Comparison of Estimated Glomerular Filtration Rate with Both Serum Creatinine and Cystatin C (eGFRcr-cys) versus Single Analyte (eGFRcr or eGFRcys) Using CKD-EPI and MDRD Equations in Tertiary Care Hospital Settings

Khalid, Usama; Haroon, Zujaja Hina; Aamir, Muhammad; Ain, Qurat Ul; Mansoor, Khurram; Jaffar, Syed Raza

doi:10.29271/jcpsp.2020.07.701

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…The CKD-EPI working groups also have explained the above factor, indicating that the errors due to non-GFR determinants of serum creatinine and cystatin-C are independent and smaller in the combined equation. This was further strengthened by the findings of Khalid et al (2020), which revealed a strong correlation between the creatininecystatin-C combined eGFR equation, which will be useful in the clinical diagnosis of patients with CKD.…”

Section: Methodsmentioning

confidence: 89%

Correlation of eGFR values estimated by different equations based on creatinine and cystatin-C in patients on hemodialysis treatment at Teaching Hospital Karapitiya, Galle, Sri Lanka

Wanniarachchi,

Amarasiri,

Attanayake

2023

Ceylon J. Sci.

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The present study was to compare eGFR values estimated from different equations based on creatinine and cystatin-C in patients on hemodialysis treatment. eGFR values were calculated using Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology equations based on Creatinine (CKD-EPICr) and cystatin-C values alone (CKDEPI Cys C) and by their combination (CKD-EPICr-Cys C), using 40 pre-dialysis samples. No significant differences in renal function parameters and eGFR were observed, either between male (55%) and female (45%) patients or within different age groups (p>0.05). Certain levels of agreement (p>0.05) were observed between the equations, except for the values derived from CKD-EPICys C and CKD-EPICr-Cys C (p = 0.022). Significant positive correlations were observed between all selected equations. The highest correlation was observed between CKD-EPICr and MDRD (r = 0.998, p = 0.000), whereas the lowest correlation was found between MDRD and CKD-EPICys C (r = 0.552, p = 0.000). The present findings revealed that MDRD and CKD-EPICr equations are suitable for the calculation of eGFR in routine local clinical settings for the assessment of progression of kidney impairment in patients with CKD on hemodialysis treatment. However, the use of CKD-EPICr-Cys C rather than the CKD-EPICys C is recommended as a confirmatory tool where necessary.

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Section: Methodsmentioning

confidence: 89%

Correlation of eGFR values estimated by different equations based on creatinine and cystatin-C in patients on hemodialysis treatment at Teaching Hospital Karapitiya, Galle, Sri Lanka

Wanniarachchi,

Amarasiri,

Attanayake

2023

Ceylon J. Sci.

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“…In the study, the glomerular filtration rate was assessed by the most updated CKD-EPI formula, as it better describes renal filtration, especially in lower stages (G1 and G2) of chronic kidney disease [ 13 , 14 , 15 ]. We have found that the first administration of radioisotope therapy resulted in no change in glomerular filtration in the whole study group.…”

Section: Discussionmentioning

confidence: 99%

Renal Disturbances during and after Radioligand Therapy of Neuroendocrine Tumors—Extended Analysis of Potential Acute and Chronic Complications

