Comparison of Diphosphonate Effects on Enamel in vitro and in vivo

Wöltgens, J.H.M.; Koulourides, T.

doi:10.1159/000260688

Cited by 8 publications

(6 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Contradictory findings concerning bisphosphonates from in vivo and in vitro studies have been reported. The inhibited reminerali zation of enamel has been observed in vitro [Miihlemann and Aeschbacher, 1970;ten Cate et al, 1981;Wôltgens and Koulourides, 1983]. No such pheno menon has been demonstrated when bisphosphonate effect on enamel in vivo was studied [Wôltgens and Koulourides, 1983].…”

Section: Introductionmentioning

confidence: 99%

“…The inhibited reminerali zation of enamel has been observed in vitro [Miihlemann and Aeschbacher, 1970;ten Cate et al, 1981;Wôltgens and Koulourides, 1983]. No such pheno menon has been demonstrated when bisphosphonate effect on enamel in vivo was studied [Wôltgens and Koulourides, 1983]. The bisphosphonate disodium Total Drop outs 1 11 III IV V Randomization 231 232 237 231 230 1,161 Baseline 229 229 234 229 225 1,146 15 1 year 214 221 226 217 212 1,090 56 2 year 206 216 220 211 210 1,063 27 3 year 203 209 211 209 203 1,035 28 1-hydroxyethylidene-1.1 -bisphosphonate (HEBP) re duced mineral loss in enamel during the in situ Intra oral Cariogenicity Test, and the effect was additive when fluoride and bisphosphonate were applied sim ultaneously [Wôltgens et al, 1984;van Croonenburg et al, 1986].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Caries-Preventive Effect of Fluoride Dentifrices with and without Anticalculus Agents: A 3-Year Controlled Clinical Trial

Koch¹,

Bergmann-Arnadottir

Bjarnason

et al. 1990

Caries Res

View full text Add to dashboard Cite

A 3-year, double-blind, randomized caries trial was conducted to evaluate the relative anticaries efficacy of four sodium fluoride dentifrices containing 250 ppm fluoride, 1,000 ppm fluoride in combination with 1% disodium 1-hydroxyethylidene-1.1-bisphosphonate (HEBP), and 1,000 ppm fluoride in combination with 1% disodium azacycloheptylidene-2.2-bisphosphonate (AHBP). As a positive control, a monofluorophosphate dentifrice (1,000 ppm fluoride) was used. At outset 1,161 Icelandic children, 11 and 12 years of age, were randomly assigned to one of the five treatment groups and 1,035 subjects completed the trial. After 3 years of unsupervised brushing, the dentifrice containing 250 ppm fluoride was significantly less effective in controlling the caries increment. The combination of sodium fluoride and AHBP was significantly more effective than the positive control.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Caries-Preventive Effect of Fluoride Dentifrices with and without Anticalculus Agents: A 3-Year Controlled Clinical Trial

Koch¹,

Bergmann-Arnadottir

Bjarnason

et al. 1990

Caries Res

View full text Add to dashboard Cite

show abstract

“…The strong inhibitory effects of polyphosphonates as well as polyphosphates on crystal dissolution could, there fore, provide a caries benefit by increasing resistance to acid damage [Anbar et al, 1974b;Bartels et al, 1979]. Indeed, in vivo studies of ethane hydroxydiphosphonate showed cariostatic benefits due to in creased enamel resistance to acid exposure [Woltgens and Koulourides, 1983], and animal caries experi ments showed positive anticaries effects of this com pound [Regolati and Muhlemann, 1979],…”

mentioning

confidence: 99%

Effect of an Anticalculus Dentifrice on Lesion Progression under pH Cycling Conditions in vitro

