Comparison of Disintegrant and Binder Activity of Three Corn Starch Products

Kottke, M. K.; Chueh, H.-R.; Rhodes, C. T.

doi:10.3109/03639049209038758

Cited by 27 publications

(18 citation statements)

References 10 publications

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“…The lowest Carr's index (better owability) was for Spherolac 100 reecting its more efficient particle packing when in a conditioned and low stress state, due to having larger particle size and lower cohesivity. 33 This however was not the case here as these disintegrants could act as binders 34 and stick ibuprofen particles together to make ibuprofen-disintegrant granules. The shear properties of 8 different powders, which varied in particle size and shape using an annular shear cell was also reported.…”

Section: Density and Owabilitymentioning

confidence: 93%

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Crystal engineering of ibuprofen using starch derivatives in crystallization medium to produce promising ibuprofen with improved pharmaceutical performance

et al. 2015

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Ibuprofen exhibits poor flow, poor compaction and dissolution behaviour, and it is prone to capping after ejection from the die. Therefore, the aim of the present research was to engineer ibuprofen crystals in the presence of two disintegrants (starch and sodium starch glycolate) in order to improve its flow, compactibility and dissolution behaviour simultaneously. To this end ibuprofen and different concentrations of disintegrant (0.25 to 10% w/w in case of starch and 0.25 to 7% w/w in case of sodium starch glycolate) were dissolved in ethanol and water respectively. The ibuprofen solution was then added to the aqueous solutions containing the different concentrations of disintegrant. Ibuprofen precipitated within 10 min and the crystals were separated and dried for further studies. The obtained crystals were characterized in terms of flow, density, tablet hardness, dissolution behaviour and solid state. The results showed most of engineered ibuprofen to have better flow with a high compactibility. The results also showed that an increase in the concentration of starch in the crystallization medium resulted in a reduction in the hardness of ibuprofen tablets, but this was not the case for ibuprofen samples engineered in the presence of sodium starch glycolate. It is interesting to note that although engineered ibuprofen showed superior dissolution as compared to untreated ibuprofen, the highest concentration of starch (10%) or sodium starch glycolate (7%) slowed down the release remarkably due to an increase in the viscosity of the dissolution medium around drug particles. Solid state analysis (FT-IR, XRPD and DSC) ruled out the presence of different polymorphic forms and also any interaction between these disintegrants and ibuprofen. In conclusion, the engineering of ibuprofen in the presence of disintegrant showed how properties such as flow, compaction and dissolution behaviour can be simultaneously manipulated to suit a desired application

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Section: Density and Owabilitymentioning

confidence: 93%

“…12,13 Sodium starch glycolate is mainly used as a modern super disintegrant in oral dosage forms. 12,13 Sodium starch glycolate is mainly used as a modern super disintegrant in oral dosage forms.…”

Section: Introductionmentioning

confidence: 99%

Crystal engineering of ibuprofen using starch derivatives in crystallization medium to produce promising ibuprofen with improved pharmaceutical performance

et al. 2015

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“…Starch is a versatile excipient used primarily in pharmaceutical formulations as thickening agent, emulsifier, binder, diluent, disintegrant, film former and bioadhesive . Starch is used as a tablet disintegrant in the concentrations of 3–25% and other site‐specific delivery systems . Modified starches have achieved a wide range of functions from binding or disintegrating and imbibing or inhibiting moisture in tablet formulations .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterisation of starch tartrate and its application as novel disintegrant in telmisartan tablets

et al. 2013

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The aim of the present study was to synthesize potato starch (PS) derivatives of tartaric acid (TA) under semi‐dry conditions and to evaluate the physicochemical properties as per official compendia requirements. Starch tartrate (ST) was synthesized by reacting PS (St–OH) and TA in semi‐dry condition using sodium hypophosphite (SHP) as a catalyst. Further we have applied its use as disintegrant in directly compressed telmisartan tablets. The microscopic, spectroscopic (FTIR), thermal (DSC) and crystallographic (XRD) studies confirmed the formation of ST. No gelling was observed at 100°C but it was converted to a clear solution with a swelling index of 1.666 times. ST was found to have suitable compression properties required for directly compressible tablets. The tablets formulated employing ST (5–15% w/w) as disintegrant gave rapid disintegration and dissolution rates compared to those prepared using commercial superdisintegrants (sodium starch glycolate and crosscarmellose sodium). The optimized formulation showed disintegration time of 31 ± 3 s which is found superior to that of others. It is concluded that the synthesized ST could be employed as a promising disintegrant in dispersible tablet formulations.

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“…Binders are pharmaceutical excipient that are commonly employed in tablet formulation to impact cohesion on the powder mix and hence improves on the flow properties on the granules (Kottke et al, 1992;DiSanto, 1995;Prescott and Barnum, 2000). Binders act by causing aggregation of powders thereby forming granules through the process of granulation.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the binder effects of the gum mucilages of Cissus populnea and Acassia senegal on the mechanical properties of paracetamol tablets

Eichie¹,

F²,

Amalime³

et al. 2007

Afr. J. Biotechnol.

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A comparative study has been carried out to investigate the binder effects of the gums of Cissus populnea and Accasia senegal on the mechanical properties of paracetamol tablets. Tablet mechanical properties evaluated include the packing fraction (P f), the tensile strength (T) and the brittle fracture tendency (BFI). Varying concentrations of the gum mucilage ranging from 1-15% (w/v) was prepared and their relative viscosities determined. Each concentration was used to wet massed paracetamol powder to form granules. Tablets of paracetamol (500 ± 6.5 mg) were compressed at a constant compression load (7 arbitruary units on the scale). The tablets were equilibrated for 24 h before evaluation. At all binder concentrations A. senegal gum produced harder and more consolidated tablets than C. populnea as reflected by the higher T and P f values respectively. For instance, the T and P f values of the tablets at binder concentration of 10% (w/v) were 0.69 MNm-2 and 0.47 (A. senegal) and 0.57 MNm-2 and 0.23 (C. populnea), respectively. On the contrary, an increase in binder concentration generally resulted in a decrease in BFI values and this decrease was more marked with C. populnea. The study showed that A. senegal mucilage displayed better tableting characteristics and higher tendency for ameliorating capping tendency. Both mucilages have the potentials for substitution as binder for the more expensive starches in tablet formulation.

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Comparison of Disintegrant and Binder Activity of Three Corn Starch Products

Cited by 27 publications

References 10 publications

Crystal engineering of ibuprofen using starch derivatives in crystallization medium to produce promising ibuprofen with improved pharmaceutical performance

Crystal engineering of ibuprofen using starch derivatives in crystallization medium to produce promising ibuprofen with improved pharmaceutical performance

Synthesis and characterisation of starch tartrate and its application as novel disintegrant in telmisartan tablets

Evaluation of the binder effects of the gum mucilages of Cissus populnea and Acassia senegal on the mechanical properties of paracetamol tablets

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