Saracyn¹,

Durma²,

Bober³

et al. 2023

IJMS

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Neuroendocrine tumors (NEN) are a group of neoplasms that arise from hormonal and neural cells. Despite a common origin, their clinical symptoms and outcomes are varied. They are most commonly localized in the gastrointestinal tract. Targeted radioligand therapy (RLT) is a treatment option which has proven to be successful in recent studies. However, the possible outcomes and true safety profile of the treatment need to be fully determined, especially by new, more sensitive methods. Our study aimed to present an extended analysis of acute and chronic renal complications during and after radioligand therapy using, for the first time in the literature, innovative and complex renal parameters. Forty patients with neuroendocrine tumors underwent four courses of radioligand therapy with [177Lu]Lu-DOTATATE or [177Lu]Lu/[90Y]Y-DOTATATE. Radioisotopes were administrated in intervals of 8–12 weeks, with concurrent intravenous nephroprotection. New detailed and sensitive renal parameters were used to determine the renal safety profile during and after radioisotope therapy for standard treatment of NEN. During the first and fourth courses of RLT, no change in the glomerular filtration rate (GFR) was observed. However, long-term observations one year after the treatment showed a 10% reduction in the GFR. During the first course of treatment, the fractional urea and calcium excretions increased, while the fractional potassium concentration decreased. The fractional calcium excretion remained highly increased in long-term observations. Decreases in urine IL-18, KIM-1 and albumin concentrations were observed during RLT. The concentrations of IL-18 and KIM-1 remained low even a year after therapy. The ultrasound parameters of renal perfusion changed during treatment, before partially returning to the baseline one year after therapy, and were correlated with the biochemical parameters of renal function. A permanent increase in diastolic blood pressure was correlated with the decrease in the GFR observed during the study. In this innovative and complex renal assessment during and after RLT, we found a permanent 10% per year decrease in the GFR and noticeable disturbances in renal tubule function. The diastolic blood pressure also increased.

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Acute and subacute toxicity studies of a poly herbal formulation used for diabetes

et al. 2022

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Objectives: PHF-dia (Poly Herbal Formulation Diabetes) is a polyhedral formulation possessing antihyperglycemic and antihyperlipdimic effects. This study aims to assess acute and sub-acute toxicity of PHF-dia in rats. Methods: This is an experimental study conducted in two different phases. Acute toxicity was conducted for 14 days and sub-acute toxicity was conducted for 28 days. Both studies were conducted in animal house of Jinnah University for Women, Karachi, Pakistan. Acute toxicity was evaluated in vivo with single time oral administration of 400 mg/kg and 2000 mg/kg doses for two weeks. Sub-acute toxicity was investigated with the application of repeated doses of 150 mg/kg/day, 250 mg/kg/day and 500 mg/kg/day for 28 days. Results: Acute toxicity study results showed no toxic symptoms, behavioral changes or death in rats up to 2000 mg/kg. Therefore, LD50 of oral toxic dose must be more than 2000 mg/ml. Similarly, sub-acute toxicity studies confirmed the safety of PHF-dia and showed no clinical symptoms nor biochemical or histological variation in rats treated with 150 mg/kg, 250 mg/kg and 500 mg/kg compared to the control group (p <0.05). Conclusion: This indicates safe nature of PHF-dia for the further clinical trials. However, mechanism of action of PHF-dia is not fully understood. Abbreviations:ANOVA: Analysis of variance, ALT: Alanine transaminase, AST: Aspartate transaminase,EDTA: Ethylene diamine tetra-acetic acid, H & E: Haematoxylin and Eosin,HDL: High density lipoprotein, LD50: Median lethal dose, LDL: Low density lipoprotein,PLT: Platelet count, RBC: Red blood cell, SPSS: Statistical package for social science,VLDL: Very low-density lipoprotein, WBC: White blood cell, PHF-dia (Poly Herbal Formulation Diabetes). doi: https://doi.org/10.12669/pjms.38.6.5928 How to cite this:Ghauri AO, Mohiuddin E, Rehman T, Siddiqui HSM. Acute and subacute toxicity studies of a poly herbal formulation used for diabetes. Pak J Med Sci. 2022;38(6):---------. doi: https://doi.org/10.12669/pjms.38.6.5928 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparison of Estimated Glomerular Filtration Rate with Both Serum Creatinine and Cystatin C (eGFRcr-cys) versus Single Analyte (eGFRcr or eGFRcys) Using CKD-EPI and MDRD Equations in Tertiary Care Hospital Settings

Cited by 6 publications

References 15 publications

Correlation of eGFR values estimated by different equations based on creatinine and cystatin-C in patients on hemodialysis treatment at Teaching Hospital Karapitiya, Galle, Sri Lanka

Correlation of eGFR values estimated by different equations based on creatinine and cystatin-C in patients on hemodialysis treatment at Teaching Hospital Karapitiya, Galle, Sri Lanka

Renal Disturbances during and after Radioligand Therapy of Neuroendocrine Tumors—Extended Analysis of Potential Acute and Chronic Complications

Acute and subacute toxicity studies of a poly herbal formulation used for diabetes

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