Comparison of Disintegrant and Binder Activity of Three Corn Starch Products

Kottke, M. K.; Chueh, H.-R.; Rhodes, C. T.

doi:10.3109/03639049309073894

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…The concentration of starch used as disintegrant is also a very crucial factor. If it is below the optimum concentration then there are insufficient channels for capillary action and if it is above optimum concentration then it will be difficult to compress the tablet (Kottke et al, 1992). The ranking for DT and dissolution times for the formulations containing the starch disintegrants was corn>whi-te>water yam starches.…”

Section: Resultsmentioning

confidence: 97%

Effect of the mode of incorporation on the disintegrant properties of acid modified water and white yam starches

Odeku¹,

Akinwande²

2012

Saudi Pharmaceutical Journal

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Acid modified starches obtained from two species of yam tubers namely white yam - Dioscorea rotundata L. and water yam - D. alata L. DIAL2 have been investigated as intra- and extra-granular disintegrants in paracetamol tablet formulations. The native starches were modified by acid hydrolysis and employed as disintegrant at concentrations of 5 and 10% w/w and their disintegrant properties compared with those of corn starch BP. The tensile strength and drug release properties of the tablets, assessed using the disintegration and dissolution (t 50 and t 80 - time required for 50% and 80% of paracetamol to be released) times, were evaluated. The results showed that the tensile strength and the disintegration and dissolution times of the tablets decreased with increase in the concentration of the starch disintegrants. The acid modified yam starches showed better disintegrant efficiency than corn starch in the tablet formulations. Acid modification appeared to improve the disintegrant efficiency of the yam starches. Furthermore, tablets containing starches incorporated extragranularly showed faster disintegration but lower tensile strength than those containing starches incorporated intragranularly. This emphasizes the importance of the mode of incorporation of starch disintegrant.

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Section: Resultsmentioning

confidence: 97%

Effect of the mode of incorporation on the disintegrant properties of acid modified water and white yam starches

Odeku¹,

Akinwande²

2012

Saudi Pharmaceutical Journal

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“…Starchbased tablets (Kottke et al, 1992), capsules (Vilivalam et al, 2000), film coatings Milojevic et al, 1996), microspheres (Mundargi et al, 2008), subcutaneous implants (Désévaux et al, 2002) have all been exploited/utilized. Starch is one of the most widely used excipients in pharmaceutical formulations where it can be used both as a disintegrant and as a binder depending on the specific attributes necessary for the formulation (Cunningham, 1999).…”

Section: Introductionmentioning

confidence: 99%

A novel multifunctional pharmaceutical excipient: Modification of the permeability of starch by processing with magnesium silicate

Rashid

Al-Remawi

Leharne

et al. 2011

International Journal of Pharmaceutics

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“…Starch is a versatile excipient with many applications in oral solid dosage forms as a diluent, binder, and disintegrant. Starch acts as a disintegrant at a concentration of 3-25% (w/w), with an optimum concentration of 15% (w/w) [58][59][60][61]. However, before using starch, a prior granulation step is required to avoid problems associated with low flowability and compressibility that can cause powder segregation.…”

Section: Starch and Modified Starchmentioning

confidence: 99%

Insights Into Formulation Technologies and Novel Strategies for the Design of Orally Disintegrating Dosage Forms: A Comprehensive Industrial Review

Agiba¹,

Eldin²

2019

Int J Pharm Pharm Sci

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Among the various routes of administration, the oral route remains the most convenient and commonly employed route for drug delivery. The oral conventional drug delivery systems have some drawbacks, such as possibility of gastrointestinal destruction of labile molecules, low absorption of macromolecules, slow onset of action, and unavoidable fluctuation in the concentration of drugs which can either lead to under-or over medication with concomitant adverse effects, especially for drugs with small therapeutic index. Therefore, it became essential to design novel oral drug delivery systems to achieve quick dissolution, absorption, rapid onset of action and reduction of drug dose. Among those novel drug delivery systems are oral disintegrating tablets (ODTs). The purpose of this review article is to report the recent advances in ODT systems with emphasis on their preparations, characterizations and applications. Also, it highlights future prospects and possible challenges in the development of an ideal ODT system.

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Comparison of Disintegrant and Binder Activity of Three Corn Starch Products

Cited by 5 publications

References 8 publications

Effect of the mode of incorporation on the disintegrant properties of acid modified water and white yam starches

Effect of the mode of incorporation on the disintegrant properties of acid modified water and white yam starches

A novel multifunctional pharmaceutical excipient: Modification of the permeability of starch by processing with magnesium silicate

Insights Into Formulation Technologies and Novel Strategies for the Design of Orally Disintegrating Dosage Forms: A Comprehensive Industrial Review

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