Spontaneous and Persisting Decrease in Maximal Acid Output

Community acquired acute Helicobacter pylori gastritis

“…Although there are a number of publications, very little is known about the acute phase of H. pylori gastritis. 5–26 This study shows that the prepared mind can prospectively identify some cases. Nevertheless, the spectrum of the initial presentation remains unknown.…”

Spontaneous Hypochlorhydria in Man: Possible Causes and Consequences

“…It is apparent that the subjects reported were either healthy individuals identified during the course of gastric secretory studies [4][5][6][7] or patients with Zollinger-Ellison syn drome who were under close medical super vision [8][9][10]. This suggests that the true inci dence of spontaneous hypochlorhydria may be much greater, and that these have been chance observations in selected individuals.…”

“…Another subject who had a duodenal ulcer developed a similar reduction in gastric acid output, but did not have biopsy performed. Desai et al [7] performed repeated gastric secretory stud ies on 7 patients with duodenal ulceration and 3 healthy controls. Initially, all had gas tric acid outputs within the accepted normal range.…”

“…This suggests that the true inci dence of spontaneous hypochlorhydria may be much greater, and that these have been chance observations in selected individuals. The occasional clustering of cases [5][6][7] sug gests the possibility of a transmissible agent being involved in the pathogenesis of the condition. Histological changes of gastritis were frequently recorded [5-8.…”

“…Doctors who have performed repeated tests of gastric se cretion on themselves have found prolonged periods of basal anacidity [2,3] when there had previously been a quantifiable basal acid output. There have been a number of reports of the development of achlorhydria in pre viously healthy individuals [4][5][6][7] and in pa tients with Zollinger-Ellison syndrome [8][9][10].…”