normal tension glaucoma from healthy eyes

Plange

Kaup

Weber

et al. 2007

Eye

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Purpose Previous studies have shown decreased retrobulbar blood flow in normal tension glaucoma (NTG) compared to healthy controls. This study evaluates the ability of colour Doppler imaging (CDI) to identify patients with NTG. Methods Sixty-two patients with untreated NTG (mean age 57714 years) and 40 agematched controls (mean age 5879 years) were included in a prospective cross-sectional institutional study. Peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive indices (RI ¼ (PSV-EDV)/PSV) of the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (PCAs) were measured by means of CDI. Using receiver operating characteristic (ROC) curves, sensitivity was determined at 90% specificity. Results Patients with NTG showed significantly decreased PSV (Po0.0001) and EDV (Po0.0001) of the CRA, significantly decreased EDV of the nasal (P ¼ 0.004) and temporal (P ¼ 0.002) PCA, and significantly increased RI of the temporal (P ¼ 0.003) PCAs compared to healthy controls. Sensitivity values at 90% specificity were calculated: PSV of the CRA, 30.6%; EDV of the CRA, 48.4%; EDV of the nasal PCA, 43.9%; EDV of the temporal PCA, 45.9%; and RI of the temporal PCA, 39.3%. Conclusions The power to identify NTG using CDI reaches 48% sensitivity at 90% specificity. Further longitudinal studies are needed to determine the prognostic value of CDI in glaucoma.

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“…18,19 Other studies of glaucoma patients have shown abnormalities in blood rheology with increased blood viscosity and reduced erythrocyte deformability. 7,[20][21][22][23][24] In addition to the above clinical associations, a variety of experimental and clinical observations demonstrate circulatory aberrations of the anterior optic nerve, the peripapillary region, [25][26][27][28][29] the choroid, 27,30,31 and the retrobulbar vasculature [32][33][34][35][36][37][38][39][40] in eyes with GON. 33,[40][41][42][43] These apparent alterations in the circulation of the glaucomatous optic nerve may implicate dysfunction of vascular regulatory mechanisms.…”

Section: Glaucoma and Systemic Vascular Diseasementioning

confidence: 99%

Ischemic model of optic nerve injury

Cioffi

2006

American Journal of Ophthalmology

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Comparison of flow velocity of ophthalmic artery between primary open angle glaucoma and normal tension glaucoma.

Cited by 48 publications

References 18 publications

Variations in ocular hemodynamics in patients with early and late glaucoma

Variations in ocular hemodynamics in patients with early and late glaucoma

Performance of colour Doppler imaging discriminating normal tension glaucoma from healthy eyes

Ischemic model of optic nerve injury

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