Comparison of Dose–Response Curves with Subcutaneous and Intravenous Histamine

Desai, H G; Zaveri, M. P.; Antia, F. P.

doi:10.1016/s0016-5085(19)33677-7

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…Details of the procedure are given in a previous study (Desai, Zaveri & Antia, 1970a). Pepsin estimation was performed in each half-hour sample by the method of Hunt (Hunt, 1948) using plasma as substrate; the blue colour with Folin and Ciocalteu reagent was measured on a colorimeter.…”

Section: Methodsmentioning

confidence: 99%

Minimal dose of a stimulus for maximal pepsin secretion

Desai

Zaveri

Antia

1973

Postgraduate Medical Journal

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Section: Methodsmentioning

confidence: 99%

Minimal dose of a stimulus for maximal pepsin secretion

Desai

Zaveri

Antia

1973

Postgraduate Medical Journal

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“…SHT were performed as described in a previous study (Desai, Zaveri & Antia, 1970). Maximal acid output (MAO) (0-60 min) was calculated by the method of Card & Marks (1960).…”

Section: Methodsmentioning

confidence: 99%

Minimal dose of histamine for maximal acid secretion in control subjects and patients with duodenal ulcerPart of the work was supported by a grant from TNMC and BYL Nair Charitable Hospital Research Society.

Desai

Zaveri

Antia

1972

Postgraduate Medical Journal

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Summary Dose-response curves were obtained from forty adult male control subjects and forty patients with duodenal ulcer by administering 1-6, 2-0, 2-4, 2-8, 3-2-mg doses of histamine acid phosphate (HAP) subcutaneously.The results showed that the minimal dose of HAP for MAO for patients with duodenal ulcer was significantly greater than that required for control subjects.A significant positive correlation between the minimal dose of HAP, independent of body weight, for MAO and the maximal acid secretory capacity of an individual was observed both in control subjects and patients with duodenal ulcer. THE smallest dose of histamine acid phosphate (HAP) for stimulating 'maximal' acid secretion was shown to be 0 04 mg/kg body weight on the subcutaneous histamine test (SHT) (Kay, 1953). Kay performed dose-response curves on SHT in five control subjects and five patients with duodenal ulcer only, and hence it was not determined whether subjects of these two groups with different parietal cell mass (PCM) (Cox, 1952) require the same or different doses for stimulating 'maximal' acid secretion.The object of this study was to perform doseresponse curves on SHT in a large number of control subjects and patients with duodenal ulcer with a view to determining the minimal doses for maximal acid secretion in each group.Material and methods Control subjects and patients SHT were performed in forty healthy adult male subjects (average age and weight 28 3 years and 47T6 kg respectively) and forty male patients (average age and weight 36-4 years and 47T0 kg respectively) with radiologically confirmed duodenal ulcer. MethodSHT were performed as described in a previous study (Desai, Zaveri & Antia, 1970). Maximal acid output (MAO) (0-60 min) was calculated by the method of Card & Marks (1960). Thirty-nine control subjects and thirty-six patients with duodenal ulcer received doses of 1-6, 2-0, 2-4, 2 8, 3-2 mg HAP subcutaneously and one control subject and four patients with duodenal ulcer, included from a previous study, (Desai, Borkar & Jeejeebhoy, 1967), received 40, 50, 60 kug/kg body weight doses of HAP. Six control subjects (with the minimal dose of HAP of 1-6 mg for MAO) also received 1-2 mg dose of HAP. Results Minimal dose of HAP (independent of, or in relation to body weight) for MAO Control subjects. The mean and standard deviation (SD) of the minimal doses of HAP for MAO, independent of or in relation to body weight, were 2 4±0-51 mg or 51P38+110 ,ug/kg body weight respectively on SHT.Patients with duodenal ulcer. The mean and SD of the minimal doses of HAP for MAO, independent of, or in relation to body weight, were 2-68 ±036 mg or 57-5 ±11 06 Vg/kg body weight respectively on SHT.The average minimal values of subcutaneous HAP for MAO in control subjects (2-4 mg or 51 38 kg/kg body weight) and patients with duodenal ulcer (2-68 mg or 57 5 rig/kg body weight) showed significant differences (P <0 01 and P <0 05 respectively). Maximal acid output and minimal dose of HAP for MAO Control subjects. A significant positive co...

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“…Dose-response curves to 2-0, 2-4, 2-8, and 3-2 mg of histamine acid phosphate subcutaneously; to 2-0, 2-4, and 2-8 mg/hr of histamine acid phospate intravenously (Desai, Zaveri and Antia 1970a); to 75, 100, and 125 mg of ametazole hydrocloride (Histalog) subcutaneously (Desai, Zaveri, and Antia, 1970b); and to 250, 300, and 350 ,tg of pentagastrin subcutaneously (Desai, Zaveri, and Antia, 1971) were obtained on different days, as described in previous studies. The dose-response curves for any one stimulus were completed within three weeks, but different stimuli were administered at various times according to the availability of the stimu!us or the convenience of the patient.…”

Section: Methodsmentioning

confidence: 99%