Comparison of effects of LLLT and LIPUS on fracture healing in animal models and patients: A systematic review

Bayat, Mohammad; Virdi, Amarjit S.; Jalalifirouzkouhi, Reza; Rezaei, Fatemehalsadat

doi:10.1016/j.pbiomolbio.2017.07.004

Cited by 30 publications

(23 citation statements)

References 156 publications

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“…The PBMT protocol used in the present experiment is due to previous studies (in vivo) on tissue regeneration [8,12,13,16], plus a literature review on the action of PBMT specifically on bone tissue, in which the length of 830 nm was cited as the most used (40.79%) and with positive effects in 98.68% [67]; in another review, satisfactory results were observed between the PBMT and xenograft in 17 of the 18 articles included [23]. The literature points to laser-modulated bone formation with increased bone growth factors in differentiated cells by stimulating matrix secretion, cell proliferation and reduced inflammation [65,68].…”

Section: Discussionmentioning

confidence: 99%

“…PBMT has been shown to be an ally in the process of bone reconstruction; however, the consensus about parameters for the purpose of bone regeneration is still uncertain in the literature, since studies show varieties of protocols, thus obtaining different results [23,74,75] such as differentiation, density and osteogenic proliferation [67,74,76].…”

Section: Discussionmentioning

confidence: 99%

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Photobiomodulation Therapy Associated with Heterologous Fibrin Biopolymer and Bovine Bone Matrix Helps to Reconstruct Long Bones

et al. 2020

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Bone defects cause aesthetic and functional changes that affect the social, economic and especially the emotional life of human beings. This complication stimulates the scientific community to investigate strategies aimed at improving bone reconstruction processes using complementary therapies. Photobiomodulation therapy (PBMT) and the use of new biomaterials, including heterologous fibrin biopolymer (HFB), are included in this challenge. The objective of the present study was to evaluate the influence of photobiomodulation therapy on bone tibial reconstruction of rats with biomaterial consisting of lyophilized bovine bone matrix (BM) associated or not with heterologous fibrin biopolymer. Thirty male rats were randomly separated into three groups of 10 animals. In all animals, after the anesthetic procedure, a noncritical tibial defect of 2 mm was performed. The groups received the following treatments: Group 1: BM + PBMT, Group 2: BM + HFB and Group 3: BM + HFB + PBMT. The animals from Groups 1 and 3 were submitted to PBMT in the immediate postoperative period and every 48 h until the day of euthanasia that occurred at 14 and 42 days. Analyses by computed microtomography (µCT) and histomorphometry showed statistical difference in the percentage of bone formation between Groups 3 (BM + HB + PBMT) and 2 (BM + HFB) (26.4% ± 1.03% and 20.0% ± 1.87%, respectively) at 14 days and at 42 days (38.2% ± 1.59% and 31.6% ± 1.33%, respectively), and at 42 days there was presence of bone with mature characteristics and organized connective tissue. The µCT demonstrated BM particles filling the defect and the deposition of new bone in the superficial region, especially in the ruptured cortical. It was concluded that the association of PBMT with HFB and BM has the potential to assist in the process of reconstructing bone defects in the tibia of rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Photobiomodulation Therapy Associated with Heterologous Fibrin Biopolymer and Bovine Bone Matrix Helps to Reconstruct Long Bones

et al. 2020

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“…Laser stimulation is widely used for medical applications because of its electromagnetic radiation nature that, not belonging to the X‐ray family, is not expected to induce iatrogenic malignancies development . The key hallmarks of laser light are represented by monochromaticity (it is composed of only one color or wavelenght), coherence (all light waves are spatially and temporally in phase) and collimation (all light rays are parallel and do not significantly diverge one from the other even over long distances).…”

Section: Lasers In Medicinementioning

confidence: 99%

Near infrared low‐level laser therapy and cell proliferation: The emerging role of redox sensitive signal transduction pathways

Migliario

Sabbatini

Mortellaro

et al. 2018

Journal of Biophotonics

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Lasers devices are widely used in various medical fields (eg, surgery, dermatology, dentistry, rehabilitative medicine, etc.) for different applications, ranging from surgical ablation of tissues to biostimulation and pain relief. Laser is an electromagnetic radiation, which effects on biological tissues strongly depends on a number of physical parameters. Laser wavelength, energy output, irradiation time and modality, temperature and tissue penetration properties have to be set up according to the clinical target tissue and the desired effect. A less than optimal operational settings, in fact, could result in a null or even lethal effect. According to the first law of photobiology, light absorption requires the presence of a specific photoacceptor that after excitation could induce the activation of downstream signaling pathways. Low-level lasers operating in the red/near infrared portion of the light spectra are generally used for biostimulation purposes, a particular therapeutic application based on the radiant energy ability to induce nonthermal responses in living cells. Biostimulation process generally promotes cell survival and proliferation. Emerging evidences support a low-level laser stimulation mediated increase in "good" reactive oxygen species, able to activate redox sensitive signal transduction pathways such as Nrf-2, NF-kB, ERK which act as key redox checkpoints.

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“…In case of very wide defects, in which the vascularization capacity is impaired or there is mechanical instability, the ability to recover the structure and function is limited. Therefore, several techniques and materials have been investigated to accelerate bone repair, and low-level laser has been a therapeutic option often indicated for that purpose 2 − 4 , 6 , 17 , 20 , 25 . Nonetheless, there are controversies as to its applicability, since the success of this therapy depends not only on the dose, but also on the time and irradiation mode 3 , 5 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo study

et al. 2018

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The repair of bone defects raises the interest of investigators in several health specialties. Grafting techniques with bone substitutes and laser therapies have been investigated to replace autogenous bone and accelerate the bone healing process.ObjectiveTo evaluate the effect of photobiomodulation therapy (PBMT) associated with guided bone regeneration (GBR) in critical size defects.Material and MethodsThe study was conducted on 80 male rats (Rattus norvegicus albinus, Wistar) submitted to surgical creation of a critical size defect on the calvaria, divided into eight study groups: group C (control - only blood clot); group M (collagen membrane); group PBMT (photobiomodulation therapy); group AB (autogenous bone); group AB+PBMT; group AB+M; group PBMT+M; group AB+PBMT+M. The animals were killed 30 days postoperatively. After tissue processing, bone regeneration was evaluated by histomorphometric analysis and statistical analyses were performed (Tukey test, p<0.05).ResultsAll groups had greater area of newly formed bone compared to group C (9.96±4.49%). The group PBMT+M (achieved the greater quantity of new bone (64.09±7.62%), followed by groups PBMT (47.67±8.66%), M (47.43±15.73%), AB+PBMT (39.15±16.72%) and AB+PBMT+M (35.82±7.68%). After group C, the groups AB (25.10±16.59%) and AB+M (22.72±13.83%) had the smallest quantities of newly formed bone. The area of remaining particles did not have statistically significant difference between groups AB+M (14.93±8.92%) and AB+PBMT+M (14.76±6.58%).ConclusionThe PBMT utilization may be effective for bone repair, when associated with bone regeneration techniques.

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Comparison of effects of LLLT and LIPUS on fracture healing in animal models and patients: A systematic review

Cited by 30 publications

References 156 publications

Photobiomodulation Therapy Associated with Heterologous Fibrin Biopolymer and Bovine Bone Matrix Helps to Reconstruct Long Bones

Photobiomodulation Therapy Associated with Heterologous Fibrin Biopolymer and Bovine Bone Matrix Helps to Reconstruct Long Bones

Near infrared low‐level laser therapy and cell proliferation: The emerging role of redox sensitive signal transduction pathways

Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo study

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