Comparison of Drug-Related Problems in Different Patient Groups

Viktil, Kirsten K.; Blix, Hege Salvesen; Reikvam, Aasmund; Moger, Tron Anders; Hjemaas, Bodil Jahren; Walseth, E; Vraalsen, Tine F; Pretsch, Piia; Jørgensen, F

doi:10.1345/aph.1d531

Cited by 36 publications

(39 citation statements)

References 23 publications

(27 reference statements)

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“…Of potential risk factors for DRPs (see Methods) polypharmacy ( ‡5 drugs) occurred most commonly (47.4% of the patients), followed by the use of drugs with a narrow therapeutic index (29.1%), reduced renal function (18.9%), cardiac failure (18.1%), previous allergy or adverse events to drugs (15.2%), diabetes mellitus (11.3%) and others (15.4%). The drug groups causing most problems were antitrombotic agents, NSAIDs and opioids; details have been reported elsewhere [1,2].…”

Section: Resultsmentioning

confidence: 99%

“…Drug therapy is growing more complex, thus making appropriate drug prescribing increasingly challenging. In a previous study we found one or more DRPs in about four fifth of the patients in general hospitals and also identified risk factors for DRPs [1,2]. A multidisciplinary approach, including clinical pharmacists addressing DRPs, has been shown to reduce the frequency of DRPs [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of drug-related problems discussed by hospital pharmacists in multidisciplinary teams

et al. 2006

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The majority of patients had one or more DRPs. The problems identified as DRPs by the pharmacists were accepted as such by the physicians and to a high degree acted upon. Both clinical significance of the DRP and patient characteristics influenced physician immediate acceptance rate. Some DRPs could be solved by direct contact with nurses or the patients. Awareness of DRPs increases through participation of pharmacists in the multidisciplinary therapeutic hospital team.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characteristics of drug-related problems discussed by hospital pharmacists in multidisciplinary teams

et al. 2006

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“…During the last 20 years clinical pharmacist became a unique and efficient member of the healthcare team and contributed substantially to the wellbeing of patients in the different health care settings [10][11][12][13][14][15][16][17][18][19][20][30][31][32][33]. Despite this, clinical pharmacy is very slowly progressing in the developing countries.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence and nature of DRPs have been investigated previously in inpatients, outpatients and other clinical settings [10][11][12][13][14][15][16][17][18][19][20]. However, many of these studies had methodological problems related to their design, retrospective nature, definition of DRPs or to the lack of appropriate assessment of patients data.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive assessment of treatment related problems in hospitalized medicine patients in Jordan

et al. 2011

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We have found that prevalence of TRPs is substantially high among patients hospitalized at the internal medicine department. TRPs related to Dosage regimens, untreated conditions, patient monitoring, drug interactions, and drug choices were the most common. Most of TRPs identified by pharmacists were clinically significant. Pharmacists' interventions contributed substantially to the resolving of many of the identified TRPs. Patients suffering from higher number of medical conditions and receiving higher number of medications should be given the priority for clinical pharmacy service in hospitalized internal medicine patients.

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“…The majority of hospitalised patients have drug-related problems (DRPs) [1][2][3][4][5][6][7][8][9][10][11] which are events or circumstances involving drug therapy that actually or potentially can interfere with the desired health outcomes [12]. The total cost of drug-related morbidity and mortality exceeds the cost of the medications themselves [3].…”

Section: Introductionmentioning

confidence: 99%

Clinical pharmacist service in the acute ward

Nielsen

Andersen

Rasmussen³

et al. 2013

Int J Clin Pharm

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Background The majority of hospitalised patients have drug-related problems. Clinical pharmacist services including medication history, medication reconciliation and medication review may reduce the number of drug-related problems. Acute and emergency hospital services have changed considerably during the past decade in Denmark, and the new fast-paced workflows pose new challenges for the provision of clinical pharmacist service. Objective To describe and evaluate a method for a clinical pharmacist service that is relevant and fit the workflow of the medical care in the acute ward. Setting Acute wards at three Danish hospitals. Methods The clinical pharmacist intervention comprised medication history, medication reconciliation, medication review, medical record entries and entry of prescription templates into the electronic medication module. Drug-related problems were categorised using The PCNE Classification V6.2. Inter-rater agreement analysis was used to validate the tool. Acceptance rates were measured as the physicians' approval of prescription templates and according to outcome in the PCNE classification. Main outcome measure Acceptance rate of the clinical pharmacists' interventions through the described method and inter-rater agreement using the PCNE classification for drug-related problems. Results During 17 months, 188 patients were included in this study (average age 72 years and 55 % women). The clinical pharmacists found drug-related problems in 85 % of the patients. In the 1,724 prescriptions, 538 drug-related problems were identified. The overall acceptance rate by the physicians for the proposed interventions was 76 % (95 % CI 74-78 %). There was a substantial inter-rater agreement when using the PCNE classification system. Conclusion The methods for a clinical pharmacist service in the acute ward in this study have been demonstrated to be relevant and timely. The method received a high acceptance rate, regardless of no need for oral communication, and a substantial inter-rater agreement when classifying the drug-related problems.

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Comparison of Drug-Related Problems in Different Patient Groups

Cited by 36 publications

References 23 publications

Characteristics of drug-related problems discussed by hospital pharmacists in multidisciplinary teams

Characteristics of drug-related problems discussed by hospital pharmacists in multidisciplinary teams

Comprehensive assessment of treatment related problems in hospitalized medicine patients in Jordan

Clinical pharmacist service in the acute ward

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