Comparison of Dose-Related Ocular Side Effects during Systemic Isotretinoin Administration

Abstract

During systemic isotretinoin treatment, eye dryness was related to the dose used, at least during the period of treatment. Conversely, the rate of conjunctival S aureus colonization was unrelated to the dose of isotretinoin.

Side effects of retinoid therapy on the quality of vision

“…Cumurcu et al (19) compared how the high-dose and low-dose isotretinoin treatments aff ect the vision. A group of 26 patients were treated with the high dose (> 0.5 mg kg -1 daily) of the drug and 25 patients with the low dose (< 0.5 mg kg -1 daily).…”

The Changes in Tear Film Parameters and Impression Cytology in Heavily Drinking Men

“…All values of 10 seconds or less were considered abnormal. 10 Impression cytology samples were obtained with nitrocellulose acetate filter papers (Whatman; GE Healthcare UK Limited, Buckinghamshire, United Kingdom) pressed onto the superior temporal bulbar conjunctiva adjacent to the corneal limbus after application of topical anaesthesia. 11 Samples were kept in 95% ethanol at 4°C, stained with periodic acid-Schiff, and graded by a blinded operator according to the procedure by Nelson as grade 0, normal cytology; grade 1, early squamous metaplasia; and grades 2 and 3, increasing severity of metaplasia (Figs.…”

Managing nonteratogenic adverse reactions to isotretinoin treatment for acne vulgaris

“…2 Cumurcu and colleagues further characterized the ophthalmic sequelae of isotretinoin and found that although patients on both low-and high-dose regimens reported photophobia, burning eyes, and ocular foreign body sensations, those in the high-dose group were more likely to exhibit these symptoms and were more bothered by them. 10 Patients in both groups reported that the adverse reactions resolved within 1 month of stopping isotretinoin treatment. Due to isotretinoin's drying effect, other patient-reported symptoms in these studies include pruritus, desquamation, epistaxis, dry nares, dry mucous membranes, dyspareunia, and abnormal menses.…”