Comparison of etomidate–remifentanil and propofol–remifentanil sedation in patients scheduled for colonoscopy

Toklu, Salime; İyilikçi, Leyla; Gönen, Can; Çiftçi, Lügen; Günenç, Ferim; Şahin, Elvan; Gökel, Erol

doi:10.1097/eja.0b013e328318c666

Cited by 41 publications

(35 citation statements)

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“…It is believed that pain, distension of colon, stretching of the mesentery, and sedation regimen provoke these symptoms [1][2][3][4][5][6][7][8][9][10]. In our study, no vasovagal reactions were observed in any patients.…”

Section: Discussionmentioning

confidence: 40%

“…Greilich et al [6] showed that all patients who received remifentanil and midazolam for colonoscopy achieved readiness for discharge in 40 minutes. Toklu et al [7] compared remifentanil + propofol and remifentanil + etomidate in patients who underwent colonoscopy under sedation and reported that the mean discharge times were 32.8 and 24.6 minutes, respectively. The mean discharge time in our study was approximately 15 minutes (15.1 vs 15.7 minutes) in both groups, which was similar to the studies that showed that the mean discharge times were around 15 minutes using moderate sedation for colonoscopy [8][9][10].…”

Section: Discussionmentioning

confidence: 99%

“…Although several trials have been performed using different anesthetic agents, the optimal combination has not yet been established [3][4][5][6][7][8][9]. In addition, some patients may require much deeper sedation with higher doses leading to cardiorespiratory depression, loss of protective reflexes, and delayed discharge [10,11].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Addition of low-dose ketamine to midazolam-fentanyl-propofol–based sedation for colonoscopy: a randomized, double-blind, controlled trial

Tuncalı

Pekcan

Celebi

et al. 2015

Journal of Clinical Anesthesia

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Section: Discussionmentioning

confidence: 40%

Section: Discussionmentioning

confidence: 99%

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Addition of low-dose ketamine to midazolam-fentanyl-propofol–based sedation for colonoscopy: a randomized, double-blind, controlled trial

Tuncalı

Pekcan

Celebi

et al. 2015

Journal of Clinical Anesthesia

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“…Deepa Kane et al 9 found delayed and prolonged sedation with propofol as compared to etomidate. This can be explained by the fact that the onset time after induction dose of propofol and etomidate is 40 s and 15-30 s, respectively while context sensitive half-life for propofol infusion up to 8 hrs is <40 min only.…”

Section: Discussionmentioning

confidence: 99%

Comparision of Etomidate versus Propofol for Anaesthesia in Short Case Surgical Procedures

Patel¹

2017

jmscr

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“…olarak bulmuş-tur. Ancak, bu sonuçların aksine Toklu ve ark (13) remifentanil ile birlikte uygulanan propofolün derlenme odasına transfer süresini belirgin düzeyde uzattığını savunmuşlardır. Newson ve ark.…”

Section: Discussionunclassified

Intermittent Bolus vs Target Controlled Infusion of Propofol Sedation for Colonoscopy

