Comparison of exposure assessment methods for occupational carcinogens in a multi-centre lung cancer case–control study

Peters, Susan; Vermeulen, Roel; Cassidy, Adrian; Mannetje, Andrea ’t; Tongeren, Martie van; Boffetta, Paolo; Straif, Kurt; Kromhout, Hans

doi:10.1136/oem.2010.055608

Cited by 88 publications

(101 citation statements)

References 25 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 Exposure based on the cumulative probability 3 intensity of exposure (unit-years). 5 Exposure based on the probability 3 intensity of exposure (unit-years) per job. 6 Trends over the exposed subjects were added only if trends over all subjects were statistically significant in the full covariate model.…”

Section: Discussionmentioning

confidence: 99%

Occupational asbestos exposure and risk of esophageal, gastric and colorectal cancer in the prospective Netherlands Cohort Study

et al. 2014

View full text Add to dashboard Cite

The evidence for an association between occupational asbestos exposure and esophageal, gastric and colorectal cancer is limited. We studied this association specifically addressing risk differences between relatively low and high exposure, risk associated with cancer subtypes, the influence of potential confounders and the interaction between asbestos and smoking in relation to cancer risk. Using the Netherlands Cohort Study (n 5 58,279 men, aged 55-69 years at baseline), asbestos exposure was estimated by linkage to a job-exposure matrix. After 17.3 years of follow-up, 187 esophageal, 486 gastric and 1,724 colorectal cancer cases were available for analysis. The models adjusted for age and family history of cancer showed that mainly (prolonged) exposure to high levels of asbestos was statistically significantly associated with risk of esophageal adenocarcinoma (EAC), total and distal colon cancer and rectal cancer. For overall gastric cancer and gastric non-cardia adenocarcinoma (GNCA), also exposure to lower levels of asbestos was associated. Additional adjustment for lifestyle confounders, especially smoking status, yielded non-significant associations with overall gastric cancer and GNCA in the multivariableadjusted model, except for the prolonged highly exposed subjects (tertile 3 vs. never: HR 2.67, 95% CI: 1.11-6.44 and HR 3.35, 95% CI: 1.33-8.44, respectively). No statistically significant additive or multiplicative interaction between asbestos and smoking was observed for any of the studied cancers. This prospective population-based study showed that (prolonged) high asbestos exposure was associated with overall gastric cancer, EAC, GNCA, total and distal colon cancer and rectal cancer.The International Agency for Research on Cancer evaluated the evidence for an association between asbestos exposure and gastric and colorectal cancer as limited, though for colorectal cancer they were evenly divided as to whether the evidence was strong enough to justify classification as sufficient. 1 For esophageal cancer, a relatively rare cancer, results of epidemiological studies on associations with asbestos are mixed and together with the fact that animal experiments do not support biological activity of asbestos at this site, the evidence was considered to be inadequate. 2 Therefore, the question remains whether asbestos entails an increased risk of developing gastrointestinal tumors, and if so, whether risk differs for relatively low and high exposure levels. As there are numerous other risk factors for gastrointestinal cancers, an additional question relates to the influence of potential confounders. Furthermore, cancer subtypes may have different etiologies and should be studied separately if possible. Finally, as for lung cancer, the question arises if interaction between asbestos and smoking is present in relation to gastrointestinal cancers. 1,2

show abstract

Section: Discussionmentioning

confidence: 99%

Occupational asbestos exposure and risk of esophageal, gastric and colorectal cancer in the prospective Netherlands Cohort Study

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Expert- and task-based information does not necessarily lead to better exposure asssessment 32. Expert-based assessment depending on self-reports or self-reported exposure has, however, the additional problem of differential misclassification because of responder bias.…”

Section: Discussionmentioning

confidence: 99%

Occupational exposures and chronic obstructive pulmonary disease: a hospital based case-control study

Govender

Lalloo

Naidoo

2011

Thorax

View full text Add to dashboard Cite

Background Occupational exposures are associated with chronic obstructive pulmonary disease (COPD). This study investigated this association among a population with a high prevalence of tuberculosis and smoking. Methods Cases (n¼110) diagnosed by pulmonologists were selected from specialist respiratory clinics. Frequency sex-and age-matched controls (n¼102) were selected from other clinics at the same institutions. Lifetime occupational exposure histories were obtained through interviews. Exposure variables derived from the ALOHA Job Exposure Matrix (JEM) were used to complement the self-reporting variables. ORs were calculated from logistic regression models, adjusting for smoking and past history of tuberculosis. Percentage population attributable risk (PAR%) was also calculated. Results The adjusted ORs for COPD from the JEMderived high cumulative biological dust exposure, high cumulative mineral dust exposure and high cumulative gas and fumes exposure were 2.1 (95% CI 1.1 to 4.2), 1.1 (95% CI 0.6 to 2.4) and 1.8 (95% CI 0.8 to 3.9), respectively. Self-reported occupational exposures were associated with higher risks, with adjusted ORs for high dust exposure-years and high chemical, gas and fumes exposure-years of 5.9 (95% CI 2.6 to 13.2) and 3.6 (95% CI 1.6 to 7.9), respectively. Among ever smokers, there was an increased risk for COPD, with ORs ranging from 5.0 to 5.5. Tuberculosis was a strong risk factor, with an OR ranging from 7.7 to 8.1. The PAR% was 25% for selfreported high exposures, but lower when the JEM variables were used. Conclusions Lifetime occupational exposures contribute to the risk of COPD, adjusted for smoking. These risks are present in populations with a high burden of tuberculosis, which is considered an important causative factor.

show abstract

“…The SYNERGY project is a consortium of international lung cancer case-control studies with information on occupational and lifetime smoking histories (7,8). More information about the SYNERGY project is available (http://synergy.iarc.fr).…”

Section: Methodsmentioning

confidence: 99%

Is Previous Respiratory Disease a Risk Factor for Lung Cancer?

Denholm

Schüz

Straif

et al. 2014

Am J Respir Crit Care Med

102

View full text Add to dashboard Cite

Comparison of exposure assessment methods for occupational carcinogens in a multi-centre lung cancer case–control study

Cited by 88 publications

References 25 publications

Occupational asbestos exposure and risk of esophageal, gastric and colorectal cancer in the prospective Netherlands Cohort Study

Occupational asbestos exposure and risk of esophageal, gastric and colorectal cancer in the prospective Netherlands Cohort Study

Occupational exposures and chronic obstructive pulmonary disease: a hospital based case-control study

Is Previous Respiratory Disease a Risk Factor for Lung Cancer?

Contact Info

Product

Resources

About