Lebensqualität und psychosoziale Faktoren unter antihypertensiver Therapie Ein Vergleich von Captopril und Quinapril bei geriatrischen Patienten

Michalsen, Andreas; Wenzel, René R.; Mayer, Christina; Broer, Matthias; Philipp, Thomas; Dobos, Gustav

doi:10.1007/pl00002050

Cited by 8 publications

(2 citation statements)

References 29 publications

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“…In these studies, depression, and certain demographic- and disease-related characteristics (e.g., older age, female gender, HTN medication, comorbidity) were associated with poor HRQOL (Heyworth, Hazell, Linehan, & Frank, 2009; Holt et al, 2010; Michalsen et al, 2001; Rueda & Pérez-García, 2006; Ucan & Ovayolu, 2010). In particular, depression has been a consistent risk factor for poor HRQOL in patients with HTN (Heyworth et al, 2009; Holt et al, 2010; Michalsen et al, 2001; Rueda & Pérez-García, 2006; Ucan & Ovayolu, 2010). Few studies indicate that social support may play a protective role in promoting HRQOL in the presence of depressive symptoms.…”

Section: Introductionmentioning

confidence: 99%

“…Likewise, Huang et al (2010) presented that higher social support was significantly less likely to improve depression than those without social support among chronic heart disease patients. One study suggested social support as a possible modifiable risk factor for HRQOL among elderly with HTN (Michalsen et al, 2001). While these studies offer some insights as to potential contributors to HRQOL among elderly, to the best of our knowledge, no previous study looked specifically at potential contributors to HRQOL among Asian immigrant elders with HTN.…”

Section: Introductionmentioning

confidence: 99%

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Correlates of Health-Related Quality of Life Among Korean Immigrant Elders

2013

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Health-related quality of life (HRQOL) is a key clinical outcome, particularly for individuals with chronic conditions such as hypertension (HTN). While no previous research has examined contributors to HRQOL among Asian Americans in the United States, this study was conducted to identify correlates of HRQOL in hypertensive Korean immigrant elders (≥ 60 years of age) to address the gap. A total of 440 Korean elders with HTN participated in the study. The hierarchical regression model for HRQOL explained 32.8% of the variance. Female gender (β = .109, p = .036), a greater number of comorbid conditions (β = .183, p = .000), lower social support (β = −.240, p = .000), and greater depressive symptoms (β = .402, p = .000) were associated with poorer HRQOL. Depression was the most potent correlate of HRQOL among elderly Korean Americans (KA) with HTN. Future intervention should consider managing depression as an essential component of comprehensive HTN care for this minority population.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlates of Health-Related Quality of Life Among Korean Immigrant Elders

2013

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Angiotensin I‐converting enzyme I/D polymorphism and suicidal behaviors

Sparks¹,

Hunsaker

Amouyel

et al. 2008

American J of Med Genetics Pt B

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Suicide is one of the ten most common causes of death in Western countries. It involves genetic vulnerability factors and is often associated with major depression. A Japanese team reported an association between the insertion allele of the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with completed suicide. The ACE I/D polymorphism was investigated in two independent case-control studies, one involving 64 suicide completers and 90 controls who all underwent forensic investigations, the second one consisting of 588 suicide attempters and 639 controls. In the two population samples studied a statistically significant risk of suicidal behavior was observed for subjects bearing the DD genotype. These results suggest a possible role of the renin-angiotensin system in suicidal behavior.

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