A novel multifunctional pharmaceutical excipient: Modification of the permeability of starch by processing with magnesium silicate

Rashid, Iyad; Al-Remawi, Mayyas; Leharne, Stephen A.; Chowdhry, Babur Z.; Badwan, Adnan A.

doi:10.1016/j.ijpharm.2011.03.011

Cited by 23 publications

(22 citation statements)

References 25 publications

(24 reference statements)

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“…The swelling powers tended to decrease as the SS concentration increased. This finding was in agreement with a previous study by Rashid et al, in which starch coprecipitated with silicate exhibited low swelling capacity due to the restructuring of the starch pores when the concentration of magnesium silicate was increased . In this case, the changes in the solubility and swelling properties of the CXOs were more dependent on the coprocessing than on the ratio of etherification to cross‐linking reaction times.…”

Section: Resultssupporting

confidence: 93%

“…Increasing the amount of SS altered the arrangement and porosity of CXO by inhibiting bonding between starch particles . As a result, the enhanced porosity and interparticle space in the coprocessed starch increased the penetration of water into the starch particles . The solubility of SS in water also created an alkaline environment that facilitated gelatinization of starch, leading to higher solubility at higher SS concentrations .…”

Section: Resultsmentioning

confidence: 99%

“…The FSC values increased and reached their maximum with CXO prepared with 10% SS due to the attraction between water and the polymer due to SS . At higher concentrations (15–25%), self‐aggregation of the SS blocked the penetration of water through the pores, decreasing the free swelling capacity …”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Development of a Direct Compression Excipient from Epichlorohydrin-Crosslinked Carboxymethyl Rice Starch with Sodium Silicate Using a Coprocessing Technique

Trisopon

Kittipongpatana

2019

Starch - Stärke

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A new, free‐flowing tablet disintegrant based on a coprocessed, cross‐linked carboxymethyl rice starch (CXO) is developed using a combination of chemical and physical modifications. Cross‐linked carboxymethyl starches are synthesized from an etherification between native rice starch and monochloroacetic acid and a cross‐linking reaction with epichlorohydrin with various ratios of the etherification reaction time to the cross‐linking reaction time (1:1, 1:0.67, and 1:0.33). The modified starches are then coprecipitated with 0–25% sodium silicate solution in methanolic solvent to obtain the CXOs. The physicochemical properties of the CXOs are characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, X‐ray diffractometry, and differential scanning calorimetry. The solubility, swellability, moisture sorption capacity, and flowability parameters are also investigated and compared with those of native starch. A 10% sodium silicate solution is found to be best suited for coprocessing, yielding a modified starch (CXO‐12) with excellent flowability and compressibility. The lubricant sensitivity ratio of CXO (0.13) is 4–6 times lower than those of sodium starch glycolate (SSG) and croscarmellose sodium (CCS), and its dilution potential (11.2% w/w) is the best among the three excipients. The disintegration times of the model drug tablets containing CXO (16.83 ± 3.19 s) are not significantly different from those containing SSG (14.00 ± 2.45 s) or CCS (14.00 ± 2.83 s). A dissolution study showed that the drug release is greater than 80% after 15 min in the medium. These results suggest that CXO could be applied as a free‐flowing super disintegrant for direct compression processes.

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Development of a Direct Compression Excipient from Epichlorohydrin-Crosslinked Carboxymethyl Rice Starch with Sodium Silicate Using a Coprocessing Technique

Trisopon

Kittipongpatana

2019

Starch - Stärke

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“…Thus, starch derivatives have been used in formulations of tablets, microparticles and coating films in order to reach desired drug release rates (López, García, & Zaritzky, 2008;Marinich, Ferrero, & Jiménez-Castellanos, 2012;Rashid, Al-Remawy, Leharne, Chowdhry, & Badwan, 2011;Teacȃ, Bodîrlȃu, & Spiridon, 2013;Tuovinen, Peltonen, et al, 2004;Tuovinen, Ruhanena, et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Films from resistant starch-pectin dispersions intended for colonic drug delivery

Meneguin

Cury

Evangelista

2014

Carbohydrate Polymers

104

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Free films were obtained by the solvent casting method from retrograded starch-pectin dispersions at different polymer proportions and concentrations with and without plasticizer. Film forming dispersions were characterized according to their hardness, birefringence and rheological properties. The polymer dispersions showed a predominantly viscous behavior (G″>G') and the absence of plasticizers lead to building of stronger structures, while the occurrence of Maltese crosses in the retrograded dispersions indicates the occurrence of a crystalline organization. Analyses of the films included mechanical properties, thickness, superficial and cross sectional morphology, water vapor permeability, liquid uptake ability, X-ray diffractometry, in vitro dissolution and enzymatic digestion. The high resistant starch content (65.8-96.8%) assured the resistance of materials against enzymatic digestion by pancreatin. Changes in the X-ray diffraction patterns indicated a more organized and crystalline structure of free films in relation to isolated polymers. Increasing of pectin proportion and pH values favored the dissolution and liquid uptake of films. Films prepared with lower polymer concentration presented better barrier function (WVP and mechanical properties).

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“…Several compounds have been reported for use as tablet disintegrants including starch, cellulose, povidone and their derivatives [3]. Starch is a natural polymer which is widely employed in pharmaceutical formulations before or after physical and/or chemical modifications with the aim of improving its ability to swell in water, and to confer higher hardness and lower friability to the tablets [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Alcohol-Alkaline-Treated Rice Starch as a Tablet Disintegrant

Boonwatcharapan¹,

Srisuk²,

Palladino³

et al. 2016

Trop. J. Pharm Res

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A novel multifunctional pharmaceutical excipient: Modification of the permeability of starch by processing with magnesium silicate

Cited by 23 publications

References 25 publications

Development of a Direct Compression Excipient from Epichlorohydrin-Crosslinked Carboxymethyl Rice Starch with Sodium Silicate Using a Coprocessing Technique

Development of a Direct Compression Excipient from Epichlorohydrin-Crosslinked Carboxymethyl Rice Starch with Sodium Silicate Using a Coprocessing Technique

Films from resistant starch-pectin dispersions intended for colonic drug delivery

Preparation and Evaluation of Alcohol-Alkaline-Treated Rice Starch as a Tablet Disintegrant

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