Comparison of equipotent doses of rocuronium and vecuronium

Parasa, Mrunalini; Vemuri, Nagendra Nath; Shaik, Mastan Saheb

doi:10.4103/0259-1162.150676

Cited by 7 publications

(6 citation statements)

References 12 publications

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“…Similar results were presented by Hyung Youn Kong et al in haemodynamic parameters for patients with diabetes [27]. Also regarding the use of muscle relaxants as part of the treatment of critically ill patients requiring mechanical ventilation, a significant increase (4%) in the heart rate was observed at 5 min after rocuronium administration in a dose of 0.6 mg/kg [28].…”

Section: Discussionsupporting

confidence: 85%

Effect of rocuronium on the heart rate and arterial blood pressure during combined general anaesthesia

Kościuczuk

Głuszyńska

Diemieszczyk

et al. 2021

Disaster Emerg Med J

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Section: Discussionsupporting

confidence: 85%

Effect of rocuronium on the heart rate and arterial blood pressure during combined general anaesthesia

Kościuczuk

Głuszyńska

Diemieszczyk

et al. 2021

Disaster Emerg Med J

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“…In a recent study,[ 19 ] endotracheal intubation was performed after TOF count became zero in orbicularis oculi muscle after vecuronium administration. They found the mean for onset of action of vecuronium to be 116.66 ± 55.37 s but in only 70% of patients they found favourable intubation condition.…”

Section: Discussionmentioning

confidence: 99%

A comparison of haemodynamic responses between clinical assessment-guided tracheal intubation and neuromuscular block monitoring-guided tracheal intubation: A prospective, randomised study

et al. 2017

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Background and Aims:Haemodynamic responses to laryngoscopy and endotracheal intubation and their hazards are well documented. The purpose of the study was to compare the effects of laryngoscopy and intubation on cardiovascular responses when the appropriate moment for intubation was directed by either clinical judgment or train-of-four assessment.Methods:A total of 68 patients, posted for laparoscopic cholecystectomy, were randomised into two groups. In Group M patients, the trachea was intubated after train of four counts became zero in adductor pollicis muscle, whereas in Group C patients, the trachea was intubated after the clinical judgment of jaw muscle relaxation. Changes in heart rate (HR) and mean arterial pressure, intubating conditions and the time between the administration of a neuromuscular blocking agent and endotracheal intubation were recorded. Results were analysed by the Analysis of variance and chi-square tests.Results:HR and mean arterial pressure were significantly higher in Group C as compared to Group M after laryngoscopy and tracheal intubation (P < 0.05). The mean time required for intubation was significantly shorter in Group C compared to Group M (175 ± 7 s vs. 385 ± 101 s). Excellent and good intubation conditions were observed in all Group M patients, whereas 24 out of 34 patients (70%) in Group C showed excellent and good intubation conditions.Conclusion:Haemodynamic responses to laryngoscopy and tracheal intubation can be significantly attenuated if tracheal intubation is performed following complete paralysis of laryngeal muscles, detected by neuromuscular monitoring of adductor pollicis muscle.

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“…It is contraindicated in patients with severe burns, crush injuries, severe abdominal infections, denervation syndromes, spinal cord injuries, and those with a history of malignant hyperthermia or an allergic reaction to it. So, the US Food and Drug Administration recommends that the use of succinylcholine in children should be reserved for emergency intubation and instances where immediate securing of the airway is necessary [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

A Randomized Double-Blind Comparative Study of the Intubating Conditions and Hemodynamic Effects of Rocuronium and Succinylcholine in Pediatric Patients

Kumar,

Bharti

et al. 2023

Cureus

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Background: The incidence of unanticipated difficult airways is higher in pediatric age groups than in adults due to the different airway anatomy, difficulty in airway examination, and congenital malformations. Rocuronium bromide has a comparable onset time to succinylcholine at its proportionate dose. Hence, we compared rocuronium bromide with succinylcholine to assess intubating conditions and their side effects, if any.Method: A total of 200 pediatric patients of American Society of Anesthesiologists (ASA) grades I and II between one and 14 years of age of either sex posted for elective surgery were included in the study. After randomization, group R (n = 100) received 1.2 mg/kg rocuronium, and group S (n = 100) received 2 mg/kg succinylcholine intravenously. After confirming the mask ventilation, the study drugs were administered, and intubating conditions were assessed as excellent, good, poor, or impossible. Hemodynamic changes post-intubation were recorded as our secondary outcome.Result: Intubating conditions were excellent( 65%), good( 25%) and fair (10%) in patients of group R, while results in group S were excellent( 60%), good( 20%), fair (15%), and poor (5%) (p = 0.010). The heart rate was significantly increased post-intubation in group S, while there was no significant increase in systolic or diastolic blood pressure in either group. Conclusion: At a dose of 1.2 mg/kg body weight, rocuronium was a better alternative to succinylcholine for providing rapid intubating conditions and stable hemodynamics without associated adverse effects.

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Comparison of equipotent doses of rocuronium and vecuronium

Cited by 7 publications

References 12 publications

Effect of rocuronium on the heart rate and arterial blood pressure during combined general anaesthesia

Effect of rocuronium on the heart rate and arterial blood pressure during combined general anaesthesia

A comparison of haemodynamic responses between clinical assessment-guided tracheal intubation and neuromuscular block monitoring-guided tracheal intubation: A prospective, randomised study

A Randomized Double-Blind Comparative Study of the Intubating Conditions and Hemodynamic Effects of Rocuronium and Succinylcholine in Pediatric Patients

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