Comparison of entorhinal cortex atrophy between early‐onset and late‐onset Alzheimer's disease using the VSRAD, a specific and sensitive voxel‐based morphometry

Shibuya, Yuzuru; Kawakatsu, Shinobu; Hayashi, Hiroshi; Kobayashi, Ryota; Suzuki, Akihito; Sato, Chikako; Otani, Koichi

doi:10.1002/gps.3834

Cited by 14 publications

(19 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The atrophy rates in the volumes of the bilateral EC and amygdala were also associated with the time of symptom onset (Soldan et al, 2015). Patients with mild to moderate AD had a thinner EC than those with MCI (Shibuya et al, 2013;Velayudhan et al, 2013). Thus, the thickness of EC can indicate the severity of the disease and predict the slope of the degree of decline observed in tests of memory performance.…”

Section: Relationship Between Ec Atrophy and The Severity Of Admentioning

confidence: 93%

“…Du et al (2004) also found that the atrophy rates in the EC and hippocampus in patients with mild AD were positively correlated with memory deficits at baseline that were measured by delayed list recall; this evidence is in line with the conclusion of Stoub et al (Du et al, 2004;Stoub et al, 2010). Shibuya et al found that patients with early-onset AD exhibited less atrophy in EC than those with late-onset AD, but there was no significant difference in memory impairment, which was Brought to you by | Bibliotheque de l'Universite Laval Authenticated Download Date | 10/9/15 6:28 AM measured by the Alzheimer's Disease Assessment Scale (ADAS) word recall subtests, between the two subtypes (Shibuya et al, 2013). There are several potential reasons for the two different conclusions discussed previously:…”

Section: Relationship Between Ec Atrophy and The Severity Of Admentioning

confidence: 94%

“…The voxel-based specific regional analysis system for AD (VSRAD) is a method that can automatically and objectively map a loss of gray matter on a voxel-by-voxel basis after anatomic standardization (Ashburner and Friston, 2000;Hirata et al, 2005;Shibuya et al, 2013). VSRAD targeting of EC has been developed and found to be a sensitive diagnostic tool for observing the early stages of AD (Hirata et al, 2005;Matsuda, 2007).…”

Section: Voxel-based Specific Regional Analysis System For Admentioning

confidence: 99%

“…Mild cognitive impairment (MCI), a transition state between normal aging and dementia, has been identified as a precursor to AD (Pennanen et al, 2004;Shibuya et al, 2013). The main symptoms of MCI include deficits in memory while maintaining normal overall cognition and daily functioning (Petersen et al, 2001), which makes the clinical diagnosis of MCI difficult and can lead to incorrect diagnoses (Mendez, 2006;Burggren et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Entorhinal cortex: a good biomarker of mild cognitive impairment and mild Alzheimer’s disease

Zhou

Zhang

Zhao

et al. 2015

Reviews in the Neurosciences

View full text Add to dashboard Cite

AbstractEntorhinal cortex (EC), thought to be the location of the earliest lesions in Alzheimer’s disease (AD), has been widely studied in recent years. With the irreversible pathological changes of AD, there is an urgent need to find biomarkers that can be used to predict the presence of the disease before it is clinically expressed. The aim of this review is to summarize and analyze recent findings that are relevant to the important role of EC in the diagnosis of mild cognitive impairment (MCI) and mild AD and to describe a range of neuroimaging techniques used to define the EC boundary. A comprehensive literature search for articles published up to May 2015 was performed. Our research highlights the finding that atrophy in EC reflects the early pathological changes of AD and can be a strong predictor of prodromal AD. The early changes in EC are a good imaging biomarker that can be used to discriminate individuals with MCI from normal control subjects. A larger degree of atrophy in EC predicts increased disease severity, and the right EC in patients with mild AD exhibited greater changes than the left side. In addition, the EC seems to have an obvious advantage over the hippocampus as a biomarker when predicting future conversion to AD in individuals with MCI, and it may be of help in following the course of disease progression. In this review, we also summarize the main differences observed between the hippocampus and the EC when differentiating diseases. These findings will hopefully provide an opportunity for the effective prevention and early treatment of AD.

show abstract

Section: Relationship Between Ec Atrophy and The Severity Of Admentioning

confidence: 93%

Section: Relationship Between Ec Atrophy and The Severity Of Admentioning

confidence: 94%

Section: Voxel-based Specific Regional Analysis System For Admentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Entorhinal cortex: a good biomarker of mild cognitive impairment and mild Alzheimer’s disease

