Comparison of effects of quinapril and metoprolol on glycaemic control, serum lipids, blood pressure, albuminuria and quality of life in non‐insulin‐dependent diabetes mellitus patients with hypertension

Östman, Jan; Asplund, Kjell; T, Bystedt; Dahlof, Bjoern; Jern, Sverker; Kjellström, Thomas; Lithell, Hans

doi:10.1046/j.1365-2796.1998.00319.x

Cited by 14 publications

(8 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With only a handful of studies on effects of antihypertensive treatment on HRQOL in the diabetic population, our understanding of the treatment choice is limited. While Ostman and colleagues found no significant differences in the overall well-being and symptom scores with either metoprolol or quinapril,(62) McGill and colleagues demonstrated that carvedilol was superior to metoprolol in terms of the perceived burden of DM-related symptoms. (63) This was attributed to the differences in the pharmacological profiles of the 2 drugs.…”

Section: Health-related Quality Of Life In Hypertension With Dmmentioning

confidence: 97%

Health-Related Quality of Life in Hypertension, Chronic Kidney Disease, and Coexistent Chronic Health Conditions

Soni

Porter

Lash

et al. 2010

Advances in Chronic Kidney Disease

View full text Add to dashboard Cite

With the increasing prevalence of hypertension, there has been a growing interest in understanding the health-related quality of life (HRQOL) of patients with hypertension. Although hypertension is often perceived as asymptomatic, it is associated with impaired HRQOL due to complications or co-morbidities, awareness of the diagnosis and adverse effects from anti-hypertensive medications. This article focuses on the literature published since 2000, on HRQOL in elderly hypertensive individuals as well as hypertensives with co-existent diseases, including chronic kidney disease (CKD), cardiovascular disease and diabetes mellitus. Most of the studies found that hypertensive individuals with co-existent co-morbidities tend to have lower HRQOL than those with hypertension alone, and identified the number of co-morbid illnesses as an independent determinant of HRQOL. The most pronounced effect was noted in the physical function domains of HRQOL. Studies have also examined the effects on HRQOL of specific classes of antihypertensive drugs without specific demonstration of superiority of 1 drug class over another in terms of HRQOL measures. While there is evidence in favor of ACE-inhibition for improving renal and cardiovascular outcomes in hypertensive patients, its role in ameliorating HRQOL outcomes remains to be established.

show abstract

Section: Health-related Quality Of Life In Hypertension With Dmmentioning

confidence: 97%

Health-Related Quality of Life in Hypertension, Chronic Kidney Disease, and Coexistent Chronic Health Conditions

Soni

Porter

Lash

et al. 2010

Advances in Chronic Kidney Disease

View full text Add to dashboard Cite

show abstract

“…A recent study by Kaiser et al had shown no significant difference in total body insulin sensitivity during treatment with enalapril and nebivolol [47]. Structural and functional normalization of the alterations in the resistance arteries found in patients with essential hypertension has been demonstrated after long‐term treatment with ACE inhibitors [48].…”

Section: Discussionmentioning

confidence: 99%

Haemorheological disturbances in hypertensive type 2 diabetic patients – influence of antihypertensive therapy