Dal¹,

İzdeş²,

Kesimci³

et al. 2011

J Turk Anaesth Int Care

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ÖZETAmaç: Elektif kolonoskopilerde, sedasyon için propofolün hedef kontrollü infüzyon veya aralıklı bolus uygulanmasının propofol tüketimi, hemodinami, işlem sırasında hasta konforu ve derlenme üzerine etkilerini karşılaştırmayı amaçladık.Gereç ve Yöntem: Çalışmaya etik kurul onayı alınan, ASA I-II, 18-65 yaş arası, 66 hasta alındı. Hastalara remifentanil 0,05 μg kg dk -1 iv başlandıktan 2 dk. sonra, propofolün hedef kontrollü infüzyonla (Grup HKİ) veya aralıklı bolus (Grup B) verilmesine göre gelişigüzel yöntemle 2 eşit gruba ayrıldı. Propofol iv yoldan; Grup HKİ'de etki yeri hedef konsantrasyonu 2 µg mL -1 , Grup B'de bolus 0,5 mg kg -1 dozda uygulandı. Ramsey Sedasyon Skalası 3-4'e ulaşana kadar Grup HKİ'de konsantrasyon 0,5 µg mL -1 artırılıp, Grup B'de 0,25 mg kg -1 propofol iv uygulandı. Hemodinami ve solunumsal parametreler, propofol tüketimi, işlemi hatırlama, rüya görme, ağrı, hasta memnuniyeti, göz açma ve derlenme zamanı kaydedildi.Bulgular: Grup HKİ'de kalp atım hızı, işlemin 1. ve 2. dk.'da (p<0,05-p<0,01); Grup B'de işlemin 5. dk.'sı hariç tüm ölçüm zamanlarda kontrol değerlerine göre anlamlı yüksekti (p<0.01). Ortalama arter basıncı işlemin 5., 6., 7. ve 8. dk.'larında Grup B'de, Grup HKİ'ye göre anlamlı yüksekti (p<0,05-p<0,01). İşlemi hatırlama, rüya görme, işlem sırasında ağrı duyma, hasta memnuniyeti, toplam propofol dozu, göz açma ve derlenme zamanı bakımından gruplar arasında anlamlı bir fark saptanmadı.Sonuç: Kolonoskopilerde sedasyon amacıyla hedef kontrollü infüzyon ile uygulanan propofolün, aralıklı bolus uygulamaya göre, ilaç tüketimi ve derlenme açısından belirgin bir üstünlük sağlamamasına karşın, işleme hemodinamik yanıtı daha iyi önlediği için seçilebileceğini düşünmekteyiz.Anahtar kelimeler: Sedasyon, anestezik, intravenöz, propofol, infüzyon; hedef kontrollü SUMMARY Intermittent Bolus vs Target Controlled Infusion of Propofol Sedation for ColonoscopyObjective: We aimed to compare the effects of propofol via target controlled infusion (TCI) or intermittent bolus (B) method on propofol consumption, hemodynamics, patient's comfort and recovery in colonoscopies.Materials and Methods: Following Ethical Committee's approval, 66 patients, (ASA I-II, 18-65 yrs) were allocated to one of two groups receiving propofol administered a either TCI or intermittent bolus (B) supplemented with remifentanil (0,05 µg kg min -1 iv). After 2 minutes, iv propofol was titrated as 0,5 µg mL -1 effect-site concentration and as 0,25 mg kg -1 bolus increments to achieve Ramsey Sedation Score of 3-4 in Groups TCI and B, respectively. Hemodynamic and respiratory parameters, total propofol requirements, the incidence of recall and dreaming, pain intensity, patient satisfaction, time to opening eyes, and also to recovery were recorded.Results: Heart rate increased significantly at first 1.-2. min in Group TCI (p<0,01), and measurements at all time-points except at 5 min in Group B (p<0,01) compared with baseline. Mean arterial pressure was significantly higher in Group B at 5., 6., 7. and 8. min than the corresp...

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Comparison of etomidate–remifentanil and propofol–remifentanil sedation in patients scheduled for colonoscopy

Abstract: Etomidate-remifentanil administration for sedation and analgesia during colonoscopy resulted in more stable haemodynamic responses and shorter recovery and discharge times.

Cited by 41 publications

References 24 publications

Addition of low-dose ketamine to midazolam-fentanyl-propofol–based sedation for colonoscopy: a randomized, double-blind, controlled trial

Addition of low-dose ketamine to midazolam-fentanyl-propofol–based sedation for colonoscopy: a randomized, double-blind, controlled trial

Comparision of Etomidate versus Propofol for Anaesthesia in Short Case Surgical Procedures

Intermittent Bolus vs Target Controlled Infusion of Propofol Sedation for Colonoscopy

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