Comparison of Effect of Aloe vera Gel and Nystatin on Candida Species: An In Vitro Study

Rezvaninejad, Rayehehossadat; Rezvaninejad, Razieh Sadat; Ashoorian, Mohammad Javad; Talebi, Maryam

doi:10.5812/jjhs-122029

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…The ethanolic extract of Aloe vera leaves shows antimicrobial properties against different strains of bacteria and pathogenic fungal strains [52], and Aloe vera gel has been effective against oral candidiasis. However, the efficacy of this gel was poor in comparison to nystatin, so the inhibitory concentrations of extracts should be higher than 100 mg/mL [53].…”

Section: Natural Products: Potential Adjuvants Of Antifungal Chemothe...mentioning

confidence: 99%

“…Knowing the density of these oils would be necessary for comparison with other data, due to the different units reported in the referred cumin study. On the other hand, maqui berry, rosemary, and aloe vera extracts show low antifungal activity, since the concentrations required for obtaining a noticeable effect are more than 1000 times higher, around >10 mg/mL, 50-200 mg/mL, and around 625 µL/mL, respectively [53,74,81,82]. These NPs should be considered as adjuvants for accompanying other antifungal agents rather than as true alternative options for exclusive treatment.…”

Section: Concluding Remarks and Perspectivesmentioning

confidence: 99%

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Natural Substances as Valuable Alternative for Improving Conventional Antifungal Chemotherapy: Lights and Shadows

Argüelles,

Sánchez-Fresneda,

Argüelles

et al. 2024

JoF

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Fungi are eukaryotic organisms with relatively few pathogenic members dangerous for humans, usually acting as opportunistic infections. In the last decades, several life-threatening fungal infections have risen mostly associated with the worldwide extension of chronic diseases and immunosuppression. The available antifungal therapies cannot combat this challenge because the arsenal of compounds is scarce and displays low selective action, significant adverse effects, and increasing resistance. A growing isolation of outbreaks triggered by fungal species formerly considered innocuous is being recorded. From ancient times, natural substances harvested from plants have been applied to folk medicine and some of them recently emerged as promising antifungals. The most used are briefly revised herein. Combinations of chemotherapeutic drugs with natural products to obtain more efficient and gentle treatments are also revised. Nevertheless, considerable research work is still necessary before their clinical use can be generally accepted. Many natural products have a highly complex chemical composition, with the active principles still partially unknown. Here, we survey the field underlying lights and shadows of both groups. More studies involving clinical strains are necessary, but we illustrate this matter by discussing the potential clinical applications of combined carnosic acid plus propolis formulations.

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Section: Natural Products: Potential Adjuvants Of Antifungal Chemothe...mentioning

confidence: 99%

Section: Concluding Remarks and Perspectivesmentioning

confidence: 99%

Natural Substances as Valuable Alternative for Improving Conventional Antifungal Chemotherapy: Lights and Shadows

Argüelles,

Sánchez-Fresneda,

Argüelles

et al. 2024

JoF

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Aloe vera―An Extensive Review Focused on Recent Studies

Catalano,

Ceramella,

Iacopetta

et al. 2024

Foods

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Since ancient times, Aloe vera L. (AV) has attracted scientific interest because of its multiple cosmetic and medicinal properties, attributable to compounds present in leaves and other parts of the plant. The collected literature data show that AV and its products have a beneficial influence on human health, both by topical and oral use, as juice or an extract. Several scientific studies demonstrated the numerous biological activities of AV, including, for instance, antiviral, antimicrobial, antitumor, and antifungal. Moreover, its important antidepressant activity in relation to several diseases, including skin disorders (psoriasis, acne, and so on) and prediabetes, is a growing field of research. This comprehensive review intends to present the most significant and recent studies regarding the plethora of AV’s biological activities and an in-depth analysis exploring the component/s responsible for them. Moreover, its morphology and chemical composition are described, along with some studies regarding the single components of AV available in commerce. Finally, valorization studies and a discussion about the metabolism and toxicological aspects of this “Wonder Plant” are reported.

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Antibacterial effects of aqueous and alcoholic extracts of Zataria multiflora in comparison with chlorhexidine mouthwash on some pathogenic oral streptococci: An in vitro study

Rezvaninejad

Noveiri

Rezvaninejad

et al. 2023

Dental Research Journal

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Background: Increasing antibiotic resistance to pathogenic microorganisms (Streptococci) has led scientists around the world to turn to medicinal plants. In this study, the effects of aqueous and alcoholic extracts of Zataria multiflora on the in vitro growth of Streptococcus mutans and Streptococcus sanguis have been considered and compared with 0.2% chlorhexidine mouthwash. Materials and Methods: In this in vitro study, the inhibitory growth zone was accessed by the disc diffusion method after 48 h of incubation at 37 C. To find out the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of treatments, colony counts of cultured bacteria on nutrient agar have been considered at serial dilution at 1/2-1/1024 dilution rates. An independent t-test was used to compare the antibacterial effects of extracts while the level of significance of was considered to be 5% (P < 0.05). Results: The inhibitory growth zones of aqueous and alcoholic extracts on S. mutans were 26.8 mm and 35.8 mm, respectively, whereas growth zones for S. sanguis were considered as 25.8 mm and 33.2 mm, sequentially. Comparisons showed better effects of alcohol compared to aqueous extract (P > 0.05). The MIC and MBC assessments showed the same results (P > 0.05). In all comparisons, the effects of 0.2% chlorhexidine mouthwash were significantly better than both Z. multiflora aqueous and alcoholic extracts (P > 0.05). Conclusion: The different solvents may have contributed to the better effects of an alcoholic to aqueous extract of Z. multiflora on the growth of both bacteria. These two extracts could be used for early inhibition of the growth of the planktonic phase, as well as for better oral taste after chlorhexidine applications.

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Comparison of Effect of Aloe vera Gel and Nystatin on Candida Species: An In Vitro Study

Cited by 3 publications

References 10 publications

Natural Substances as Valuable Alternative for Improving Conventional Antifungal Chemotherapy: Lights and Shadows

Natural Substances as Valuable Alternative for Improving Conventional Antifungal Chemotherapy: Lights and Shadows

Aloe vera―An Extensive Review Focused on Recent Studies

Antibacterial effects of aqueous and alcoholic extracts of Zataria multiflora in comparison with chlorhexidine mouthwash on some pathogenic oral streptococci: An in vitro study

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