Kearney‐Schwartz

Virion

Stoltz

et al. 2007

Fundamemntal Clinical Pharma

View full text Add to dashboard Cite

Haemorheological changes have been described in hypertension as well as in diabetes mellitus. Antihypertensive treatment improves rheology in hypertensive patients. The aim of this study was to describe the haemorheological profile and its impact on shear stress in hypertensive type 2 diabetes mellitus patients (HT + DM) and to investigate the effect of antihypertensive therapy on blood rheology using a double-blind randomized protocol, comparing the calcium antagonist amlodipine with the angiotensin-converting enzyme (ACE) inhibitor enalapril. A total of 144 patients with hypertension and type 2 diabetes (64 of transversal study and 80 of randomized clinical trial) were compared with 92 controls belonging to a transversal study. Secondarily, in a separate analysis, therapeutic effects of calcium antagonist amlodipine and ACE inhibitor enalapril were compared in a longitudinal, randomized trial in the patients. We assessed whole-blood viscosity, plasma viscosity, partial and total disaggregation times, haematocrit and fibrinogen. Radial artery systolic flow velocity was measured by pulsed Doppler. Shear stress was calculated as the product of flow velocity x whole-blood viscosity. Compared with controls, patients had significantly higher whole-blood viscosity for all shear rates (P < 0.001) as well as higher arterial diameter and systolic blood flow velocity (2.8 +/- 0.3 vs. 2.6 +/- 0.3 mm, P < 0.001; and 50.8 +/- 11.6 vs. 45.6 +/- 9.8 cm/s, P = 0.01, respectively). Whole-blood viscosity at shear rate gamma = 128/s tended to increase with amlodipine (+1.13%) and decrease with enalapril (-2.47%) (P = 0.028 for inter-group difference). In hypertensive diabetic patients, hyperviscosity contributes to increased shear stress. Haemorheological disturbances in these patients are not significantly influenced by blood pressure lowering with antihypertensive therapy by ACE inhibitor enalapril or calcium antagonist amlodipine. Other factors potentially contributing to rheology and arterial changes may be more critical in HT + DM patients and need further investigation.

show abstract

“…Ein Anstieg der Lebensqualität konnte in der Mehrzahl der Studien für ACE-Hemmer und nur vereinzelt für Betablocker, Diuretika und Calciumantagonisten gefunden werden [1, 9,10,23,28,29,32,39]. Kontrollierte Studien mit älteren Patienten konnten bislang nur für die Substanzen Captopril, Losartan und Telsartan einen Anstieg der Lebensqualität unter Therapie zeigen [6,9,21].…”

Section: Nicht Medikamentöse Einflussfaktorenunclassified

“…Vor diesem Hintergrund weisen unsere Ergebnisse auf einen mögli-chen Vorteil von Quinapril bei antihypertensiv zu behandelnden geriatrischen Patienten. In einer kontrollierten Studie bei Patienten mit Hypertonie und nicht insulinabhän-gigem Diabetes mellitus war Quinapril ebenfalls einer Vergleichssubstanz (Metoprolol) bezüglich der Lebensqualität überlegen [32]. Mehrere Einschränkungen sind bei der Ergebnisinterpretation zu beachten.…”

Section: Nicht Medikamentöse Einflussfaktorenunclassified

“…Nachfolgende Vergleichsstudien zur Lebensqualität unter antihypertensiver Therapie wurden bislang meist mit neu eingeführten Substanzen, nicht jedoch wieder mit Captopril durchgeführt [23,28,29,31,32,35,41,44]. Neuere vergleichende Arbeiten zur Lebensqualität speziell bei geriatrischen Patienten erfolgten mit Betablockern, Calciumantagonisten, AT-1-Rezeptorantagonisten und Enalapril und konnten hier keine signifikante Überlegenheit einer antihypertensiven Einzelsubstanz nachweisen [7,9,21,27].…”

Section: Introductionunclassified

See 1 more Smart Citation

Lebensqualität und psychosoziale Faktoren unter antihypertensiver Therapie Ein Vergleich von Captopril und Quinapril bei geriatrischen Patienten

Michalsen

Wenzel²,

Mayer

et al. 2001

Herz

View full text Add to dashboard Cite

show abstract

Comparison of effects of quinapril and metoprolol on glycaemic control, serum lipids, blood pressure, albuminuria and quality of life in non‐insulin‐dependent diabetes mellitus patients with hypertension

Cited by 14 publications

References 54 publications

Health-Related Quality of Life in Hypertension, Chronic Kidney Disease, and Coexistent Chronic Health Conditions

Health-Related Quality of Life in Hypertension, Chronic Kidney Disease, and Coexistent Chronic Health Conditions

Haemorheological disturbances in hypertensive type 2 diabetic patients – influence of antihypertensive therapy

Lebensqualität und psychosoziale Faktoren unter antihypertensiver Therapie Ein Vergleich von Captopril und Quinapril bei geriatrischen Patienten

Contact Info

Product

Resources

About