et al. 1988

View full text Add to dashboard Cite

The aim of the present study was to examine a sodium fluoride anticalculus dentifrice product containing soluble pyrophosphate for its ability to promote remineralization and/or inhibit demineralization of dental enamel in a pH cycling model in vitro. Enamel crowns with windows were subjected to 14 days of alternating demineralization and remineralization periods at 37 °C. Teeth were immersed 5 min daily in one of the test dentifrice systems (1:3 slurry in deionized water) between the demineralization and remineralization cycles. Test dentifrices included (1) sodium fluoride (NaF; 1,100 ppm F)/silica abrasive (Crest) and (2) NaF (1,100 ppm F) with 3.3% soluble pyrophosphate/silica abrasive (Crest Tartar Control). Controls included a placebo dentifrice (silica abrasive) with no added fluoride and a group which received no treatment at all, i.e., demineralization/remineralization only. Overall, both of the NaF dentifrices were very effective in limiting in vitro caries progression and were not significantly different from each other. Inclusion of pyrophosphate in the NaF dentifrice did not affect the net outcome of the cycling demineralization/remineralization processes which is in agreement with recent clinical and in situ studies of these products.

show abstract

“…Immersion of artificial lesions in 0.05% EHDP-O.l % F solutions for ten minutes four times daily followed by placing them in the mouth for one week produced the same amount of rehardening as did the same solution without EHDP (Woltgens and Koulourides, 1983). The use of three different formulations of F dentifrices containing 3.3% pyrophosphate for two weeks provided 22.4%, 28.8%, and 35.2% remineralization of artificial lesions.…”

Section: Frequently Used and Low-concentration Fluoride Preparationsmentioning

confidence: 86%

“…Although diphosphonates and pyrophosphates may interfere with remineralization and fluoride uptake in vitro (Woltgens and Koulourides, 1983;Mellberg et al, unreported data), the evidence shows that they do not interfere in situ. Immersion of artificial lesions in 0.05% EHDP-O.l % F solutions for ten minutes four times daily followed by placing them in the mouth for one week produced the same amount of rehardening as did the same solution without EHDP (Woltgens and Koulourides, 1983).…”

Section: Frequently Used and Low-concentration Fluoride Preparationsmentioning

confidence: 99%

Evaluation of Topical Fluoride Preparations

Mellberg

1990

J Dent Res

View full text Add to dashboard Cite

For practical reasons, evaluation of topical fluoride products must depend upon clinical and laboratory assessments. While not always a good predictor of clinical efficacy by itself, fluoride uptake is the most commonly used laboratory test. A consideration of the relationship between possible anticaries mechanisms of fluoride, different product types, and the meaning of various kinds of fluoride uptake data suggests that both the amount of fluoride taken up by early lesions and the amount of ambient fluoride present at a cariogenic site may play key roles in determining the efficacy of a product. While formulations applied annually or semi-annually probably depend on fluoride deposition, those used daily might not. There are no clear data supporting the superiority of one fluoride compound over another, even for infrequently used products, although there are significant differences among them in fluoride uptake by enamel. This suggests that fluoride uptake in vivo at a cariogenic site might actually be different from that suggested by in vitro data, or that larger differences are required for a clinical effect to be observable. Clinical data support the conclusion that a large increase in the fluoride concentration of a product will somewhat increase its anticaries effectiveness, although the increase will not be linearly related to concentration. There also are no obvious differences in clinical effectiveness caused by the addition of gelling agents to topical solutions. Fluoride varnishes are clinically effective but have not been shown to be superior to topical solutions or gels.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Comparison of Diphosphonate Effects on Enamel in vitro and in vivo

Cited by 8 publications

References 3 publications

Caries-Preventive Effect of Fluoride Dentifrices with and without Anticalculus Agents: A 3-Year Controlled Clinical Trial

Caries-Preventive Effect of Fluoride Dentifrices with and without Anticalculus Agents: A 3-Year Controlled Clinical Trial

Effect of an Anticalculus Dentifrice on Lesion Progression under pH Cycling Conditions in vitro

Evaluation of Topical Fluoride Preparations

Contact Info

Product

Resources

About