Comparison of Epidermal/Dermal Damage Between the Long-Pulsed 1064 nm Nd:YAG and 755 nm Alexandrite Lasers Under Relatively High Fluence Conditions: Quantitative and Histological Assessments

Lee, Ju Hwan; Park, Sora; Jo, Jeong Ho; Park, Sung Yun; Seo, Young Kwon; Kim, Sung Min

doi:10.1089/pho.2013.3665

Cited by 12 publications

(7 citation statements)

References 29 publications

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“…The added effect of the 1064-nm Nd:YAG laser was that it allowed laser energy to penetrate deeper into the dermis, which has been shown to affect collagen regeneration and remodelling in deep dermis. 11 , 28 This mechanism was presumed to enhance eyelid elasticity, leading to greater meibum secretion. Moreover, during application of the 1064-nm Nd:YAG laser in our protocol, the skin temperature exceeded the range of 40–42°C.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness and Safety of Combined Application of Three Modes of 2940-nm Erbium:YAG and 1064-nm Neodymium:YAG Lasers in Treatment of Meibomian Gland Dysfunction

Kasetsuwan¹,

Uthaithammarat²,

Piyacomn³

et al. 2021

OPTH

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To study the effectiveness and safety of upper and lower eyelid treatment with combined application of three modes of 2940-nm erbium-doped yttrium aluminium garnet (Er:YAG) and 1064-nm neodymium-doped yttrium aluminium garnet (Nd:YAG) lasers in patients with baggy eyelids (formed by intraorbital fat herniation) who exhibited meibomian gland dysfunction (MGD). Patients and Methods: In this prospective cohort study, patients with baggy eyelid who exhibited MGD received combined laser treatment at baseline, as well as at the 4-, 8-, and 12-week follow-ups. The primary endpoint was meibum quality score at 16-and 24-week follow-ups; secondary endpoints were ocular surface index scores, tear film lipid layer thicknesses, tear break up times (TBUTs), Oxford scheme grades, and meibography grades at 16-and 24-week follow-ups. Adverse events, uncorrected visual acuities, best-corrected visual acuities, and intraocular pressures were also recorded. Results: Sixteen patients (four men and 12 women; mean age, 56.38 ± 8.64 years) were included. Meibum quality scores at the 16-week follow-up were significantly lower than scores at baseline (p=0.043) and at the 24-week follow-up (p=0.015). TBUT was significantly exacerbated at the 24-week follow-up, compared with baseline (p=0.001) and the 16week follow-up (p=0.006). There were no significant changes in other parameters. All adverse events were mild and resolved without additional treatment. Conclusion: Combined application of three modes of 2940-nm Er:YAG and 1064-nm Nd: YAG lasers on upper and lower eyelids significantly improved meibum quality in patients with MGD; it ameliorated symptoms and signs of dry eye disease at 4 weeks after completion of laser treatment.

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Section: Discussionmentioning

confidence: 99%

Effectiveness and Safety of Combined Application of Three Modes of 2940-nm Erbium:YAG and 1064-nm Neodymium:YAG Lasers in Treatment of Meibomian Gland Dysfunction

Kasetsuwan¹,

Uthaithammarat²,

Piyacomn³

et al. 2021

OPTH

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“…Near infrared 1064‐nm long pulsed Nd‐YAG laser ( Laser genesis ) produces gradual dermal heating through cumulative absorption by oxyhemoglobin in the dermal microvasculature (primary target) and water (secondary target) 2,10 . The absorption coefficient of melanin for 1064‐nm radiation is lower than for shorter wavelengths, hence its safety for use among skin of color patients 8,12 .…”

Section: Discussionmentioning

confidence: 99%

“…water (secondary target). 2,10 The absorption coefficient of melanin for 1064-nm radiation is lower than for shorter wavelengths, hence its safety for use among skin of color patients. 8,12 For this study, the treatment technique involved using the laser in non-contact mode and painting the beam over the target area, producing mild heating in the skin.…”

