2013
DOI: 10.5455/2320-1770.ijrcog20130205
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Comparison of efficacy of labetalol and methyldopa in patients with pregnancy-induced hypertension

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Cited by 15 publications
(16 citation statements)
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“…The present study found the adverse effects to be less in the patients receiving labetalol, and the side effects were minor and did not necessitate stoppage of any drugs or change of medications 10,12 . No significant difference was seen in the two groups regarding gestational age at delivery, type of delivery (vaginal or caesarean section) and number of preterm babies.…”
Section: Graph 1: Comparison Of Sbp and Dbp In Group A (Labetalol) Anmentioning
confidence: 77%
See 1 more Smart Citation
“…The present study found the adverse effects to be less in the patients receiving labetalol, and the side effects were minor and did not necessitate stoppage of any drugs or change of medications 10,12 . No significant difference was seen in the two groups regarding gestational age at delivery, type of delivery (vaginal or caesarean section) and number of preterm babies.…”
Section: Graph 1: Comparison Of Sbp and Dbp In Group A (Labetalol) Anmentioning
confidence: 77%
“…11 In the present study no significant difference between the two groups was observed regarding requirement of dose escalation. Some researchers have reported such a difference, which was probably due to higher frequency of administration of labetalol 11,12 . In a study wherein pregnant women with both types of HT (mild as well as severe) was included, the mean doses of both the drugs to control BP were found to be higher 12 .…”
Section: Graph 1: Comparison Of Sbp and Dbp In Group A (Labetalol) Anmentioning
confidence: 99%
“…11 Subhedar et al, 2013, there was a more significant fall in MAP in labetalol group compared to methyldopa group and also time required to control BP was 36.97 hrs in labetalol group and time taken to control BP was 42.22hrs in methyldopa group. 12 Lamming et al, there was a highly significant fall in MAP in the group treated with labetalol (p<0.001) but no significant fall was noted in the group tested with methyldopa (p value>0.05). 13 Similar response rates have been found in few more studies like-lardoux's group 82%, Michael 92%.…”
Section: Discussionmentioning
confidence: 95%
“…Adverse effects profile was similar to study conducted by Subhedar V et al and ElQarmalawi et al (Table 3). 18,26 Our study reported the effectiveness of methyldopa and nifedipine among 95 patients with moderate gestational hypertension with a follow up of four weeks. Nifedipine having an additional tocolytic action showed significant reduction of systolic blood pressure at one month compared to methyldopa.…”
Section: Discussionmentioning
confidence: 99%
“…14 Marked fall of both systolic and diastolic pressure generally between 24 and 48 hours from the start of using methyldopa was noticed by S. F. Hans et al 17 Subhedar V et al showed that treatment of hypertension in pregnancy with methyldopa will reduce Mean Arterial Pressure. 18 Nifedipine a type 2 calcium channel blocker inhibits the inward flow of calcium across the L-type slow channels of cellular membranes and used as antihypertensive treatment in pregnancy since years, proved its efficacy in treatment of high blood pressure along with safety to mother and fetus. 19 Nifedipine has been shown to cause relaxation of the uterine smooth muscle and hence its use as a tocolytic agent.…”
mentioning
confidence: 99%