Zhou

Zhang

Zhao

et al. 2015

Reviews in the Neurosciences

View full text Add to dashboard Cite

show abstract

“…Prediction of conversion from MCI to AD using initial neuroimaging studies is an important research topic (Matsuda, 2007b;Shibuya et al, 2013). SPECT imaging using N-isopropyl-p-[I-123] iodoamphetamine (I-123 IMP) and graph plot analysis is a simple and convenient way to measure and compare regional cerebral blood flow (rCBF) among patient groups and within the same group during follow-up.…”

Section: Neuroimaging Proceduresmentioning

confidence: 99%

Cognitive and brain reserve in conversion and reversion in patients with mild cognitive impairment over 12 months of follow-up

Osone

Arai

Hakamada

et al. 2016

Journal of Clinical and Experimental Neuropsychology

View full text Add to dashboard Cite

show abstract

Utility of a shortened Hasegawa Dementia Scale Revised questionnaire to rapidly screen and diagnose Alzheimer’s disease

et al. 2021

View full text Add to dashboard Cite

Aims The aim of this study was to analyze the sensitivity and specificity of a shortened Hasegawa Dementia Scale Revised (shortened HDS‐R) questionnaire and explore its utility for the rapid screening and diagnosis of Alzheimer’s disease (AD). Methods We included 113 patients over the age of 60 years who visited our hospital from June 2018 to January 2021 including 70 subjects with AD and 43 healthy subjects. AD was diagnosed in accordance with the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, and the standard HDS‐R questionnaire was used as a neuropsychological examination. The shortened HDS‐R questionnaire was composed of the first seven subdomains (1 to 7) of the HDS‐R questionnaire and excluded subdomains 8 and 9. Magnetic resonance imaging (MRI) was performed to calculate the degree of atrophy of the whole brain, hippocampus, and parahippocampal gyrus. Results The cumulative contribution ratio of subdomains 1 to 7 of the HDS‐R questionnaire was as high as 94%, indicating that the construct validity of the shortened HDS‐R was very good. The correlation coefficient of the total scores of the shortened HDS‐R and the HDS‐R was 0.96, indicating that the criterion‐related validity was also very good. Furthermore, the shortened HDS‐R was significantly negatively correlated with the degree of atrophy in the whole brain, hippocampus, and parahippocampal gyrus, indicating that its concurrent validity was very good in relation to imaging parameters. Cronbach’s α coefficient of the shortened HDS‐R was 0.76, and the correlation coefficient of the item‐total correlation analysis was between 0.68 and 0.76, indicating that this questionnaire has high internal consistency and reliability. The total shortened HDS‐R score of the normal group (17.0 ± 1.9) was significantly higher than that of the AD group (8.6 ± 3.8), demonstrating that the total shortened HDS‐R score can be used to identify healthy individuals and patients with AD. When the cutoff score was 14 of 15, the sensitivity was 92.9% and the specificity was 88.4%. The diagnostic ability of the shortened HDS‐R was 91.2%, which indicates that it is similar to the full HDS‐R questionnaire as an AD screening tool. Conclusion As a neuropsychological examination questionnaire for the screening and diagnosis of AD, the shortened HDS‐R had very high validity and reliability. Its sensitivity, specificity, and diagnostic ability were similar to those of the gold standard HDS‐R; therefore, it can be considered a concise and useful questionnaire for AD screening and diagnosis in the older population.

show abstract

Comparison of entorhinal cortex atrophy between early‐onset and late‐onset Alzheimer's disease using the VSRAD, a specific and sensitive voxel‐based morphometry

Abstract: The present study using the VSRAD suggests that early-onset AD shows less atrophy in the entorhinal cortex than late-onset AD.

Cited by 14 publications

References 33 publications

Entorhinal cortex: a good biomarker of mild cognitive impairment and mild Alzheimer’s disease

Entorhinal cortex: a good biomarker of mild cognitive impairment and mild Alzheimer’s disease

Cognitive and brain reserve in conversion and reversion in patients with mild cognitive impairment over 12 months of follow-up

Utility of a shortened Hasegawa Dementia Scale Revised questionnaire to rapidly screen and diagnose Alzheimer’s disease

Contact Info

Product

Resources

About