Section: Rf-treated Skin Show Increase In the Expression Of Messengermentioning

confidence: 99%

“…These are popular "lunchtime" procedures with minimal to no downtime, lower risk profiles and a more natural appearance. Pre-and post-treatment histology shows an ideal epidermal surface temperature of 40 C-48 C is ideal as this correlates with a dermal temperature of 70 C, which is required collagen denaturation, thereby inducing neocollagenesis [8][9][10]. By delivering enough photothermal damage to the upper dermis with minimal damage to the epidermis, a wound healing process is started under a protected intact epidermis achieving the needed neocollagenesis and remodeling 7.…”

mentioning

confidence: 99%

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Split‐face comparison of grid fractional radiofrequency vs 1064‐nm Nd‐YAG laser treatment of periorbital rhytides among Filipino patients

Milante

Doria-Ruiz

Beloso

et al. 2020

Dermatologic Therapy

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Despite multiple individual studies proving efficacy of grid fractional monopolar radiofrequency (Grid RF) and near-infrared irradiation 1064-nm long-pulsed neodymium:YAG laser (Laser Genesis), there is a lack of controlled comparative trials between these devices. This study aims to compare the efficacy and safety of Grid RF versus Laser Genesis in the treatment of periorbital rhytides. This is a randomized, singleblind, split-face, prospective study. Eight patients with moderate to severe periorbital rhytides were treated with either Grid RF or Laser Genesis on each side of the face. Photographic and live assessment with the Lemperle Wrinkle Assessment grading scale was compared after 2 months. Difference in scores between Grid RF vs Laser genesis groups after 2 months was not statistically significant (P = 0.244). Each group showed statistically significant improvement months post-procedure (P < .05). Immediate adverse effects and satisfaction scale were similar for both groups (P > .05). At 2 months follow-up, no adverse effects were seen. Grid monopolar radiofrequency (Grid RF) vs near-infrared radiation 1064 nm long-pulsed Nd-YAG laser (Laser Genesis) were equally efficacious, safe, and well-tolerated among patients in the treatment of periorbital wrinkles (P > .05).

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“…Therefore, excessive depth and energy can be avoided. This reduces the risk of scar formation while achieving satisfactory results at the same time [8,9]. Furthermore, it generally needs one to two times of treatment to treat VL compared with long‐pulse Nd:YAG laser.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Curative Effect of Alexandrite Laser in the Treatment of Venous Lake of Lips

et al. 2020

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Background and Objectives Laser is being widely used in clinical treatment nowadays, including 755 nm Alexandrite laser [1,2]. This study was conducted to examine the clinical outcome of long‐pulse 755 nm Alexandrite laser in the treatment of venous lake of the lip. Study Design/Materials and Methods Forty‐one patients (2015–2019) were reviewed. The clinical outcomes were assessed 1 month after the treatment. The efficacy of the treatment was classified into four categories: basic recovery (most optimal outcome), effective, improvement, and ineffective (least favorable outcome). Adverse reactions were also recorded. Results Thirty‐three (80.49%) patients achieved basic recovery and 8 (19.51%) were effective; 29 (70.73%) recovered after receiving one treatment, 3 (7.32%) recovered after receiving two treatments, and 1 (2.44%) recovered after three treatments. Conclusion Long‐pulse 755 nm Alexandrite laser is an effective treatment for the venous lake of the lip. Lasers Surg. Med. © 2020 Wiley Periodicals LLC

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Comparison of Epidermal/Dermal Damage Between the Long-Pulsed 1064 nm Nd:YAG and 755 nm Alexandrite Lasers Under Relatively High Fluence Conditions: Quantitative and Histological Assessments

Abstract: The ideal treatment conditions for skin rejuvenation were 8 mm diameter with 30 J/cm2 and 10 mm diameter with 26 J/cm2 for the 1064 nm laser, and 8 mm diameter with 36 J/cm2 and 10 mm diameter with 26 J/cm2 for the 755 nm laser.

Cited by 12 publications

References 29 publications

Effectiveness and Safety of Combined Application of Three Modes of 2940-nm Erbium:YAG and 1064-nm Neodymium:YAG Lasers in Treatment of Meibomian Gland Dysfunction

Effectiveness and Safety of Combined Application of Three Modes of 2940-nm Erbium:YAG and 1064-nm Neodymium:YAG Lasers in Treatment of Meibomian Gland Dysfunction

Split‐face comparison of grid fractional radiofrequency vs 1064‐nm Nd‐YAG laser treatment of periorbital rhytides among Filipino patients

Analysis of the Curative Effect of Alexandrite Laser in the Treatment of Venous Lake of Lips

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