Comparison of drug release behavior of bacterial cellulose loaded with ibuprofen and propranolol hydrochloride

Abstract

The aim of this study was to investigate the drug release behavior from bacterial cellulose (BC).

Bacterial cellulose nanoparticles as a sustainable drug delivery platform for protein-based therapeutics

“…56,57 A recent study loaded a BC film with ibuprofen, a low solubility drug, and propranolol hydrochloride, a highly soluble drug. 21 Both drugs showed immediate release with freeze-dried and air-dried BC film preparations, yet the freeze-drying method showed a sustained release for soluble drugs while air drying was optimal for DL at low drug concentrations. 21 Another study used a top-down approach to mill a BC film into microparticles to drug load cloxacillin and cefuroxime sodium salts, adequate model drugs for antimicrobial activity in wound healing and facial scrubs.…”

“…21 Both drugs showed immediate release with freeze-dried and air-dried BC film preparations, yet the freeze-drying method showed a sustained release for soluble drugs while air drying was optimal for DL at low drug concentrations. 21 Another study used a top-down approach to mill a BC film into microparticles to drug load cloxacillin and cefuroxime sodium salts, adequate model drugs for antimicrobial activity in wound healing and facial scrubs. 22 All methods showed an immediate drug release of approximately 85% in the initial 30 min while demonstrating good antibacterial activity.…”

“…16 To date, BC has primarily been used in the drug delivery field for transdermal applications, where BC films are prepared for use in antimicrobial wound healing and dressing, and face and eye masks for anti-aging and scarred skin rejuvenation. [20][21][22] Spherical BC particles with diameters in the 0.5-1.0 mm range have also previously been reported to enable a controlled drug release and exhibit antibacterial properties for tissue engineering and drug delivery applications. 8,16,[22][23][24][25] Despite the drug delivery potential demonstrated by BC microparticles, their application for long-circulation times and deep tissue penetration is limited due to their size.…”

An Evaluation of the Usability of Argon Plasma-Treated Bacterial Cellulose as a Carrier for Controlled Releases of Glycoside Hydrolases PelAh and PslGh, Which Are Able to Eradicate Biofilm

“…Moreover, the PelA h release mechanism also fit the Higuchi and Korsmayer-Peppas models, with a correlation coefficient of R 2 > 0.9. The value of exponent n for the PelA h release was >0.5 and followed non-Fickan diffusion [54,55].…”

Controllable Drug-Release Ratio and Rate of Doxorubicin-Loaded Natural Composite Films Based on Polysaccharides: Evaluation of Transdermal Permeability Potential

“…In contrast, releasing the drug in a film state maintains the form and enables controlled release by adjusting compound ratios, temperature, and reaction time . The incorporation of montmorillonite (MMT), a mineral with remarkable adsorption capabilities, into natural polysaccharide-based drug delivery systems is explored. − MMT’s ability to provide continuous drug release at a controlled concentration makes it promising for enhancing drug delivery. Studies on starch/MMT and chitosan/MMT composite films have demonstrated controlled release patterns influenced by the MMT content.…”