Comparison of effects of preoperatively administered lornoxicam and tenoxicam on morphine consumption after laparoscopic cholecystectomy

Abstract

Preoperatively administered lornoxicam 16 mg significantly prolonged the first morphine demand time, reduced postoperative morphine consumption during the first 4 h and caused significantly fewer adverse effects when compared with tenoxicam after laparoscopic cholecystectomy.

The efficacy of adding dexketoprofen trometamol to tramadol with patient controlled analgesia technique in post-laparoscopic cholecystectomy pain treatment

“…[1] Nonsteroid antiinflammatory drugs (NSAIDs) are often utilized in postoperative analgesia because they have analgesic effects comparable to opioids but lack the adverse effects of opioids. NSAIDs are a wide group of agents which have analgesic, antipyretic and antiinflammatory properties.…”

The effect of analgesic education on pain in patients undergoing breast surgery: within 24 hours after the operation

“…(1996) reported that lornoxicam (Xefo flk 8 mg) was more effective for acute pain and inflammation, such as Tramadol. Kocaayan et al. (2007) reported that lornoxicam significantly reduced morphine use in patients after laparoscopic cholecystectomy compared with tenoxicam.…”

“…It has been reported to provide effective analgesia for surgical pain owing to this property (Staunstrup et al. 1999, Kocaayan et al. 2007, Ekinci & Beydemir 2009).…”

Preoperative lornoxicam for pain prevention after tonsillectomy in adults

“…It exerts its analgesic effect not only via inhibition of cyclooxygenase (COX) I and II, but also by leading to a release of endogenous dynorphin and beta-endorphin [13]. It has a better tolerability profile and longer duration of effect than other NSAIDs [10,14]. Due to these properties and its availability as a parenteral form, lornoxicam may be favorable for acute perioperative pain management, particularly in patients for whom perioperative oral administration is undesirable [15].…”

“…Due to these properties and its availability as a parenteral form, lornoxicam may be favorable for acute perioperative pain management, particularly in patients for whom perioperative oral administration is undesirable [15]. The selected dose of IV lornoxicam (16 mg) was based on several previous studies [14,[16][17][18], while other clinical trials found that a preoperative dose of 8 mg was efficient for postoperative analgesia [6][7][8][9][10][11]. Although the lower dose provided effective pain relief, lornoxicam 16 mg may produce more potent analgesia and of longer duration [14,17,18].…”