Comparison of Evaluation Methods for Disinfection Efficacy of Contact Lens Care Products

Sung, Hyung Kyung; Byun, Hyun Young; Kim, So Ra; Park, Mijung

doi:10.14479/jkoos.2014.19.1.59

Cited by 2 publications

(1 citation statement)

References 12 publications

(7 reference statements)

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“…[1,2] 황색포도상구균의 경우, 주로 정상 피부와 결막을 포함하는 점막 등에 상주하는 균으로 외상으로 손 상된 각막에서 흔히 감염을 일으킨다. [3][4][5] 또한 다른 포도 상구균과는 달리 염증주위에 섬유소막을 형성하여 면역세 포로부터 균을 보호하는 혈장응고효소(coagulase)를 생산 하며, [6] 그 외에도 백혈구에 독성 물질인 백혈구 사멸소 (lukocidin)과 용혈소(hemolysin) 등을 포함한 감염병 발생 에 중요한 많은 단백질을 만들어낸다. [7] 녹농균(Pseudomonas aeruginosa)의 경우, 소프트콘택트렌즈 착용자에게 많이 발생하여 중심성 각막궤양을 유발하는 세균이다.…”

Section: 서 론unclassified

Antibacterial Activity of Quercetin and trans-Chalcone for Application in Contact Lens Multipurpose Solution

Choi¹,

Kang²,

Han³

et al. 2016

JKOOS

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Purpose: We investigated antibacterial activities of quercetin and trans-chalcone against contact lens-related bacteria and evaluated their potential as disinfectant in contact lens multipurpose solution(MPS). Methods: Antibacterial activities of quercetin and trans-chalcone, which are flavonoids, against Staphyloccus aereus and Pseudomonas aeruginosa were determined. After trans-chalcone treatment in MPS with weak antibacterial activity, its growth inhibition effect to bacteria was also determined. Results: Both of quercetin and trans-chalcone showed antibacterial activity against S. aereus, but did not show against P. aeruginosa. As the results of MIC against S. aereus, trans-chalcone showed higher activity than quercetin (quercetin: IC 90 149 µg/ml, IC 50 31.0 µg/ml trans-chalcone: IC 90 15.2 µg/ml, IC 50 8.9 µg/ml). In the antibacterial activities experiment of MPSs, MPS of F Company showed a low activity against both S. aereus and P. aeruginosa. The antibacterial activity of the F company's MPS was investigated by adding trans-chalcone. As a result, the antibacterial activity was exhibited from 75% concentration of IC 90 (11.4 µg/ml). Conclusions: Quercetin and transchalcone, which are flavonoids, showed antibacterial activities against S. aereus and trans-chalcone had higher activity. Hence, this result suggests that quercetin and trans-chalcone can be applied to a disinfectant of MPS.

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Section: 서 론unclassified

Antibacterial Activity of Quercetin and trans-Chalcone for Application in Contact Lens Multipurpose Solution

Choi¹,

Kang²,

Han³

et al. 2016

JKOOS

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Correlation between Tear Proteins Deposition and Oxygen Transmissibility of Soft Contact Lenses

이지영¹,

이준일²,

김소라³

et al. 2017

KOOS

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In this study, the effect of lysozyme, albumin and globulin on the oxygen transmissibility of soft contact lenses was investigated. Methods: The amount of deposited protein was measured after exposing etafilcon A lens (high water content, ionic) and hilafilcon B lens (high water content, non ionic) to lysozyme, albumin and globulin solutions, respectively and the oxygen transmissibility of those lenses was measured by employing the polarographic method. Results: The amount of lysozyme deposition in etafilcon A lens was greater than 100 times compared with albumin and globulin depositions. The correlation between protein deposition and decrease in oxygen transmissibility was shown in all protein solutions, and the decrease of oxygen transmissibility caused by a large amount of lysozyme deposition was greater when the exposure time was same. However, when the same amount of tear protein was deposited, the decrease of oxygen transmissibility caused by globulin was the largest. The deposited amounts of lysozyme, albumin, and globulin in hilafilcon B lens were almost same and much smaller compared with those in etafilcon A lens, and the change in oxygen transmissibility was not significant. Hilafilcon B lens also had a correlation between the amount of globulin deposition and decrease in oxygen transmissibility. Conclusions: Therefore, it is suggested that the consideration of the amount of deposited protein in the soft contact lens as well as the type of deposited protein is necessary since the difference in oxygen transmissibility according to soft contact lens materials is related to the amount of protein deposition in the lens and globulin has the greatest effect on oxygen transmissibility.

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Comparison of Evaluation Methods for Disinfection Efficacy of Contact Lens Care Products

Cited by 2 publications

References 12 publications

Antibacterial Activity of Quercetin and trans-Chalcone for Application in Contact Lens Multipurpose Solution

Antibacterial Activity of Quercetin and trans-Chalcone for Application in Contact Lens Multipurpose Solution

Correlation between Tear Proteins Deposition and Oxygen Transmissibility of Soft Contact Lenses

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